Effects of the CLIP fragment ACTH 20–24 on the duration of REM sleep episodes

Wetzel, Wolfram; Wagner, Thomas; Vogel, D.; Demuth, H.U.; Balschun, Detlef

doi:10.1016/s0143-4179(97)90018-4

Cited by 12 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, in all studies, REM sleep increased following injection of CLIP in rats [50,52-54]. In addition, whereas the duration of bouts of REM sleep decreased with increasing PCSK2 expression in owls, CLIP increased the duration of REM sleep bouts in rats [53]. To the extent that these findings in adult mammals receiving icv injections of α-MSH and CLIP translate to young owls, they do not support the notion that the production of these peptides in the follicles accounts for the relationships observed between PCSK2 expression and sleep.…”

Section: Discussionmentioning

confidence: 99%

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

et al. 2013

View full text Add to dashboard Cite

BackgroundIntra-specific variation in melanocyte pigmentation, common in the animal kingdom, has caught the eye of naturalists and biologists for centuries. In vertebrates, dark, eumelanin pigmentation is often genetically determined and associated with various behavioral and physiological traits, suggesting that the genes involved in melanism have far reaching pleiotropic effects. The mechanisms linking these traits remain poorly understood, and the potential involvement of developmental processes occurring in the brain early in life has not been investigated. We examined the ontogeny of rapid eye movement (REM) sleep, a state involved in brain development, in a wild population of barn owls (Tyto alba) exhibiting inter-individual variation in melanism and covarying traits. In addition to sleep, we measured melanistic feather spots and the expression of a gene in the feather follicles implicated in melanism (PCSK2).ResultsAs in mammals, REM sleep declined with age across a period of brain development in owlets. In addition, inter-individual variation in REM sleep around this developmental trajectory was predicted by variation in PCSK2 expression in the feather follicles, with individuals expressing higher levels exhibiting a more precocial pattern characterized by less REM sleep. Finally, PCSK2 expression was positively correlated with feather spotting.ConclusionsWe demonstrate that the pace of brain development, as reflected in age-related changes in REM sleep, covaries with the peripheral activation of the melanocortin system. Given its role in brain development, variation in nestling REM sleep may lead to variation in adult brain organization, and thereby contribute to the behavioral and physiological differences observed between adults expressing different degrees of melanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The axonal release prepares the brain to sleep, due to increased and cumulative synthesis of hypnogenic substances in the arcuate nucleus and pre-optic area (Jouvet, 1999), initiating a cascade of genomic events (Garcia de Yebenes et al, 1994; Churruca et al, 2008). In the arcuate nucleus, serotonin induces the synthesis of corticotropin-like intermediate lobe peptide (CLIP or ACTH 18–39 ), a pro-opiomelanocortin (POMC) derivative (Cespuglio et al, 1992), claimed to be a major mediator of stress-induced sleep rebound, due to its well-known REMS inducing properties (Wetzel et al, 1994, 1997, 2003; Cespuglio et al, 1995; Bonnet et al, 1997). Thus, increased serotonin transmission induces POMC mRNA in the arcuate nucleus, which, in turn, is cleaved originating several derivatives, including ACTH, α-melanocyte stimulating hormone (α-MSH) and CLIP (Figure 3; Cespuglio et al, 1995; Bonnet et al, 1997).…”

Section: Mechanisms and Mediators Of Stress-induced Sleep Changesmentioning

confidence: 99%

“…In fact, the expected increase of ph-CLIP in the arcuate nucleus is absent in adrenalectomized rats, which might explain the smaller REMS rebound seen under this condition (Bonnet et al, 2000). Finally, exogenous administration of CLIP or its N-terminal fragments ACTH 20–24 and ACTH 18–24 induces a significant increase of REMS, by increasing episode length (Wetzel et al, 1994, 1997). …”

Section: Mechanisms and Mediators Of Stress-induced Sleep Changesmentioning

confidence: 99%

REM Sleep Rebound as an Adaptive Response to Stressful Situations

Suchecki¹,

Tiba²,

Machado³

2012

Front. Neur.

View full text Add to dashboard Cite

Stress and sleep are related to each other in a bidirectional way. If on one hand poor or inadequate sleep exacerbates emotional, behavioral, and stress-related responses, on the other hand acute stress induces sleep rebound, most likely as a way to cope with the adverse stimuli. Chronic, as opposed to acute, stress impairs sleep and has been claimed to be one of the triggering factors of emotional-related sleep disorders, such as insomnia, depressive- and anxiety-disorders. These outcomes are dependent on individual psychobiological characteristics, conferring even more complexity to the stress-sleep relationship. Its neurobiology has only recently begun to be explored, through animal models, which are also valuable for the development of potential therapeutic agents and preventive actions. This review seeks to present data on the effects of stress on sleep and the different approaches used to study this relationship as well as possible neurobiological underpinnings and mechanisms involved. The results of numerous studies in humans and animals indicate that increased sleep, especially the rapid eye movement phase, following a stressful situation is an important adaptive behavior for recovery. However, this endogenous advantage appears to be impaired in human beings and rodent strains that exhibit high levels of anxiety and anxiety-like behavior.

show abstract

“…It is worth mentioning that REMS induced by CLIP, more precisely the amino-terminal fragment ACTH 20–24 (Val-Lys-Tyr-Pro), is characterized by extremely long episodes, usually above 7 min. This effect on REMS is not obtained with ACTH (ACTH 1–39 ) or other active fragments, such as ACTH 18–24 (60). …”

Section: Hormonal Regulation Of Stress-induced Sleep Reboundmentioning

confidence: 91%

“…CLIP is a POMC derivative, well known for inducing long REMS episodes (59, 60). ACTH cleavage to CLIP and α-MSH is mediated by prohormone convertase 2 (PC2) and is stimulated by serotonin, via 5-HT 2C receptors (61–63).…”

Section: Hormonal Regulation Of Stress-induced Sleep Reboundmentioning

confidence: 99%

Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

Machado

Suchecki

2016

Front. Endocrinol.

View full text Add to dashboard Cite

Sleep homeostasis depends on the length and quality (occurrence of stressful events, for instance) of the preceding waking time. Forced wakefulness (sleep deprivation or sleep restriction) is one of the main tools used for the understanding of mechanisms that play a role in homeostatic processes involved in sleep regulation and their interrelations. Interestingly, forced wakefulness for periods longer than 24 h activates stress response systems, whereas stressful events impact on sleep pattern. Hypothalamic peptides (corticotropin-releasing hormone, prolactin, and the CLIP/ACTH18–39) play an important role in the expression of stress-induced sleep effects, essentially by modulating rapid eye movement sleep, which has been claimed to affect the organism resilience to the deleterious effects of stress. Some of the mechanisms involved in the generation and regulation of sleep and the main peptides/hypothalamic hormones involved in these responses will be discussed in this review.

show abstract

Effects of the CLIP fragment ACTH 20–24 on the duration of REM sleep episodes

Cited by 12 publications

References 21 publications

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

Linking melanism to brain development: expression of a melanism-related gene in barn owl feather follicles covaries with sleep ontogeny

REM Sleep Rebound as an Adaptive Response to Stressful Situations

Neuroendocrine and Peptidergic Regulation of Stress-Induced REM Sleep Rebound

Contact Info

Product

Resources

About