Effects of the dopamine agonist cabergoline on the pulsatile and TRH-induced secretion of prolactin, LH, and testosterone in male beagle dogs

Koch, Adam J.; Hoppen, H.-O.; Dieleman, S.J.; Kooistra, Hans S.; Günzel‐Apel, A.‐R.

doi:10.1016/j.theriogenology.2005.09.013

Cited by 16 publications

(24 citation statements)

References 38 publications

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“…In the present study, CAB treatment induced a temporary reduction of basal PRL secretion, confirming our previous results (Koch et al. 2006).…”

Section: Discussionsupporting

confidence: 93%

“…Mean PRL concentrations measured in the pre‐treatment period were in accordance with the values found in previous studies (Corrada et al. 2006; Koch et al. 2006).…”

Section: Discussionsupporting

confidence: 90%

“…In the latter study, LH secretion remained unchanged while testosterone concentrations decreased. However, in male dogs, the concentrations of LH and testosterone remained unaffected by CAB administration both in the present and our previous study (Koch et al. 2006).…”

Section: Discussionsupporting

confidence: 64%

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Effects of Short‐term Hyper‐ and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and ‐Thyroid Axis and on Semen Quality in Male Beagles

Koivisto

Eschricht²,

Urhausen³

et al. 2009

Reprod Domestic Animals

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Effects of a short-term hyper- and hypoprolactinaemia on serum concentrations of LH, testosterone and semen quality in six male Beagles were investigated. Blood samples were collected at 3-day intervals for 12 weeks. The time span was divided into five 3-week periods: pre-treatment, metoclopramide (MCP) treatment (0.2 mg/kg orally three times daily), cabergoline (CAB) treatment (5 microg/kg orally once daily), post-treatment 1 and post-treatment 2. In the latter, only semen characteristics were evaluated. Semen parameters were analyzed once per week during the whole 15-week investigation time. At the end of each period, the effects of a single intravenous injection of thyrotropin-releasing hormone (TRH; 10 microg/kg) on the secretion of prolactin (PRL), LH, testosterone, thyroid-stimulating hormone and thyroxine (T4) were investigated. Pre-treatment serum PRL concentration increased under MCP (p < 0.05), followed by a decrease under CAB administration (p < 0.05). Luteinizing hormone and testosterone concentrations were not affected. Except for straight-line sperm velocity, semen quality did not differ between collection periods. A single iv TRH injection induced a significant PRL increase at 20 min in all experimental periods except during CAB treatment. Luteinizing hormone and testosterone did not show clear TRH-related changes. Basic T4 levels were significantly reduced after CAB treatment (p < 0.05). The results of the present study demonstrate that MCP-induced short-term hyperprolactinaemia in male beagles does not seriously affect the hypothalamo-pituitary axis and semen quality.

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“…In the present study, CAB treatment induced a temporary reduction of basal PRL secretion, confirming our previous results (Koch et al. 2006).…”

Section: Discussionsupporting

confidence: 93%

“…Mean PRL concentrations measured in the pre‐treatment period were in accordance with the values found in previous studies (Corrada et al. 2006; Koch et al. 2006).…”

Section: Discussionsupporting

confidence: 90%

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Effects of Short‐term Hyper‐ and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and ‐Thyroid Axis and on Semen Quality in Male Beagles

Koivisto

Eschricht²,

Urhausen³

et al. 2009

Reprod Domestic Animals

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“…In the dwarf, TRH administration failed to result in an increase in plasma prolactin concentration (maximal increase of 0.1 μg/L). In contrast, a clear rise was observed in the 2 nondwarfs (maximal increase of 10.2 and 13.2 μg/L) . Prolactin was not measured in the other dogs.…”

Section: Resultsmentioning

confidence: 74%

Central Hypothyroidism in Miniature Schnauzers

Voorbij

Leegwater

Buijtels

et al. 2015

Veterinary Internal Medicne

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BackgroundPrimary hypothyroidism is a common endocrinopathy in dogs. In contrast, central hypothyroidism is rare in this species.ObjectivesThe objective of this article is to describe the occurrence and clinical presentation of central hypothyroidism in Miniature Schnauzers. Additionally, the possible role of the thyroid‐stimulating hormone (TSH)‐releasing hormone receptor (TRHR) gene and the TSHβ (TSHB) gene was investigated.AnimalsMiniature Schnauzers with proven central hypothyroidism, based on scintigraphy, and the results of a 3‐day‐TSH‐stimulation test, or a TSH‐releasing hormone (TRH)‐stimulation test or both, presented to the Department of Clinical Sciences of Companion Animals at Utrecht University or the Department of Medicine and Clinical Biology of Small Animals at Ghent University from 2008 to 2012.MethodsRetrospective study. Pituitary function tests, thyroid scintigraphy, and computed tomography (CT) of the pituitary area were performed. Gene fragments of affected dogs and controls were amplified by polymerase chain reaction (PCR). Subsequently, the deoxyribonucleic acid (DNA) sequences of the products were analyzed.ResultsCentral hypothyroidism was diagnosed in 7 Miniature Schnauzers. Three dogs had disproportionate dwarfism and at least one of them had a combined deficiency of TSH and prolactin. No disease‐causing mutations were found in the TSHB gene and the exons of the TRHR gene of these Schnauzers.Conclusions and clinical importanceCentral hypothyroidism could be underdiagnosed in Miniature Schnauzers with hypothyroidism, especially in those of normal stature. The fact that this rare disorder occurred in 7 dogs from the same breed suggests that central hypothyroidism could have a genetic background in Miniature Schnauzers.

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“…Some steroid hormones, including testosterone, are secreted in a pulsatile manner, which suggests that the duration or timing of receptor stimulation may play an important role in determining their biological responses (Veldhuis et al, 2000;Koch et al, 2006). Cyclic patterns of gene transcription have been described for nuclear receptors in response to cognate agonists (Munck and Holbrook, 1984;Aiyar et al, 2004;Lightman et al, 2008).…”

mentioning

confidence: 99%

Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator

Vajda¹,

López²,

Rix³

et al. 2008

J Pharmacol Exp Ther

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Selective androgen receptor modulators (SARMs) are a new class of molecules in development to treat a variety of diseases. SARMs maintain the beneficial effects of androgens, including increased muscle mass and bone density, while having reduced activity on unwanted side effects. The mechanisms responsible for the tissue-selective activity of SARMs are not fully understood, and the pharmacokinetic (PK)/pharmacodynamic (PD) relationships are poorly described. Tissue-specific compound distribution potentially could be a mechanism responsible for apparent tissue selectivity. We examined the PK/PD relationship of a novel SARM, LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo[3,2-f]quinolin-7(6H)-one], in a castrated rat model of androgen deficiency.LGD-3303 has potent activity on levator ani muscle but is a partial agonist on the preputial gland and ventral prostate.LGD-3303 never stimulated ventral prostate above intact levels despite increasing plasma concentrations of compound. Tissue-selective activity was maintained when LGD-3303 was dosed orally or by continuous infusion, two routes of administration with markedly different time versus exposure profiles. Despite the greater muscle activity relative to prostate activity, local tissue concentrations of LGD-3303 were higher in the prostate than in the levator ani muscle.LGD-3303 has SARM properties that are independent of its pharmacokinetic profile, suggesting that the principle mechanism for tissue-selective activity is the result of altered molecular interactions at the level of the androgen receptor.

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Effects of the dopamine agonist cabergoline on the pulsatile and TRH-induced secretion of prolactin, LH, and testosterone in male beagle dogs

Cited by 16 publications

References 38 publications

Effects of Short‐term Hyper‐ and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and ‐Thyroid Axis and on Semen Quality in Male Beagles

Effects of Short‐term Hyper‐ and Hypoprolactinaemia on Hormones of the Pituitary, Gonad and ‐Thyroid Axis and on Semen Quality in Male Beagles

Central Hypothyroidism in Miniature Schnauzers

Pharmacokinetics and Pharmacodynamics of LGD-3303 [9-Chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an Orally Available Nonsteroidal-Selective Androgen Receptor Modulator

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