Effects of the aspect ratio of multi-walled carbon nanotubes on the structure and properties of regenerated collagen fibers

Ding, Changkun; Du, Jia; Cao, Yuemiao; Yue, Chengfei; Cheng, Bowen

doi:10.1016/j.ijbiomac.2018.12.144

Cited by 20 publications

(6 citation statements)

References 50 publications

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“…The aforementioned peaks were detected in the spectrum of CRT network 4VBC-MA*, whereby the triple helix-related diffraction peak (2 θ ~ 8°) was found at a slightly lower angle compared to the case of the CRT sample, while the peak associated with the single polyproline-II helices was recorded at an increased angle. These observations confirm the presence of collagen triple helices in the crosslinked state, although with an increased lateral triple helix packing [ 36 ] and decreased axial periodicity with respect to the native CRT configuration. This result correlates with the introduction of bulky 4VBC residues on the CRT backbone.…”

Section: Resultssupporting

confidence: 83%

“…To further explore the CRT organisation in the crosslinked state, WAXS measurements were performed on the dry UV-cured networks. The WAXS spectrum of type I rat tail collagen displays three main peaks [ 17 , 20 , 28 , 36 ], identifying the intermolecular lateral packing of collagen triple helices ( d ~ 1.1 nm, 2 θ ~ 8°), the isotropic amorphous region ( d ~ 0.5 nm, 2 θ ~ 20°) and the axial periodicity ( d ~ 0.29 nm, 2 θ ~ 31°) of polypeptide subunits along a single polyproline-II chain ( Figure 3 B). The aforementioned peaks were detected in the spectrum of CRT network 4VBC-MA*, whereby the triple helix-related diffraction peak (2 θ ~ 8°) was found at a slightly lower angle compared to the case of the CRT sample, while the peak associated with the single polyproline-II helices was recorded at an increased angle.…”

Section: Resultsmentioning

confidence: 99%

“…Samples F-4VBC (Ø = 54 ± 5 μm), F-GMA (Ø: 39 ± 10) and F-4VBC-MA (Ø = 51 ± 5 μm) displayed significantly lower fibre diameters with respect to the sample of F-C (Ø = 80 ± 3 μm) ( Table 2 ), a result that agrees with previous trends in solution viscosity and with the effect of solution viscosity on fibre diameter [ 7 , 10 , 35 ]. Higher resolution images revealed the presence of grooves on the surface of both sample F-4VBC ( Figure 4 B) and F-GMA ( Figure 4 E), which may be attributed to the shear stress generated during wet spinning in light of the relatively high solution viscosity [ 21 , 36 ]. Nevertheless, the aforementioned values of fibre diameter are comparable to previously reported wet spun collagen fibres [ 38 , 39 , 40 ], indicating that the covalent functionalisation introduced to the CRT backbone at the molecular scale does not significantly affect the fibre microscale.…”

Section: Resultsmentioning

confidence: 99%

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Hierarchically Assembled Type I Collagen Fibres as Biomimetic Building Blocks of Biomedical Membranes

et al. 2021

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Wet spinning is an established fibre manufacturing route to realise collagen fibres with preserved triple helix architecture and cell acceptability for applications in biomedical membranes. However, resulting fibres still need to be chemically modified post-spinning to ensure material integrity in physiological media, with inherent risks of alteration of fibre morphology and with limited opportunities to induce fibrillogenesis following collagen fixation in the crosslinked state. To overcome this challenge, we hypothesised that a photoactive type I collagen precursor bearing either single or multiple monomers could be employed to accomplish hierarchically assembled fibres with improved processability, macroscopic properties and nanoscale organisation via sequential wet spinning and UV-curing. In-house-extracted type I rat tail collagen functionalised with both 4-vinylbenzyl chloride (4VBC) and methacrylate residues generated a full hydrogel network following solubilisation in a photoactive aqueous solution and UV exposure, whereby ~85 wt.% of material was retained following 75-day hydrolytic incubation. Wide-angle x-ray diffraction confirmed the presence of typical collagen patterns, whilst an averaged compression modulus and swelling ratio of more than 290 kPa and 1500 wt.% was recorded in the UV-cured hydrogel networks. Photoactive type I collagen precursors were subsequently wet spun into fibres, displaying the typical dichroic features of collagen and regular fibre morphology. Varying tensile modulus (E = 5 ± 1 − 11 ± 4 MPa) and swelling ratio (SR = 1880 ± 200 − 3350 ± 500 wt.%) were measured following post-spinning UV curing and equilibration with phosphate‑buffered saline (PBS). Most importantly, 72-h incubation of the wet spun fibres in PBS successfully induced renaturation of collagen-like fibrils, which were fixed following UV-induced network formation. The whole process proved to be well tolerated by cells, as indicated by a spread-like cell morphology following a 48-h culture of L929 mouse fibroblasts on the extracts of UV-cured fibres.

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Section: Resultssupporting

confidence: 83%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hierarchically Assembled Type I Collagen Fibres as Biomimetic Building Blocks of Biomedical Membranes

et al. 2021

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“…2a, for the FT-IR spectrum of the PNIPAm/CMC/CMCNT hydrogel, the broad and strong absorption band at 3556 cm −1 is assigned to the stretching vibration of N–H (from PNIPAm) and O–H (from CMC and the structured water); strong and narrow CO stretching bands of –CONH 2 , –COOH, and –CH 2 COOH of PNIPAm, CMCNTs, and CMC are observed at 1475–1809 cm −1 . 29,38 For the PNIPAm hydrogel and PNIPAm/CMC hydrogel, no vibration absorption peak is found at 3027–3131 cm −1 due to the lack of CMCNTs, 39 while the PNIPAm/CMC hydrogel and PNIPAm/CMC/CMCNT hydrogel exhibit a distinct peak at 918 cm −1 , which is related to the O–H bending vibration of CMC. 40 It can be seen from Fig.…”

Section: Resultsmentioning

confidence: 99%

A mimosa-inspired photothermal-responsive multifunctional hydrogel for passive solar-driven efficient water purification

Mei,

Jin,

Bai

et al. 2023

J. Mater. Chem. A

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“…As shown in Fig. 3a 1 -f 1 , the surface of all bers shows small wrinkles due to the shrinkage of molecular chains during the formation process of bers in a coagulation bath (Ding et al 2019). Previous studies have found that the small wrinkles on the surface of regenerated collagen bers are conducive to the adhesion and growth of rat tissue connective broblasts (Wang et al 2016).…”

Section: Sem Observation Of Bers Morphologymentioning

confidence: 89%

Effects of oxidized cellulose nanocrystals on the structure and mechanical properties of regenerated collagen fibers

Ding

Yue

et al. 2022

Cellulose

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The mechanical properties of regenerated collagen composite materials are of signi cant importance for promoting its diverse applications. However, the e cient strategy reported so far for enhancing the mechanical properties of regenerated collagen bers remains limited. Herein, the oxidized cellulose nanocrystals (oCNCs) were successfully prepared in aqueous media by oxidation of the hydroxyl groups on the surface of cellulose nanocrystals (CNCs) using ammonium persulfate (APS) as an oxidant, and collagen composite bers were prepared by introducing oCNCs into the collagen matrix via the dry-jet wet spinning technique. The morphology, structures and properties of prepared collagen composite bers were carefully investigated. These results indicated that oCNCs and CNCs can induce collagen micro bril orientation during the formation process of bers and protect the possibility of their interactions with collagen molecules. Compared with CNCs, oCNCs offered higher levels of enhancing e ciency and the as-prepared collagen/oCNCs composite bers exhibited extraordinary improvements in both the tensile strength and toughness with only a 0.05 wt% oCNCs loading. The reason for this improvement is that the hydroxyl groups and carboxyl groups of oCNCs can form stronger hydrogen bonds and electrostatic interactions with collagen molecules, resulting in the synergistic enhancement of the tensile strength, toughness and thermal stability of collagen composite bers. This work provides an e cient and facile method to achieve collagen composite bers with high mechanical properties for their broad applications.

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Effects of the aspect ratio of multi-walled carbon nanotubes on the structure and properties of regenerated collagen fibers

Cited by 20 publications

References 50 publications

Hierarchically Assembled Type I Collagen Fibres as Biomimetic Building Blocks of Biomedical Membranes

Hierarchically Assembled Type I Collagen Fibres as Biomimetic Building Blocks of Biomedical Membranes

A mimosa-inspired photothermal-responsive multifunctional hydrogel for passive solar-driven efficient water purification

Effects of oxidized cellulose nanocrystals on the structure and mechanical properties of regenerated collagen fibers

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