Effects of the aqueous extract of Bridelia ferruginea stem bark on carrageenan-induced oedema and granuloma tissue formation in rats and mice

Olajide, Olumayokun A.; Makinde, J. M.; Awe, S. O.

doi:10.1016/s0378-8741(99)00006-9

Cited by 136 publications

(83 citation statements)

References 8 publications

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“…The generation of prostaglandins which are prime mediators of inflammation and pain can be suppressed by dimethoxy flavones. The release of prostaglandins and many other mediators has been implicated in the development of oedema due to carrageenan administration (Olajide et al 1999). Thus the inhibition of COX may be considered as a main mechanism for the observed anti-inflammatory effect of dimethoxy flavones in the present study and anti-nociceptive effect reported earlier (Kamalakannan et al 2014).…”

Section: Anti-inflammatory Effect Of Dimethoxy Flavonessupporting

confidence: 69%

Anti-inflammatory effect of certain dimethoxy flavones

et al. 2015

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Section: Anti-inflammatory Effect Of Dimethoxy Flavonessupporting

confidence: 69%

Anti-inflammatory effect of certain dimethoxy flavones

et al. 2015

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“…The cotton pellet granuloma method is widely used to assess its efficacy against the proliferative phase of inflammation in which tissue degeneration and fibrosis occur [25]. Subcutaneous implantation of cotton pellets into animals results in the formation of granuloma at the site of the implant.…”

Section: Discussionmentioning

confidence: 99%

Modulation of Inflammatory Processes by Leaves Extract from Clusia nemorosa Both In Vitro and In Vivo Animal Models

et al. 2011

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The present study was carried out to investigate the anti-inflammatory effect of the hexane extract of the leaves from Clusia nemorosa G. Mey, called HECn, using carrageenan-induced mice pleurisy and cotton pellet-induced mice granuloma. Additionally, the ability of HECn to affect both neutrophil migration as viability was investigated by use of the Boyden chamber assay and flow cytometry, respectively. The HECn significantly inhibited exudation, total leukocytes and neutrophils influx, as well as TNFα levels in carrageenan-induced pleurisy. However, the extract not suppressed the granulomatous tissue formation in the cotton pellet-induced granuloma test. Experiments performed in vitro revealed that HECn on human neutrophils inhibited a dose-dependent manner the CXCL1-induced neutrophil chemotaxis. Furthermore, HECn also inhibited the chemoattraction of human neutrophils induced by formyl-methionyl-leucyl-phenylalanine (fMLP), leukotriene B4 (LTB4) and platelet activating factor (PAF) in a Boyden chamber. However, this same treatment not was able to induce apoptosis. The results obtained in this study showed that the extract from leaves of C. nemorosa possess a potent inhibitory activity in acute model of inflammation, being the effects mediated, in part, by inhibition of neutrophil responsiveness. These results indicate that C. nemorosa could be a good source for anti-inflammatory compounds.

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“…The increase in the weight of dried cotton pellets was taken as the measure of granuloma formation. The antiproliferative effects of test compounds were determined by comparing the results obtained in test groups with those in the control group 17 ( Table 1).…”

Section: Cotton Pellet-induced Granuloma Methodsmentioning

confidence: 99%