Effects of the IGF‐I/IGFBP‐3 complex on GH and ghrelin nocturnal concentrations in low birth weight children

Íñiguez, Germán; Salazar, Teresa; Román, Rossana; Ávila, Alejandra; Gunn, Ronald D.; Cassorla, Fernando

doi:10.1111/j.1365-2265.2006.02650.x

Cited by 15 publications

(14 citation statements)

References 37 publications

(59 reference statements)

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“…Serum IGFBP-3 and leptin concentrations were determined using a commercial immunoradiometric assay (Diagnostic System Laboratories, Webster, Tex., USA). The sensitivities of the assays are 0.1 mg/l and 0.1 ng/ml, respectively; the intra-assay CV is 1.1%, and the inter-assay CV is 1.8% for IGFBP-3, and the intra-assay CV is 4.6%, and the interassay CV, 6.2% for leptin [23,24] . IGF-II serum concentrations were determined using a commercial IGF-II IRMA system (Diagnostic System Laboratories).…”

Section: Methodsmentioning

confidence: 99%

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

et al. 2010

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Section: Methodsmentioning

confidence: 99%

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

et al. 2010

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“…As shown in table 2, serum IGF-I and IGFBP-3 levels were within normal ranges at baseline, and significantly increased 4 h after the administration of Iplex. As previously reported, however, the magnitude of the increase was greater for IGF-I than for IGFBP-3 [22]. The hematocrit did not change significantly after nocturnal blood sampling in any patient.…”

Section: Resultsmentioning

confidence: 48%

“…That study showed an increase in nocturnal ghrelin concentrations after the administration of Iplex, suggesting a positive feed-back effect of IGF-I and/or IGFBP-3 on ghrelin [22]. In the current study, we have determined the acute effects of IGF-I and/or IGFBP-3 on overnight leptin and insulin concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Nocturnal Leptin and Insulin Concentrations in Prepubertal Low Birth Weight Children after Administration of the IGF-I/IGFBP-3 Complex

Íñiguez¹,

Román²,

Ávila

et al. 2009

Horm Res Paediatr

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Background: There is limited information regarding the effects of IGF-I and/or IGFBP-3 on circulating leptin concentrations. Aim: To determine the effects of IGF-I on leptin and insulin concentrations, we examined leptin and insulin nocturnal profiles before and after the administration of the IGF-I/IGFBP-3 complex (Iplex™) to prepubertal, low birth weight children. Methods: We studied 20 prepubertal children (11 boys and 9 girls), born after a full-term pregnancy with a mean birth weight below 2.8 kg. They were studied at the mean age of 7.3 ± 0.5 years (range 4–11 years). Their mean height was –1.8 ± 0.3 SDS and their mean BMI was 0.1 ± 0.2 SDS at the time of the study. The children were studied on 2 separate occasions, the first under basal conditions, and the second time after s.c. administration of 1 mg/kg of Iplex™ at 21.00 h. Blood samples for determination of leptin and insulin were obtained every 60 min between 23.00 h and 07.00 h, while the children were sleeping. In each patient, we calculated the leptin and insulin mean area under the curve, both under basal conditions and after the administration of the IGF-I/IGFBP-3 complex. Results: Mean nocturnal leptin area under the curve exhibited a significant increase (2.7 ± 2.1 vs. 11.2 ± 2.6 ng/ml h, p < 0.05), whereas that for mean insulin showed a slight decrease, which did not reach statistical significance after administration of the IGF-I/IGFBP-3 complex. Conclusion: These findings indicate that administration of the IGF-I/IGFBP-3 complex increases circulating leptin concentrations in short prepubertal, small for gestational age children, suggesting that IGF-I and/or IGFBP-3 may stimulate leptin secretion by adipose tissue.

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“…This inhibitory effect of somatostatin on ghrelin may be considered as a negative feedback modulation as ghrelin increases the level of somatostatin in plasma. 94 Cortisol and fatty acids also exert a negative feedback on ghrelin secretion. The increase of ghrelin at and before midnight may be explained by low cortisol at that time.…”

Section: Leptin (Ghrelin-leptin Tango)mentioning

confidence: 99%

Ghrelin – Physiological Functions and Regulation

Abdalla

2015

European Endocrinology

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Ghrelin is an orexigenic peptide predominantly secreted from the stomach and stimulates appetite and growth hormone (GH) release.Studies have provided evidence that ghrelin exercises a wide range of functions, including regulation of food intake and energy metabolism, modulation of cardiovascular function, stimulation of osteoblast proliferation and bone formation and stimulation of neurogenesis and myogenesis. In the gastrointestinal system, ghrelin affects multiple functions, including secretion of gastric acid, gastric motility and pancreatic protein output. Most of these functions have been attributed to the actions of acylated ghrelin. The balance among its secretion rate, degradation rate and clearance rate determines the circulating level of ghrelin. This review explains what ghrelin is, its physiological functions and the factors that influence its level. KeywordsGhrelin, food intake, obesity, lipolysis, ghrelin receptors, regulation Disclosure: Mona Mohamed Ibrahim Abdalla has no conflicts of interest to declare. Acknowledgement:A note of appreciation to Research Management Centre of MAHSA University, Malaysia for funding publication of this article.

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Effects of the IGF‐I/IGFBP‐3 complex on GH and ghrelin nocturnal concentrations in low birth weight children

Cited by 15 publications

References 37 publications

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

Effects of Prenatal Ethanol Exposure on Postnatal Growth and the Insulin-Like Growth Factor Axis

Changes in Nocturnal Leptin and Insulin Concentrations in Prepubertal Low Birth Weight Children after Administration of the IGF-I/IGFBP-3 Complex

Ghrelin – Physiological Functions and Regulation

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