Effects of the Catechol-O-Methyltransferase Val108/158Met and Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms on Prostate Cancer Susceptibility

Abstract

A AB BS S T TR RA AC CT T OOb b j je ec c t ti i v ve e: : Pros ta te can cer is a mul ti fac to ri al in he ri ted di se a se af fec ting one in six men in in dus tri al co un tri es. A number of mu ta ti ons in key pro te ins of the cell cycle mac hi nery or sig nal trans duc ti on path ways ha ve already be en as so ci a ted with pros ta te can cer; but re cently, a number of poly morp hisms in pro te ins that func ti on in less po pu lar cel lu lar path ways have been in ves ti ga ted as pos sib le risk fac tors. In this study, we eva lu a ted the ef fects of two ge ne poly morp hisms in enz ymes func ti o ning in dis tinct me ta bo lic path ways on pros ta te can cer sus cep ti bi lity. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : Al le le and ge noty pe as so ci a ti ons of the COMT Val108/158Met and MTHFR C677T ge ne poly morphisms we re stu di ed in a to tal of 112 Tur kish pros ta te can cer pa ti ents who constituted our study group while 145 he althy ma les cons ti tu ted our con trol gro up. Ge no mic DNA was iso la ted from the pe rip he ral blo od le u kocy tes of the sub jects and analy zed by two dif fe rent re al-ti me polymerase chain reaction as says. R Re e s su ul lt ts s: : The fre qu ency of the he te rozy go us COMT G/A and the ho mozy go us MTHFR T/T ge noty pes we re hig her in the study gro up compared to the con trol gro up (47.3% ver sus 34.5%; and 14.3% ver sus 7.6%, res pec ti vely). Pros ta te can cer sub jects with the he te rozy go us MTHFR C/T ge noty pe had hig her prostate specific antigen va lu es. Ne vert he less, no sta tis ti cally sig ni fi cant as soci a ti on was found between the se poly morp hisms alo ne or in com bi na ti on and the risk of de ve lo ping pros ta te can cer. C Co on nc c l lu u s si i o on n: : We sug gest that func ti o nal ge ne poly morp hisms in me ta bo lic pro te ins pre dis po se sub jects to in cre a sed risk of de ve lo ping can cer; but, not as strong as mu ta ti ons in pro toon co ge nes or tu mor-sup pres sor ge nes.K Ke ey y W Wo or rd ds s: : Pros ta tic ne op lasms; pros ta tic ne op lasms; ca tec hol O-methy ltrans fe ra se; meth yle ne tet rahy dro fo la te re duc ta se (NADPH2) Ö ÖZ ZE ET T A Am ma aç ç: : Pros tat kan se ri en düs tri leş miş ül ke ler de her al tı er kek ten bi ri ni et ki le yen mul ti fak tö -ri yel ka lıt sal bir has ta lık tır. Ha li ha zır da hüc re dön gü sü çar kı nın ve ya sin yal ak tar ma yo lak la rı nın anah tar pro te in le rin de ki pek çok mu tas yon pros tat kan se ri ile iliş ki len di ril miş tir; fa kat, son za manlar da da ha az po pü ler hüc re sel yo lak lar da iş lev ya pan pro te in ler de ki pek çok po li mor fizm de ola sı risk fak tör le ri ola rak araş tı rıl mak ta dır. Bu ça lış ma da, pros tat kan se ri ne yat kın lık ya ra ta bi le cek fark lı meta bo lik yo lak lar da yer alan en zim ler de ki iki gen po li mor fiz mi nin et ki le ri ni de ğer len dir dik. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Ça lış ma gru bu mu zu oluş tu ran top lam 112 Türk...

Associations between MTHFR gene polymorphisms (C677T and A1298C) and genetic susceptibility to prostate cancer: a systematic review and meta-analysis

“…Frontiers in Genetics frontiersin.org Frontiers in Genetics frontiersin.org Collin et al, 2009;Muslumanoglu et al, 2009;Cai et al, 2010;Safarinejad et al, 2010;Wu et al, 2010;Kosova et al, 2011;Küçükhüseyin et al, 2011;Fard-Esfahani et al, 2012;Kobayashi et al, 2012;Mandal et al, 2012;Vidal et al, 2012;de Vogel et al, 2013;López-Cortés et al, 2013;Ghasemi et al, 2014;Wu et al, 2016;TELLOUCHE-BOUHOUHOU et al, 2018;Mouhoub-Terrab et al, 2023) included 12,455 cases and 13,900 controls with the C677T polymorphism and 6,396 cases and 8,913 controls with the A1298C polymorphism (Table 1). The participants included Caucasians, Asians, and individuals of mixed races.…”