Effects of the circadian rhythm of corticosteroids on leukocyte-endothelium interactions in the AM and PM

House, Steven; Ruch, Stacey; Koscienski, Walter F.; Rocholl, Christian W.; Moldow, Roberta L.

doi:10.1016/s0024-3205(97)00167-7

Cited by 24 publications

(8 citation statements)

References 33 publications

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“…Specifically, transient addition of FMLP causes a reduction of WBC flux and more than doubles the number of adherent leukocytes (LEA) in venules. This is consistent with previous experiments in our laboratory (Nazziola and House 1992;House et al 1997). The increased adhesion after exposure to the chemoactivator FMLP has been attributed to conformational changes in or increased surface expression of the integrins CD11/CD18 on polymorphonuclear leukocytes (Tonnesen et al 1989;Graham and Brown 1991).…”

Section: Discussionsupporting

confidence: 92%

“…Leukocytes sticking to the endothelium for more than 5 seconds during the duration of the hemodynamic measurements were counted as adhering WBCs and were expressed as number per 100 m vessel length. Previous experiments in our laboratory indicate that greater than 94% of the cells that adhere for more than 5 seconds adhere for at least 30 seconds (House et al 1997). The shorter time period was selected because LEA for even 1 second has a significant impact on vascular resistance Lipowksy 1987, 1988).…”

Section: Animal Preparation and Intravital Microscopymentioning

confidence: 99%

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Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response

House

Guidon²,

Perdrizet³

et al. 2001

Cell Stress Chaper

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Heat and a variety of other stressors cause mammalian cells and tissues to acquire cytoprotection. This transient state of altered cellular physiology is nonproliferative and antiapoptotic. In this study, male Wistar rats were stress conditioned with either stannous chloride or gallium nitrate, which have immunosuppressive effects in vivo and in vitro, or heat shock, the most intensively studied inducer of cytoprotection. The early stages of inflammation in response to topical suffusion of mesentery tissue with formyl-methionyl-leucyl-phenylalanine (FMLP) were monitored using intravital microscopy. Microvascular hemodynamics (venular diameter, red blood cell velocity [Vrbc], white blood cell [WBC] flux, and leukocyte-endothelial adhesion [LEA]) were used as indicators of inflammation, and tissue levels of inducible Hsp70, determined using immunoblot assays, provided a marker of cytoprotection. None of the experimental treatments blocked decreases in WBC flux during FMLP suffusion, an indicator of increased low-affinity interactions between leukocytes and vascular endothelium known as rolling adhesion. During FMLP suffusion LEA, an indicator of firm attachment between leukocytes and vascular endothelial cells increased in placebo and gallium nitrate-treated animals but not in heat- and stannous chloride-treated animals, an anti-inflammatory effect. Hsp70 was not detected in aortic tissue from placebo and gallium nitrate-treated animals, indicating that Hsp70-dependent cytoprotection was not present. In contrast, Hsp70 was detected in aortic tissues from heat- and stannous chloride-treated animals, indicating that these tissues were in a cytoprotected state that was also an anti-inflammatory state.

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Section: Discussionsupporting

confidence: 92%

Section: Animal Preparation and Intravital Microscopymentioning

confidence: 99%

Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response

House

Guidon²,

Perdrizet³

et al. 2001

Cell Stress Chaper

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“…Indeed, in models of TNF-α-induced vaso-occlusion in SCD mice and LPS-induced lethality, we have found that circadian rhythms modulate the robustness of the inflammatory response with implications on survival. While we recognize potential mechanistic differences between atherosclerosis and inflammatory models studied herein, these data are in line with prior studies that have shown persistent oscillations in the susceptibility of mice to bacterial infection and inflammatory leukocyte trafficking (Castanon-Cervantes et al, 2010; Feigin et al, 1969; Gibbs et al, 2011; Halberg et al, 1960; House et al, 1997; Keller et al, 2009; Liu et al, 2006; Shackelford and Feigin, 1973; Silver et al, 2012). Sensitivity to inflammatory stimuli at times of higher SNS tone likely interacts at multiple levels encompassing local neural input as we describe herein, endogenous rhythms within tissues as well as interactions with humoral factors and the parasympathetic nervous system.…”

Section: Discussionsupporting

confidence: 88%

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

et al. 2012

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SUMMARY The multistep sequence leading to leukocyte migration is thought to be locally regulated at the inflammatory site. Here, we show that broad systemic programs involving long-range signals from the sympathetic nervous system (SNS) delivered by adrenergic nerves, regulate rhythmic recruitment of leukocytes in tissues. Constitutive leukocyte adhesion and migration in murine bone marrow (BM) and skeletal muscle microvasculature fluctuated with circadian peak values at night. Migratory oscillations, altered by experimental jetlag, were implemented by perivascular SNS fibers, acting on β-adrenoreceptors expressed on non-hematopoietic cells, and leading to tissue-specific, differential circadian oscillations in the expression of endothelial cell adhesion molecules and chemokines. We showed that these rhythms have physiological consequences by alteration of hematopoietic cell recruitment and overall survival in models of septic shock, sickle cell vaso-occlusion and BM transplantation. These data provide unique insight in the leukocyte adhesion cascade and the potential for time-based therapeutics for transplantation and inflammatory diseases.

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“…Figure 1A shows the time course of the values of total PECs and peritoneal neutrophils after injection of a 10% casein solution. To eliminate the influence of circadian rhythms on leukocyte function (13,40), PECs were collected between 1200 and 1500. PEC values increased rapidly, and a maximum response was observed 15 h after injection.…”

Section: Methodsmentioning

confidence: 99%

Role of hypothermia induced by tumor necrosis factor on apoptosis and function of inflammatory neutrophils in mice

Mizuno

Kannan

Tokunaga

et al. 2000

American Journal of Physiology-Regulatory, Integrative and Comp

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Changes in body temperature and cell infiltration, mediated by cytokines including tumor necrosis factor-alpha (TNF-alpha), occur during inflammation, but a role of body temperature on inflammatory responses remains obscure. Intraperitoneal injection of 10% casein to mice resulted in transient hypothermia followed by neutrophil accumulation in peritoneal cavities. Peritoneal TNF-alpha was rapidly raised, and pretreatment of mice with an anti-TNF-alpha antibody promoted temperature restoration and partially inhibited neutrophil accumulation. To investigate direct effects of body temperature on neutrophils, peritoneal or peripheral blood neutrophils were cultured at 35 degrees C or 37 degrees C with or without recombinant murine TNF-alpha (100 ng/ml) or a protein synthesis inhibitor cycloheximide (1 microg/ml). Significant inhibition of spontaneous and TNF-alpha-induced apoptosis was obtained at 35 degrees C compared with 37 degrees C, an effect that was not altered by the addition of cycloheximide. Moreover, phagocytic ability of peritoneal neutrophils was significantly enhanced by incubating them at the lower temperature. These results indicate that mild hypothermia induced by endogenous TNF-alpha has enhancing roles on neutrophil survival and function during peritoneal inflammation.

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Effects of the circadian rhythm of corticosteroids on leukocyte-endothelium interactions in the AM and PM

Cited by 24 publications

References 33 publications

Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response

Effects of heat shock, stannous chloride, and gallium nitrate on the rat inflammatory response

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

Role of hypothermia induced by tumor necrosis factor on apoptosis and function of inflammatory neutrophils in mice

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