Effects of the ATP-dependent K ( )-channel effectors pinacidil and glibenclamide on liver tissue in an experimental model of epilepsy: A histopathological study
Abstract:It is known that most of the antiepileptic drugs have negative effects on the liver. Pinacidil is a nonselective opener of KATP channels, including the plasma membrane and mitochondria. Glibenclamide is an ATP -dependent K channel blocker ensuring the intake of calcium. Our aim in this experimental study was to examine the effects of pinacidil and glibenclamide on the liver tissue of rats with focal epilepsy. Method: Sixty male Sprague Dawley rats (2-4 months old, 200-250 gr) were used in the study. The rats w… Show more
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