Effects of the herbal medicine inchinko-to on liver function in postoperative patients with biliary atresia—a pilot study

Iinuma, Yasushi; Kubota, Masayuki; Yagi, Minoru; Kanada, Satoshi; Yamazaki, Satoru; Kinoshita, Yoshiaki

doi:10.1016/s0022-3468(03)00570-0

Cited by 24 publications

(22 citation statements)

References 16 publications

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“…Iinuma, et al reported that Inchinkoto might have a protective and antifibrotic effect for the liver of children with biliary atresia [6] [7]. Though the precise mechanisms of its action on the liver diseases remain unknown, it can be speculated as following: 1) inhibition of hepatocyte apoptosis induced by transforming growth factor-β1 [10]; 2) inhibition of the production of inflammatory cytokines and inducible nitric oxide synthase [11] [12]; and 3) direct suppression of liver fibrosis [13].…”

Section: Discussionmentioning

confidence: 99%

“…Considering its reported efficacy on liver fibrosis in children with postoperative biliary atresia [6] [7], the Japanese herbal medicine, Inchinkoto (Tsumura & Co., Tokyo, Japan) was orally administered at the dose of 0.15 g/kg•per•day) since PD 100. In parallel with the commencement of Inchinkoto, both D-bil and HA gradually decreased to 18.3 mg/dL and 1280 ng/mL, respectively on PD 144 (Figure 1).…”

Section: Case Descriptionmentioning

confidence: 99%

“…Inchinkoto is a mixture of three medical herbs: Artemisia capillaries spica, Gardenia fructus and Rhei rhizome, and has long been used in Japan, mainly for liver disorders and jaundice [5] [6]. Several authors have claimed that Inchinkoto improves liver function and suppresses liver fibrosis in children with postoperative biliary atresia without serious side effects [6] [7].…”

Section: Introductionmentioning

confidence: 99%

“…Several authors have claimed that Inchinkoto improves liver function and suppresses liver fibrosis in children with postoperative biliary atresia without serious side effects [6] [7]. However, efficacy of How to cite this paper: Washio, R., Takahashi, M., Yamanouchi, S., Hirabayashi, M., Mine, K., Noda, Y., Kanda, E., Ohashi, A., Kawasaki …”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Inchinkoto for Liver Cirrhosis in an Infant with Down Syndrome Complicated by Transient Myeloproliferative Disorder

Washio¹,

Takahashi²,

Yamanouchi³

et al. 2017

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Several patients with Down syndrome complicated by transient myeloproliferative disorder may develop liver cirrhosis for which no effective therapeutic agent exists. We report the infant with Down syndrome complicated by transient myeloproliferative disorder and liver cirrhosis who was successfully treated by Inchinkoto, the Japanese herbal medicine. In the present case, Inchinkoto appeared to prevent both histological and serological aggravation of liver cirrhosis. To the best of our knowledge, this is the first report of preventive effect of Inchinkoto on liver cirrhosis, and it can be a choice of treatment for infants with Down syndrome complicated by liver cirrhosis.

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Section: Discussionmentioning

confidence: 99%

Section: Case Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of Inchinkoto for Liver Cirrhosis in an Infant with Down Syndrome Complicated by Transient Myeloproliferative Disorder

Washio¹,

Takahashi²,

Yamanouchi³

et al. 2017

OJPed

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“…Recently, ICKT has been reported to have a potent inhibitory effect on hepatocyte apoptosis, induced by transforming growth factor-beta 1 (TGF-beta1), and it inhibits the production of inflammatory cytokines in concanavalin A-induced hepatitis [4,5]. Furthermore, ICKT has been reported to directly suppress liver fibrosis in vivo [6,7]. Clinical reports in Japan also suggest that ICKT might be beneficial for the treatment of hepatobiliary diseases in adults [7].…”

Section: Introductionmentioning

confidence: 99%

The herbal medicine Inchinko-to reduces hepatic fibrosis in cholestatic rats

et al. 2011

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Calcification of the mesenteric veins suspected of idiopathic mesenteric phlebosclerosis associated with long‐term herbal medicine ‘inchinkoto’ prescribed for biliary atresia: A multicenter study

Hashizume,

Sugita,

Masui

et al. 2024

Traditional & Kampo Medicine

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AimInchinkoto (ICKT) is administered to patients with biliary atresia (BA) after surgery. Gardeniae fructus which is contained in ICKT is reported to be associated with idiopathic mesenteric phlebosclerosis (IMP). We investigated the influence of ICKT on calcification of the mesenteric veins suspected of IMP in BA patients.MethodsAll BA patients with native liver survival who received ICKT after Kasai portoenterostomy were reviewed. All patients underwent abdominal computed tomography (CT) during treatment. Calcification of the mesenteric veins on the most recent CT scan after the initiation of ICKT was assessed.ResultsTwenty patients (6 males and 14 females) were enrolled in this study. Of these patients, 17 (85.0%) and 10 (50%) patients had used ICKT for ≥5 years and >10 years, respectively. Calcification of the mesenteric veins was detected in one patient, who was a 14 year old girl. The total dosage of Gardeniae fructus was 21 800 g.ConclusionsThe incidence of calcification of the mesenteric veins in BA patients receiving ICKT was low. However, it is necessary to be aware that ICKT containing Gardeniae fructus is associated with the risk of developing calcification of the mesenteric veins suspected of IMP.

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Effects of the herbal medicine inchinko-to on liver function in postoperative patients with biliary atresia—a pilot study

Cited by 24 publications

References 16 publications

Efficacy of Inchinkoto for Liver Cirrhosis in an Infant with Down Syndrome Complicated by Transient Myeloproliferative Disorder

Efficacy of Inchinkoto for Liver Cirrhosis in an Infant with Down Syndrome Complicated by Transient Myeloproliferative Disorder

The herbal medicine Inchinko-to reduces hepatic fibrosis in cholestatic rats

Calcification of the mesenteric veins suspected of idiopathic mesenteric phlebosclerosis associated with long‐term herbal medicine ‘inchinkoto’ prescribed for biliary atresia: A multicenter study

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