“…Indeed, PPARα’s are found within limbic structures and expressed on tyrosine-hydroxylase positive neurons (tyrosine-hydroxylase positive) (Moreno et al, 2004; Plaza-Zabala et al, 2010). Administration of the endogenous PPARα ligand, OEA, decreases food consumption and reinforcement that is mediated by central DA neurotransmission (Fu et al, 2003; Plaza-Zabala et al, 2010; Rodriguez de Fonseca et al, 2001; Tellez et al, 2013). Further, increasing endogenous levels of ligands for PPARα or administration of agonists decrease activation of the mesolimbic DA system and attenuate the behavioral effects of nicotine and morphine (Fernandez-Espejo et al, 2009; Luchicchi et al, 2010; Mascia et al, 2011; Melis et al, 2010; Melis et al, 2008; Melis et al, 2013b; Panlilio et al, 2012).…”