2006
DOI: 10.1111/j.1365-2265.2006.02650.x
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Effects of the IGF‐I/IGFBP‐3 complex on GH and ghrelin nocturnal concentrations in low birth weight children

Abstract: These findings indicate that the IGF-I/IGFBP-3 complex appears to have opposite effects on circulating GH and ghrelin concentrations in low birth weight children, suggesting that, in addition to its known negative feed-back effect on GH, IGF-I and/or IGFBP-3 may have a positive feed-back effect on ghrelin.

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Cited by 16 publications
(15 citation statements)
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“…Serum IGFBP-3 and leptin concentrations were determined using a commercial immunoradiometric assay (Diagnostic System Laboratories, Webster, Tex., USA). The sensitivities of the assays are 0.1 mg/l and 0.1 ng/ml, respectively; the intra-assay CV is 1.1%, and the inter-assay CV is 1.8% for IGFBP-3, and the intra-assay CV is 4.6%, and the interassay CV, 6.2% for leptin [23,24] . IGF-II serum concentrations were determined using a commercial IGF-II IRMA system (Diagnostic System Laboratories).…”
Section: Methodsmentioning
confidence: 99%
“…Serum IGFBP-3 and leptin concentrations were determined using a commercial immunoradiometric assay (Diagnostic System Laboratories, Webster, Tex., USA). The sensitivities of the assays are 0.1 mg/l and 0.1 ng/ml, respectively; the intra-assay CV is 1.1%, and the inter-assay CV is 1.8% for IGFBP-3, and the intra-assay CV is 4.6%, and the interassay CV, 6.2% for leptin [23,24] . IGF-II serum concentrations were determined using a commercial IGF-II IRMA system (Diagnostic System Laboratories).…”
Section: Methodsmentioning
confidence: 99%
“…As shown in table 2, serum IGF-I and IGFBP-3 levels were within normal ranges at baseline, and significantly increased 4 h after the administration of Iplex. As previously reported, however, the magnitude of the increase was greater for IGF-I than for IGFBP-3 [22]. The hematocrit did not change significantly after nocturnal blood sampling in any patient.…”
Section: Resultsmentioning
confidence: 48%
“…That study showed an increase in nocturnal ghrelin concentrations after the administration of Iplex, suggesting a positive feed-back effect of IGF-I and/or IGFBP-3 on ghrelin [22]. In the current study, we have determined the acute effects of IGF-I and/or IGFBP-3 on overnight leptin and insulin concentrations.…”
Section: Discussionmentioning
confidence: 99%
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“…This inhibitory effect of somatostatin on ghrelin may be considered as a negative feedback modulation as ghrelin increases the level of somatostatin in plasma. 94 Cortisol and fatty acids also exert a negative feedback on ghrelin secretion. The increase of ghrelin at and before midnight may be explained by low cortisol at that time.…”
Section: Leptin (Ghrelin-leptin Tango)mentioning
confidence: 99%