Effects of the herb mixture, DTS20, on oxidative stress and plasma alcoholic metabolites after alcohol consumption in healthy young men

Abstract

BackgroundThis study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers.MethodsDTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water. Thirty minutes later, the volunteers ingested one bottle of Soju, which is a commercially available liquor (19% alcohol in 360 mL).ResultsVolunteers received the opposite treatment after a 1-week washout period. DTS20 is mainly composed of sugars (564.5 mg/g) and polyphenol (28.2 mg/g). Alcohol levels in the DTS20 group were significantly lower than the control group at 2 hours after drinking Soju (p < 0.05). Acetaldehyde levels in the DTS20 group tended to be lower than the control group at 2 hours after drinking Soju, but was not significantly different. The antioxidant activity level was also significantly different between the control and DTS20 group 2 hours after drinking Soju (p < 0.05). No differences in plasma alanine transaminase or aspartate transaminase levels were observed between plasma levels before drinking and 2 hours after drinking Soju in the control group.ConclusionIt was concluded that DTS20 reduced oxidative stress and hangover by mitigating plasma alcohol concentrations and elevating antioxidative activity in healthy male adults.

Influence of food commodities on hangover based on alcohol dehydrogenase and aldehyde dehydrogenase activities

“…Asparagus officinalis ( Kim et al., 2009 ) and red ginseng ( Lee et al., 2014b ) have been reported to have the ability to exert a positive effect on the activity of the hepatic enzymes due to their antioxidant activity. A herbal formulation, "DTS20" has been shown to prevent gastric mucous damage and also accelerate the metabolism of alcohol ( Hong, 2015 ). Hence, it has been widely considered that compounds having antioxidant property would have the ability to enhance the activity of ADH and ALDH.…”

“…by either enhancing the activity of ALDH and/or ADH and thereby assisting in aldehyde and alcohol clearance from the system, respectively. A herbal mixture “DTS 20” containing Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%) has also been studied and found to reduce the oxidative stress and plasma alcohol concentrations ( Hong, 2015 ).…”

Effect of Mixed Fruit and Vegetable Juice on Alcohol Hangovers in Healthy Adults

“…Alcohol hangover symptoms were relieved by increasing the activities of alcohol degrading enzymes ( 13 ). It was reported that elevation of the activities of alcohol metabolizing enzymes could be beneficial in eliminating of alcohol metabolites ( 13 , 15 , 25 ). Several natural products have been reported to reduce the levels of blood alcohol metabolites by increasing the activities of alcohol degrading enzymes, including Korean pear juice ( 13 ), red ginseng ( 15 ), and herbal mixture ( 25 ).…”

“…It was reported that elevation of the activities of alcohol metabolizing enzymes could be beneficial in eliminating of alcohol metabolites ( 13 , 15 , 25 ). Several natural products have been reported to reduce the levels of blood alcohol metabolites by increasing the activities of alcohol degrading enzymes, including Korean pear juice ( 13 ), red ginseng ( 15 ), and herbal mixture ( 25 ). Lee et al ( 13 ) demonstrated that Korean pear juice may improve alcohol detoxification by stimulating the activities of ADH and ALDH.…”

“…Lee et al ( 13 ) demonstrated that Korean pear juice may improve alcohol detoxification by stimulating the activities of ADH and ALDH. In another study, a herbal mixture extract of Viscum album L., Lycium chinense L., Inonotus obliques , and Acanthopanax senticosus H. alleviated alcohol hangover symptoms by reducing plasma alcohol levels in healthy adult males ( 25 ). In the present study, AGP juice increased ADH and ALDH activities by 32.0% and 27.4% in vitro , indicating that alcohol and acetaldehyde are degraded rapidly after alcohol consumption, which prevents accumulation of alcohol metabolites.…”