Effects of the dietary linoleic acid to linolenic acid ratio for Nile tilapia (Oreochromis niloticus) breeding females

Orlando, Tamira Maria; Fontes, T. V.; Paulino, Renan Rosa; Murgas, Luís David Solis; López‐Olmeda, José Fernando; Rosa, Priscila Vieira e

doi:10.1016/j.aquaculture.2019.734625

Cited by 6 publications

(6 citation statements)

References 62 publications

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“…LA and ALA have been considered as substrates for the Fads2 and Elovl, and there is a possible metabolic competition in these two substrates for the same key enzymes . Actually, the functional characterization of isolated tilapia Δ4 Fads2 and Elovl5 acting on ALA was higher than those on LA. , Although the functional analysis of tilapia Δ6 Fads2 by heterogeneous expression exhibited 39 and 7% activity toward LA and ALA, the in vivo apparent Δ6 and Δ5 desaturase activities of tilapia acting on ALA were higher than those enzymatic activities acting on LA. , Additionally, compared to the classical “Sprecher pathway,” the “Δ4 pathway” of LC-PUFA biosynthesis is more direct to synthesize DHA from DPA substrates by Δ4 Fads2 . Thus, the Δ4 Fads2 further ensures tilapia to have highly efficient biosynthesized DHA from ALA.…”

Section: Discussionsupporting

confidence: 91%

“…19,21 Although the functional analysis of tilapia Δ6 Fads2 by heterogeneous expression exhibited 39 and 7% activity toward LA and ALA, 20 the in vivo apparent Δ6 and Δ5 desaturase activities of tilapia acting on ALA were higher than those enzymatic activities acting on LA. 15,18 Additionally, compared to the classical "Sprecher pathway," the "Δ4 pathway" of LC-PUFA biosynthesis is more direct to synthesize DHA from DPA substrates by Δ4 Fads2. 21 Thus, the Δ4 Fads2 further ensures tilapia to have highly efficient biosynthesized DHA from ALA.…”

Section: ■ Discussionmentioning

confidence: 99%

“…14 The whole-body fatty acid balance (WFAB) method was also used to assess the apparent in vivo LC-PUFA biosynthesis (elongation, desaturation, and β-oxidation) in tilapia fed diets with different lipid sources or ALA levels, which indicate that tilapia can be a net producer of LC-PUFA. 15,16 The contents of n-3 LC-PUFA in the tilapia muscle increased with the dietary increasing ALA. 17,18 These studies indicated that tilapia can biosynthesize n-6 and n-3 LC-PUFA from LA and ALA, respectively.…”

Section: ■ Introductionmentioning

confidence: 99%

“…For the basic diets with 0.5–0.6% LA, however, adding extra 0.45–0.70% α-linolenic acid (ALA) is beneficial for maximizing the growth of tilapia. , Actually, finishing diets with high ALA contents (such as linseed oil) were used to boost the nutritional value of n-3 LC-PUFA in tilapia. , Additionally, the early in vivo findings showed that the radioactive ALA or LA substrates were effectively converted into n-3 or n-6 LC-PUFA in the tilapia liver, respectively . The whole-body fatty acid balance (WFAB) method was also used to assess the apparent in vivo LC-PUFA biosynthesis (elongation, desaturation, and β-oxidation) in tilapia fed diets with different lipid sources or ALA levels, which indicate that tilapia can be a net producer of LC-PUFA. , The contents of n-3 LC-PUFA in the tilapia muscle increased with the dietary increasing ALA. , These studies indicated that tilapia can biosynthesize n-6 and n-3 LC-PUFA from LA and ALA, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Tilapia can be a Beneficial n-3 LC-PUFA Source due to Its High Biosynthetic Capacity in the Liver and Intestine

Xie

Guan

Huang

et al. 2022

J. Agric. Food Chem.

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To assess whether farmed tilapia can be a beneficial n-3 long-chain polyunsaturated fatty acid (LC-PUFA) source for human health, four diets with linoleic acid (LA) to α-linolenic acid (ALA) ratios at 9, 6, 3, and 1 were prepared to feed juveniles for 10 weeks, and the LC-PUFA biosynthetic characteristics in the liver, intestine, and brain and the muscular quality were analyzed. It was shown that the n-3 LC-PUFA levels of the intestine and liver increased in a parallel pattern with the dietary ALA levels. Correspondingly, in the fish fed diet with high ALA levels, the mRNA levels of genes related to LC-PUFA biosynthesis including fads2, elovl5, and pparα in the intestine and elovl5 in the liver were increased, and the muscular n-3 LC-PUFA levels and textures were improved. The results demonstrated that tilapia intestine and liver possess high n-3 LC-PUFA biosynthetic capacity, which suggests that farmed tilapia can be a beneficial n-3 LC-PUFA source.

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Section: Discussionsupporting

confidence: 91%

Section: ■ Discussionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Tilapia can be a Beneficial n-3 LC-PUFA Source due to Its High Biosynthetic Capacity in the Liver and Intestine

Xie

Guan

Huang

et al. 2022

J. Agric. Food Chem.

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“…Finally, the ratio of omega‐6 to omega‐3 PUFAs (abbreviated hereafter as n‐6 and n‐3) also affects consumer health; lower values of this ratio are associated with health benefits (e.g. growth rate, survival) in a wide range of taxa (Hintze et al., 2011; Orlando et al., 2020; Upadhaya et al., 2019; Wijekoon et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Cascading effects of algal warming in a freshwater community

et al. 2021

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Research on the effects of climate warming on ecological communities has focused on how temperature affects resource quantity. However, resource quality is also affected by warming, and changes in resource quality can have meaningful effects on the productivity of higher trophic levels. Aquatic communities in particular experience temperature‐mediated shifts in resource quality because the nutritional value of algae is highly sensitive to temperature. For example, the production of healthful omega‐3 polyunsaturated fatty acids (n‐3 PUFA) by algae often decreases with warming. Decreased levels of some algal PUFAs with warming have led to the hypothesis that global warming should lead to an overall decrease in productivity in aquatic communities. However, this hypothesis: (a) potentially oversimplifies the relationship between algal PUFAs and temperature, and (b) assumes that the nutritional requirements of consumers are not affected by temperature. Here, we test these assumptions using a freshwater community (Scenedesmus algae, Daphnia zooplankton, Chaoborus insects). Warming temperatures increased total algal PUFAs, but decreased algal cell size, resulting in no net effect of temperature on PUFA per algal cell. In contrast, quantities of algal neutral lipids decreased with warming. At the consumer level, Daphnia fed 12°C‐reared algae maintained higher population sizes than those fed 20°C or 28°C‐reared algae. However, the effect of algal food type diminished as Daphnia rearing temperature increased. The indirect effects of cold‐reared algae on the growth rate of Chaoborus predators were minor. These data highlight the importance of investigating the effects of temperature on both resource quality and on the nutritional needs of consumers. Our results suggest that at warmer temperatures, consumer nutritional requirements may be reduced. We caution against broad claims that the negative relationship between some algal PUFAs and temperature should result in overall declines in aquatic productivity with ongoing climate warming. A free Plain Language Summary can be found within the Supporting Information of this article.

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Essential Fatty Acids—‘Fueling Versus Controlling’

Steinberg

2022

Aquatic Animal Nutrition

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Effects of the dietary linoleic acid to linolenic acid ratio for Nile tilapia (Oreochromis niloticus) breeding females

Cited by 6 publications

References 62 publications

Tilapia can be a Beneficial n-3 LC-PUFA Source due to Its High Biosynthetic Capacity in the Liver and Intestine

Tilapia can be a Beneficial n-3 LC-PUFA Source due to Its High Biosynthetic Capacity in the Liver and Intestine

Cascading effects of algal warming in a freshwater community

Essential Fatty Acids—‘Fueling Versus Controlling’

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