Effects of the DNA repair inhibitors, cytosine arabinoside and 3-aminobenzamide, on the frequency of radiation-induced micronuclei, nuclear buds, and nucleoplasmic bridges

Cho, Yoon Hee; Kim, Yang Jee; Lee, Sunyeong; Joung, Kyung-In; Chung, Hai Won; Kim, Sunmi; Kim, Su Young

doi:10.1007/s13258-020-00934-8

Cited by 3 publications

(1 citation statement)

References 41 publications

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“…The micronucleus assay was used to investigate the influence of IFN-γ bulk and liposome on the lymphocytes from healthy individuals and lung cancer patients at the chromosomal level. The CBMN assay has been a critical test in detection of the genotoxicity of different compounds by measuring MNi and other chromosomal abnormalities such as NPBs, a biomarker of dicentric chromosomes, and by measuring NBUDs, which are a biomarker of gene amplification [ 46 ]. MNis are cytoplasmic bodies generated as a consequence of disorders during cell cycle division.…”

Section: Discussionmentioning

confidence: 99%

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

et al. 2021

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Lung cancer is one of the main causes of death worldwide. Published data show the use of interferons (IFNs) in treating lung tumours. Also, IFNs present a potential for antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. The IFN-γ functions as an anticancer agent against various forms of cancer. This study aimed to investigate the effect of IFN-γ liposome (nano) on peripheral lymphocyte from 20 individuals in each group; lung cancer patients, compared to healthy individuals. The effectiveness of IFN- γ liposome against oxidative stress was also evaluated in this study. A concentration of 100 U·mL−1 of IFN-γ liposome was used to treat the lymphocytes in the Comet and micronucleus assays based on the preliminary test for the optimal dose. The lymphocytes from lung cancer patients presented with higher DNA damage levels than those of healthy individuals. In healthy individuals, IFN-γ liposome didn't cause to induce any DNA damage in the lymphocytes. Also, it caused a significant reduction in DNA damage in the lymphocytes from lung cancer patients in both the Comet and micronucleus assays. The 100 U·mL−1 of IFN-γ liposome significantly reduced the oxidative stress caused by H2O2 and appeared to be effective in both groups using the Comet and micronucleus assays. Results from both Comet and micronucleus assays were consistent. The data obtained indicated that IFN-γ in both forms (INF-γ bulk and INF-γ nano-liposome) may potentially be effective for the treatment of lung cancer and showed the ability of IFN-γ liposome to reduce the DNA damage more than the bulk form.

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Section: Discussionmentioning

confidence: 99%

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

et al. 2021

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Effects of radiation quality and dose rate on radiation-induced nucleoplasmic bridges in human peripheral blood lymphocytes

Hua

Cai

Lü

et al. 2021

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Dose-effect relationships of ¹²C⁶⁺ ions-induced dicentric plus ring chromosomes, micronucleus and nucleoplasmic bridges in human lymphocytes in vitro

Cai

Lü

et al. 2021

International Journal of Radiation Biology

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Effects of the DNA repair inhibitors, cytosine arabinoside and 3-aminobenzamide, on the frequency of radiation-induced micronuclei, nuclear buds, and nucleoplasmic bridges

Cited by 3 publications

References 41 publications

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

Effects of radiation quality and dose rate on radiation-induced nucleoplasmic bridges in human peripheral blood lymphocytes

Dose-effect relationships of ¹²C⁶⁺ ions-induced dicentric plus ring chromosomes, micronucleus and nucleoplasmic bridges in human lymphocytes in vitro

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Effects of the DNA repair inhibitors, cytosine arabinoside and 3-aminobenzamide, on the frequency of radiation-induced micronuclei, nuclear buds, and nucleoplasmic bridges

Cited by 3 publications

References 41 publications

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

Interferon-γ liposome: a new system to improve drug delivery in the treatment of lung cancer

Effects of radiation quality and dose rate on radiation-induced nucleoplasmic bridges in human peripheral blood lymphocytes

Dose-effect relationships of 12C6+ ions-induced dicentric plus ring chromosomes, micronucleus and nucleoplasmic bridges in human lymphocytes in vitro

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Dose-effect relationships of ¹²C⁶⁺ ions-induced dicentric plus ring chromosomes, micronucleus and nucleoplasmic bridges in human lymphocytes in vitro