Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice

Jung, Un Ju; Baek, Nam‐In; Chung, Hae‐Gon; Bang, Myun‐Ho; Jeong, Tae‐Sook; Lee, Kyung Tae; Kang, Young-Jin; Lee, Mi-Kyung; Kim, Hye-Jin; Yeo, Jiyoung; Choi, Myung‐Sook

doi:10.1016/j.clnu.2007.09.009

Cited by 58 publications

(38 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16,17 The significant reduction in the plasma FFA concentration by BREE supplementation, partly, corresponded with previous studies that the BREE supplement significantly reduced total-C and FFA concentrations in the db/db mice. 8 …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Randomized Double-Blind Placebo-Controlled Trial of Powdered Brassica rapa Ethanol Extract on Alteration of Body Composition and Plasma Lipid and Adipocytokine Profiles in Overweight Subjects

Jeon

Kim²,

Shin³

et al. 2013

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

We evaluated the effects of Brassica rapa ethanol extract (BREE) on body composition and plasma lipid profiles through a randomized, double-blind, and placebo-controlled trial in overweight subjects. Fifty-eight overweight participants (age 20-50 years, body mass index23.0-24.9) were randomly assigned to two groups and served BREE (2 g/day) or placebo (starch, 2 g/day) for 10 weeks. Body compositions, nutrients intake, plasma lipids, adipocytokines, and hepatotoxicity biomarkers were assessed in all subjects at baseline and after 10 weeks of supplementation. The plasma total cholesterol (total-C) concentration was significantly increased after 10 weeks compared to the baseline in both groups. However, BREE supplementation significantly increased the high-density lipoprotein cholesterol (HDL-C) concentration and significantly reduced the total-C/HDL-C ratio, free fatty acid, and adipsin levels after 10 weeks. No significant differences were observed in body compositions, fasting blood glucose, plasma adipocytokines except adipsin, and aspartate aminotransferase and alanine aminotransferase activities between before and after trial within groups as well as between the two groups. The supplementation of BREE partially improves plasma lipid metabolism in overweight subjects without adverse effects.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Several researches reported that B. rapa ethanol extract (BREE) protects against some cancers and cisplatin-induced nephrotoxicity 6,7 as well as exerts antidiabetic effects, 8 and arvelexin, an active component of BREE, has anti-inflammatory effects. 9 However, the effectiveness of BREE has been mainly demonstrated from animal studies.…”

Section: Introductionmentioning

confidence: 99%

Randomized Double-Blind Placebo-Controlled Trial of Powdered Brassica rapa Ethanol Extract on Alteration of Body Composition and Plasma Lipid and Adipocytokine Profiles in Overweight Subjects

Jeon

Kim²,

Shin³

et al. 2013

Journal of Medicinal Food

Self Cite

View full text Add to dashboard Cite

show abstract

“…Most of the anti-obesity effects of 0.05% fucoxanthin were similar to that of 0.2% focoxanthin in high-fat fed mice, while epididymal adipocyte sizes were dramatically diminished in a dose-dependent manner along with a decrease in its mRNA expression of lipid-regulating enzymes. Dietary manipulations by high-fat diet can effect increased changes in size of epididymal fat pads of the rat [24] and mice [25]. In general, visceral fat distribution in obesity is closely linked with metabolic complications and coronary heart disease [26].…”

Section: Abcmentioning

confidence: 99%

Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice

Woo

Jeon

Shin

et al. 2009

Molecular Nutrition Food Res

Self Cite

151

104

View full text Add to dashboard Cite

This study investigated the anti-obesity effects of fucoxanthin in diet-induced obesity mice fed a high-fat diet (20% fat, wt/wt). The mice were supplemented with two doses of fucoxanthin (0.05 and 0.2%, wt/wt) for 6 wk. Fucoxanthin significantly lowered body weight and visceral fat-pads weights compared with the control group without altering food intake. In epididymal adipose tissue of fucoxanthin-fed mice, adipocyte sizes and mRNA expression of lipogenic and fatty acid beta-oxidation enzymes were significantly altered in a dose-dependent manner. Plasma leptin level was significantly lower in the fucoxanthin groups than in the control group, while the adiponectin level was elevated. Fucoxanthin significantly down-regulated various lipogenic enzyme activities in epididymal adipose tissue with a simultaneous decrease in fatty acid beta-oxidation activity. The 0.2% fucoxanthin supplement led to increase mRNA expression of uncoupling protein-1 (UCP-1) and UCP-3 in brown adipose tissue and that of UCP-2 in the epididymal white adipose tissue. However, the 0.05% fucoxanthin only elevated UCP-1 mRNA expression in epididymal white adipose tissue. These results suggest that the anti-obesity effect of fucoxanthin could be mediated by altering lipid-regulating enzymes and UCPs in the visceral fat tissues and plasma adipokine levels.

show abstract

“…Recently, we reported that arvelexin is an anti-inflammatory active compound found in Brassica rapa (Brassicaceae), an important crop species that includes the Chinese cabbage and the turnip [17]. Arvelexin significantly inhibited the LPS-induced production of NO, PGE 2 , and cytokines in macrophages.…”

Section: Introductionmentioning

confidence: 98%

Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation

Shin

Choi

Kim

et al. 2014

Chemico-Biological Interactions

View full text Add to dashboard Cite

Effects of the ethanol extract of the roots of Brassica rapa on glucose and lipid metabolism in C57BL/KsJ-db/db mice

Cited by 58 publications

References 44 publications

Randomized Double-Blind Placebo-Controlled Trial of Powdered Brassica rapa Ethanol Extract on Alteration of Body Composition and Plasma Lipid and Adipocytokine Profiles in Overweight Subjects

Randomized Double-Blind Placebo-Controlled Trial of Powdered Brassica rapa Ethanol Extract on Alteration of Body Composition and Plasma Lipid and Adipocytokine Profiles in Overweight Subjects

Anti‐obese property of fucoxanthin is partly mediated by altering lipid‐regulating enzymes and uncoupling proteins of visceral adipose tissue in mice

Anti-inflammatory effects of 7-hydroxyl-1-methylindole-3-acetonitrile, a synthetic arvelexin derivative, on the macrophages through destabilizing mPGES-1 mRNA and suppressing NF-κB activation

Contact Info

Product

Resources

About