Effects of the Dietary Addition of Amaranth (Amaranthus mantegazzianus) Protein Isolate on Antioxidant Status, Lipid Profiles and Blood Pressure of Rats

Lado, Maria B.; Burini, Julieta Amalia; Rinaldi, Gustavo; Añón, Marı́a Cristina; Tironi, Valeria Anahí

doi:10.1007/s11130-015-0516-3

Cited by 28 publications

(28 citation statements)

References 33 publications

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“…It has been reported that hamsters feed with amaranth protein was observed a 27% of hypercholesterolemia reduction, but when amaranth was administered in the presence of casein the observed reduction reached the 48% [22]. It was also reported that treated Wistar rats with 2.5% (w/w) of a protein isolate of Amaranthus mantegazzianus had a significant decrease in the plasma levels of CHO, TG, and oxidation when compared with control rats [23]. However, until date, no studies have been reported on the influence of amaranth on regulation of hormone profiles.…”

Section: Discussionmentioning

confidence: 98%

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Escobedo-Moratilla¹,

Velarde‐Salcedo²,

Magaña-Hernández³

et al. 2017

JFNR

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Amaranth has been claimed as functional food, but its function on obesity-related disorder is not fully known. The aim of this study was to analyse the effect of amaranth protein intake on blood lipids profile and insulin resistance in diet-induced obese mice. The effect of soybean protein was also analysed for comparative purposes. C57BL-6 mice were fed for eight weeks with regular or high fat diet. Amaranth or soybean protein isolates (10 mg/kg) were supplied via oral administration. Changes in body weight, adipose tissue, total cholesterol, triglycerides, insulin, a glucose tolerance test, as well as the expression of lipid metabolism-related genes were measured. Our results have shown that amaranth protein induces a decrease in plasma insulin in mice fed with a regular diet, whereas a decrease in triglycerides was observed in mice fed with high fat diet. Furthermore, down-regulation of Tnf-α and Res, suggested the inhibition of inflammation state. The present study demonstrates that amaranth protein, but not soybean protein, improves the obese mice health, and the hormonal modulation (Lep, Fasn, Lpl) could lead to new mechanism of action by which amaranth consumption exerts its beneficial health effect.

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Section: Discussionmentioning

confidence: 98%

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Escobedo-Moratilla¹,

Velarde‐Salcedo²,

Magaña-Hernández³

et al. 2017

JFNR

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“…The studies carried out by Lado et al. () and Escudero et al. () with Wistar rats with diets containing isolated or amaranth protein concentrates have been shown a modification of the lipid profile in animals, particularly in liver, and increases in the excretion of Cho in feces.…”

Section: Resultsmentioning

confidence: 93%

“…They are a very good source of healthy lipids, like unsaturated fatty acids, and bioactive compounds like tocopherols, squalene, and biopeptides, between others (Ogrodowska et al., ; Tovar‐Pérez, Lugo‐Radillo, & Aguilera‐Aguirre, ; Velarde‐Salcedo, Bojórquez‐Velázquez, & Barba de la Rosa, ). Different studies show that amaranth biopeptides in addition to presenting cho‐lowering activity, present antithrombotic, antioxidant, and antihypertensive activity, which is why they have a potential application in foods as a functional component (Chávez‐Jáuregui et al., ; Orsini‐Delgado et al., ; Lado, Burini, Rinaldi, Añón, & Tironi, ; Plate & Arêas, ; Quiroga, Aphalo, Nardo, & Añón, ; Sabbione, Rinaldi, Añón, & Scilingo, ).…”

Section: Introductionmentioning

confidence: 99%

“…Although there is an extensive literature on the relationship between diet and lipid metabolism (Escudero, Zirulnik, Gomez, Mucciarelli, & Giménez, ; Frota, Mendonça, Saldiva, Cruz, & Arêas, ; Grajeta, ; Lado et al., ), there is still no a clear knowledge about the action exerted by different components present in seeds—proteins and fibers among others—nor a relation between their possible mechanisms of action, evaluated by means of in vitro assays, and the effect exerted in vivo . For that reason, the aim of this work was to assess the potential Cho‐lowering capacity of amaranth in vivo in male Wistar rats fed with fat and Cho‐rich diets supplemented with an amaranth isolate (AI) or with amaranth flour (AF), during 7 and 30 days.…”

Section: Introductionmentioning

confidence: 99%

“…Food proteins are not only an essential amino acids source, they also give rise to peptides with biological activity, biopeptides, encrypted in their sequences and released during gastrointestinal digestion and/or food processing (Sánchez & Vázquez, 2017). Many studies carried out in animal models and humans have demonstrated that proteins also have a strong impact on health & Arêas, 2008;Grajeta, 1999;Lado et al, 2015), there is still no a clear knowledge about the action exerted by different components present in seeds-proteins and fibers among others-nor a relation between their possible mechanisms of action, evaluated by means of in vitro assays, and the effect exerted in vivo. For that reason, the aim of this work was to assess the potential Cho-lowering capacity of amaranth in vivo in male Wistar rats fed with fat and Cho-rich diets supplemented with an amaranth isolate (AI) or with amaranth flour (AF), during 7 and 30 days.…”

Section: Introductionmentioning

confidence: 99%

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Effect of the Incorporation of Amaranth (Amaranthus Mantegazzianus) into Fat‐ and Cholesterol‐Rich Diets for Wistar Rats

Sisti

Scilingo

Añón

2019

Journal of Food Science

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The hypocholesterolemic effect of amaranth was studied in male Wistar rats fed a high‐fat diet that was supplemented with amaranth flour, AF, or isolated protein, AI. Likewise, an in vitro test was carried out, in which the capacity of the AI, AF, the digested isolate, DAI, and the digested amaranth flour, DAF, to displace the cholesterol of the model micelles was evaluated. The in vivo results showed an increase in the excretion of cholesterol through feces (77% for AF7; 23% and 108% for AI30 and AF30, respect control) and a decrease in the content of hepatic cholesterol (98% for AF7; 96% and 53% for AI30 and AF30 respect control); whereas in vitro it was shown that both AF and DAF have greater power to displace cholesterol than the AI and DAI (IC50 0.1, 0.71, 0.2, and 2.1 for AF, DAF, AI, and DAI, respectively). These evidences show that the proteins and fibers of amaranth have an effect on cholesterol metabolism. Practical Application Nowadays, consumers give great importance to the effect that food has on health. The results shown in this work evidence the potential hypocholesterolemic activity presented by amaranth, this is of great importance due to the increase in the incidence of dyslipidemia in the world population and the importance of amaranth as a nonextensive crop of excellent agronomic, nutritional, and bioactive properties suitable for preparation of functional foods.

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In vivo and in vitro model studies on noodles prepared with antioxidant-rich pseudocereals

et al. 2019

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Pseudocereals are recently positioned at the forefront of interest, as they are eminent sources of several beneficial bioactive components, such as flavonoids. Noodles of specific composition comprising buckwheat and amaranth have been involved in this research. The aim of presented study was to provide authentic tools in order to estimate the actual behaviour of polyphenols of the special noodles throughout the digestion process. In vitro and in vivo digestion models studies were performed with wheat flour noodles fortified with antioxidant rich pseudocereals. Five noodle variants were prepared with supplementation of different flours of amaranth and buckwheat with wheat flour ranging from 5 to 30%. To reveal the effect of human consumption on polyphenols uptake and real biological impacts, in vitro and in vivo experiments were carried out. Different assays were applied to monitor the release of antioxidants in each gastrointestinal phase. Fortification didn't change the cooking quality of noodles, but slightly affected the colour and improved the total polyphenol content (597-920 mg GAE/ kg), and the antioxidant capacity (3.47-7.23 mM Fe 2+ /kg) of the noodles. It was established that total polyphenol content and antioxidant capacity exhibited continuous increase in the whole gastrointestinal tracts, due to their gradual release from food matrix. Most pronounced antioxidant capacity was observed in noodles with 30% buckwheat fortification. In vivo model-experiments confirmed the presence of polyphenols in plasma as well, thus their absorption might be accomplished. Therefore, the biological values of these samples were enhanced during digestion. Supplementation prepared pseudocereal resulted in products with improved nutritional properties.

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Effects of the Dietary Addition of Amaranth (Amaranthus mantegazzianus) Protein Isolate on Antioxidant Status, Lipid Profiles and Blood Pressure of Rats

Cited by 28 publications

References 33 publications

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Amaranth Protein Improves Lipid Profile and Insulin Resistance in a Diet-induced Obese Mice Model

Effect of the Incorporation of Amaranth (Amaranthus Mantegazzianus) into Fat‐ and Cholesterol‐Rich Diets for Wistar Rats

In vivo and in vitro model studies on noodles prepared with antioxidant-rich pseudocereals

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