Effects of the C825T polymorphism of the GNB3 gene on body adiposity and blood pressure in fertile and menopausal women: a population-based study

Casíglia, Edoardo; Tikhonoff, Valérie; Caffi, Sandro; Martini, Bortolo; Guidotti, Federica; Bolzon, Monica; Bascelli, Anna; D’Este, D; Mazza, Alberto; Pessina, Achille C.

doi:10.1097/hjh.0b013e3282f2b90c

Cited by 25 publications

(24 citation statements)

References 33 publications

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“…The SNP C825T of the GNβ3 gene has been reported to be associated with elevated metabolic indexes in different groups of patients suffering from hypertension, diabetes or cardiovascular disease (Brand et al, 2003;Casiglia et al, 2008;Danoviz et al, 2006;Hayakawa et al, 2007;Kopf et al, 2008;Meirhaeghe et al, 2005). Moreover, the variant has also been found to be associated with medication-induced metabolic disturbances (Hauner et al, 2003;Peters et al, 2008;Souza et al, 2008;Wang et al, 2005).…”

Section: Discussionmentioning

confidence: 96%

Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

et al. 2011

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Section: Discussionmentioning

confidence: 96%

Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

et al. 2011

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“…[8][9][10][11][12] A group of 1438 subjects matched with cases for age (Ϯ 3 years) and sex, who had no history of cancer and had not experienced either venous (including SVT) or arterial thromboembolic disorders before the beginning of the observation, served as study controls. For 36 cases, only 1 matched control could be identified.…”

Section: Controlsmentioning

confidence: 99%

The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs

Prandoni

Casíglia

Tikhonoff

et al. 2011

Blood

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Although it has been clearly demonstrated that venous thromboembolism is associated with an increased risk of subsequent overt cancer and arterial cardiovascular events in comparison with control populations, whether this association also applies to patients with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs is unknown. In 737 consecutive patients with isolated SVT not involving the sapheno-femoral junction, we conducted a retrospective investigation to assess the rate of cancer and that of arterial cardiovascular events occurring during follow-up. The event rates were compared with those occurring in 1438 controls having comparable characteristics. Both cases and controls were followed-up for an average period of 26 ؎ 8 months (range, 3-45). Malignancy was diagnosed in 26 cases (3.5%) and 56 controls (3.9%), leading to a hazard ratio of 0.86 (95% confidence interval, 0.55%-1.35% IntroductionAlthough it has been clearly demonstrated that venous thromboembolism (VTE) is associated with an increased risk of subsequent overt cancer 1 and arterial cardiovascular disorders 2 in comparison with control populations, it is unknown whether this association also applies to patients presenting with isolated (ie, without concomitant involvement of the deep vein system) superficial vein thrombosis (SVT) in the legs. On the basis of anecdotal reports 3 and findings from case-series, 4,5 SVT is generally perceived as a marker of occult malignancy. However, a recent enquiry conducted in The Netherlands in 250 patients with spontaneous SVT and in matched control individuals identified through a search in an electronic database from a few primary health care centers failed to show an increase in the risk of cancer in patients with SVT. 6 In the recently published Calisto study, ϳ 3000 patients with isolated SVT were randomized to receive either fondaparinux or placebo for 45 days. 7 The study showed a remarkable advantage of fondaparinux over placebo for prevention of VTE events during this period. In 737 consecutive patients recruited in 32 centers that agreed to participate in this substudy, a retrospective enquiry was conducted to assess the rate of cancer and that of arterial thromboembolic events occurring after randomization. The event rates were compared with those occurring in 1438 controls having comparable characteristics recruited from the general population of northern Italy. Both cases and controls were followed-up for an average period of more than 2 years. Methods PatientsThe Calisto study recruited 3002 patients 18 years of age or older between March 2007 and May 2009 who had acute symptomatic isolated SVT of the lower extremities at least 5 cm long, as confirmed by standardized compression ultrasonography. 7 Consecutive patients recruited in each of 32 centers that agreed to participate in this substudy were eligible for the current investigation. Patients who had a history of cancer, symptomatic VTE, or symptomatic arterial cardiovascular ...

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“…The mechanism whereby the 825T variant may lead to hypertension remains unknown, but it may involve an increase of Na-H exchanger activity (Siffert, 1996) which enhanced renal sodium reabsorption and induced the BP increase. Several studies have demonstrated that the 825T allele of GNB3 is associated with hypertension (Benjafiel et al, 1998, Beige et al, 1999, Dong et al, 1999, Hengstenberg et al, 2001, Timberlake et al, 2001, Casiglia et al, 2008. Together, these studies highlight the importance of the GBN3/C825T variant gene in EH.…”

Section: G Proteinsmentioning

confidence: 72%

“…A polymorphism C3T at nucleotide 825 in exon 10 of the 3 subunit of GTP binding protein (GNB3/C825T) has been identified (Bohm et al, 1997). This polymorphism is associated with enhanced intracellular signal transduction and has been reported to be associated with a variety of cardiovascular risk factors, including hypertension , Schunkert et al, 1998, Benjafield et al, 1998, obesity , Casiglia et al, 2008, diabetes (Bluthner et al, 1999) or dyslipidemia (Ishikawa et al, 2000, Hayakawa et al, 2007. A significantly higher frequency of the T allele has been identified in EH (Beige et al, 1999, Siffert, 1996.…”

Section: G Proteinsmentioning

confidence: 99%

Candidate Genes in Hypertension

Soualmia¹

2012

Genetics and Pathophysiology of Essential Hypertension

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Effects of the C825T polymorphism of the GNB3 gene on body adiposity and blood pressure in fertile and menopausal women: a population-based study

Cited by 25 publications

References 33 publications

Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers — A SPECT study

The risk of subsequent cancer and arterial cardiovascular events in patients with superficial vein thrombosis in the legs

Candidate Genes in Hypertension

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