Effects of the Glucosinolate Sinigrin in Combination With a Noniodine Supplemented Diet on Serum Iodine and Thyroid Hormone Concentrations in Nonpregnant Mares

Lopez-Rodriguez, Maria Fernanda; Cymbaluk, Nadia F.; Epp, Tasha; Laarveld, B.; Recalde, Elena Carolina Serrano; Simko, Elemir; Card, Claire

doi:10.1016/j.jevs.2020.103110

Cited by 7 publications

(7 citation statements)

References 19 publications

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“…The circulating thyroxine (T4) and growth hormone (GH) can be considered as key indicators of metabolic activity, nutritional status, and livestock production (Todini et al, 2007;Oberbauer, 2015). It is well known that both T4 and GH have taken variable roles in regulating the balance of energy and protein metabolism, thermoregulation, and growth parameters in various tissues (Lopez-Rodriguez et al, 2020). Sheep breeding has great economic importance in the Middle East in such a way sheep industry has become the main source of income for breeders in these regions.…”

Section: Introductionmentioning

confidence: 99%

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Aljubouri

Al-Khafaji

Al-Shuhaib

2021

Basrah J. Agric. Sci.

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This study was conducted in the animal field of the Al-Kafeel Company from November 2019 till May 2020 to investigate the possible association between growth hormone (GH) and thyroxine (T4) with the growth traits in Awassi and Karakul sheep. The total number of animals which used in the study was 60 lambs, 28 (13 males and 15 females) from Karakul and 32 (18 males and 14 females) from Awassi. Blood samples were collected at birth, weaning, and six months of age, and both GH and T4 concentrations were measured. Results showed higher values of T4 for Karakul as compared with Awassi at birth and weaning. Karakul breed was also exhibited significantly higher values of GH over Awassi breed only at weaning, while, no significant differences were observed at birth and six months of age. Karakul lambs showed higher weights as compared with Awassi lambs at all studied periods. A highly significant (p < 0.01) positive correlation was observed between T4 concentration and the weight of lambs at most studied periods. Whereas, GH did not exhibit any correlation with growth traits measured in both breeds. The elevated T4 might be one of the reasons for superiority of Karakul over Awassi breed in live body weights. This high correlation between T4 and growth traits could be used in the early selection of lambs to improve the weights of sheep at marketing.

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Section: Introductionmentioning

confidence: 99%

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Aljubouri

Al-Khafaji

Al-Shuhaib

2021

Basrah J. Agric. Sci.

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“…Basal thyroid hormone levels of total triiodothyronine (TT3) and total thyroxine (TT4) from the mare JV, UV and the foal JV at T0, T24 and T72 were determined using the Siemen's Immulite TT3 and TT4 kits (Immulite Canine TT3 and TT4; Siemens, Oakville, ON, Canada) validated for use with equine serum at the Endocrine Laboratory, Prairie Diagnostic Services, Saskatoon, SK [25,26]. The analytical sensitivity of the TT3 Immulite assay is 0.54 nmol/L.…”

Section: Measurement Of Thyroid Hormonesmentioning

confidence: 99%

Study on NGF and VEGF during the Equine Perinatal Period—Part 1: Healthy Foals Born from Normal Pregnancy and Parturition

Ellero

Lanci

Baldassarro

et al. 2022

Veterinary Sciences

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The importance of trophic factors, such as nerve growth factor (NGF), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) during the perinatal period, is now emerging. Through their functional activities of neurogenesis and angiogenesis, they play a key role in the final maturation of the nervous and vascular systems. The present study aims to: (i) evaluate the NGF and VEGF levels obtained at parturition from the mare, foal and umbilical cord vein plasma, as well as in amniotic fluid; (ii) evaluate NGF and VEGF content in the plasma of healthy foals during the first 72 h of life (T0, T24 and T72); (iii) evaluate NGF and VEGF levels at parturition in relation to the selected mares’ and foals’ clinical parameters; (iv) evaluate the relationship between the two trophic factors and the thyroid hormone levels (TT3 and TT4) in the first 72 h of life; (v) assess mRNA expression of NGF, VEGF and BDNF and their cell surface receptors in the placenta. Fourteen Standardbred healthy foals born from mares with normal pregnancies and parturitions were included in the study. The dosage of NGF and VEGF levels was performed using commercial ELISA kits, whereas NGF, VEGF and BDNF placental gene expression was performed using semi-quantitative real-time PCR. In foal plasma, both NGF and VEGF levels decreased significantly over time, from T0 to T24 (p = 0.0066 for NGF; p < 0.0001 for VEGF) and from T0 to T72 (p = 0.0179 for NGF; p = 0.0016 for VEGF). In foal serum, TT3 levels increased significantly over time from T0 to T24 (p = 0.0058) and from T0 to T72 (p = 0.0013), whereas TT4 levels decreased significantly over time from T0 to T24 (p = 0.0201) and from T0 to T72 (p < 0.0001). A positive correlation was found in the levels of NGF and VEGF in foal plasma at each time point (p = 0.0115; r = 0.2862). A positive correlation was found between NGF levels in the foal plasma at T0 and lactate (p = 0.0359; r = 0.5634) as well as between VEGF levels in the foal plasma at T0 and creatine kinase (p = 0.0459; r = 0.5407). VEGF was expressed in all fetal membranes, whereas NGF and its receptors were not expressed in the amnion. The close relationship between the two trophic factors in foal plasma over time and their fine expression in placental tissues appear to be key regulators of fetal development and adaptation to extra-uterine life.

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“…As described in Part 1 of the study [23], basal thyroid hormone levels of total triiodothyronine (TT3) and total thyroxine (TT4) from the mare JV, UV, and the foal JV at T0, T24, and T72 were determined using the Siemen's Immulite TT3 and TT4 kits (Immulite Canine TT3 and TT4; Siemens, Oakville, ON, Canada) validated for use with equine serum at the Endocrine Laboratory, Prairie Diagnostic Services, Saskatoon, SK [32,33]. The analytical sensitivity was 0.54 nmol/L for the TT3 assay and 0.15 nmol/L for the TT4 assay.…”

Section: Measurement Of Thyroid Hormonesmentioning

confidence: 99%

Study on NGF and VEGF during the Equine Perinatal Period—Part 2: Foals Affected by Neonatal Encephalopathy

Ellero

Lanci

Baldassarro

et al. 2022

Veterinary Sciences

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Neonatal Encephalopathy (NE) may be caused by hypoxic ischemic insults or inflammatory insults and modified by innate protective or excitatory mechanisms. Understanding the underlying pathophysiology is important in formulating a rational approach to diagnosis. The preliminary aim was to clinically characterize a population of foals spontaneously affected by NE. The study aimed to: (i) evaluate nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) levels in plasma samples obtained in the affected population at parturition from the mare’s jugular vein, umbilical cord vein and foal’s jugular vein, as well as in amniotic fluid; (ii) evaluate the NGF and VEGF content in the plasma of foals affected by NE during the first 72 h of life/hospitalization; (iii) evaluate NGF and VEGF levels at birth/admission in relation to selected mare’s and foal’s clinical parameters; (iv) evaluate the relationship between the two trophic factors and thyroid hormone levels (TT3 and TT4) in the first 72 h of life/hospitalization; and (v) assess the mRNA expression of NGF, VEGF and brain-derived neurotrophic factor (BDNF), and their cell surface receptors, in the placenta of mares that delivered foals affected by NE. Thirteen affected foals born from mares hospitalized for peripartum monitoring (group NE) and twenty affected foals hospitalized after birth (group exNE) were included in the study. Dosage of NGF and VEGF levels was performed using commercial ELISA kits, whereas NGF, VEGF, and BDNF placental gene expression was performed using a semi-quantitative real-time PCR. In group NE, NGF levels decreased significantly from T0 to T24 (p = 0.0447) and VEGF levels decreased significantly from T0 to T72 (p = 0.0234), whereas in group exNE, only NGF levels decreased significantly from T0 to T24 (p = 0.0304). Compared to healthy foals, a significant reduction of TT3 levels was observed in both NE (T24, p = 0.0066; T72 p = 0.0003) and exNE (T0, p = 0.0082; T24, p < 0.0001; T72, p < 0.0001) groups, whereas a significant reduction of TT4 levels was observed only in exNE group (T0, p = 0.0003; T24, p = 0.0010; T72, p = 0.0110). In group NE, NGF levels were positively correlated with both TT3 (p = 0.0475; r = 0.3424) and TT4 levels (p = 0.0063; r = 0.4589). In the placenta, a reduced expression of NGF in the allantois (p = 0.0033) and a reduced expression of BDNF in the amnion (p = 0.0498) were observed. The less pronounced decrease of the two trophic factors compared to healthy foals, their relationship with thyroid hormones over time, and the reduced expression of NGF and BDNF in placental tissues of mares that delivered affected foals, could be key regulators in the mechanisms of equine NE.

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Effects of the Glucosinolate Sinigrin in Combination With a Noniodine Supplemented Diet on Serum Iodine and Thyroid Hormone Concentrations in Nonpregnant Mares

Cited by 7 publications

References 19 publications

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Relationship of some metabolic Hormones with Increased Live Body Weight of Male and Female of Karakul and Awassi Lambs

Study on NGF and VEGF during the Equine Perinatal Period—Part 1: Healthy Foals Born from Normal Pregnancy and Parturition

Study on NGF and VEGF during the Equine Perinatal Period—Part 2: Foals Affected by Neonatal Encephalopathy

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