Effects of the aqueous and methylene chloride extracts of Bidens pilosa leaf on fructose-hypertensive rats

Dimo, Théophile; Azay, Jacqueline; Tan, Paul V.; Pellecuer, J.; Cros, Gérard; Bopelet, M.; Serrano, Jean Jacques

doi:10.1016/s0378-8741(01)00229-x

Cited by 62 publications

(66 citation statements)

References 24 publications

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“…Different Bidens pilosa leaf extracts were tested on various smooth muscles. Its hypotensive effect on hypertensive induced rats (Dimo et al, 1998;Dimo et al, 2001; Dimo et al, 2003) and, its relaxant effect was also showed on isolated rat vascular smooth muscle (Nguelefack et al, 2005). Its antisecretory and antiulcerogenic properties on various gastric ulcers models in rat showed that the methylene chloride extract is the most potent inhibitor of gastric mucosal lesions caused by HCl/ethanol, and that the extract does not possess anti-secretory potential, and tended to increase gastric acidity when gastric outflow is obstructed by ligature; a possible cytoprotective action mediated by the cytoprotective action of endogenous prostaglandins was also demonstrated (Tan et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

In vivo and in vitro effects of Bidens pilosa l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

Longo

Rakotonirina

Rakotonirina³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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Bidens pilosa L. is an Asteraceae growing in tropical zones, and traditionally utilized worldwide in herbal medicine. The present work is based on its traditional use during child birth as a labour facilitator. In vivo tests of acute toxicity showed a weak toxic effect for both extracts but the toxicity of the ethanol extract (LD 50 =6.15g/kg) was upper than that of the aqueous extract (LD 50 =12.30g/kg). The three-days uterotrophic assay on immature mice showed body weight gain followed by a concentration-dependent decrease up to 4mg/g and a concentration dependent uterine wet weight increase. The ethanol extract exhibited the higher body weight gain representing 22.8±0.7%, (P≤0.001), at the concentration of 500µg/g/day, while the aqueous extract was significantly more efficient on the uterine wet weight gain of 0.24±0.001% (P≤0.05), at the concentration of 1000µg/g/day. In vitro isometric contraction measurement of oestrogen-primed rat uterine strips showed a significant high aqueous extract-induced contractile effect from 0.03-1.97mg/ml: on the amplitude of contraction (EC 50 = 0.44±0.10mg/ml, P≤0.05), and on the rate (1.21±0.25mg/ml, P>0.05). Inspite of the higher effect of the aqueous extract on the tonus (57.23±23%), the ethanol extract showed a high effect (EC 50 = 0.34±0.09mg/ml, P≤0.05). The weak toxicity, the estrogenic-like and the oxytocic-like activities observed could explain the empirical use of Bidens pilosa leaf aqueous extract as an uterotonic preparation to enhance labour, probably due to the presence of biologically active compound(s) which act directly on the uterine muscle.

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Section: Introductionmentioning

confidence: 99%

In vivo and in vitro effects of Bidens pilosa l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

Longo

Rakotonirina

Rakotonirina³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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“…Recently, B. pilosa has been the subject of various laboratory studies due to its wide use in herbal medicine. Its antihypertensive activity against salt and fructose-induced hypertension was demonstrated (Dimo et al, 1999;2001). Also, in 1998, Dimo et al reported that the leaf aqueous extract possesses aortic smooth muscle relaxant activity.…”

Section: Introductionmentioning

confidence: 99%

“…Also, in 1998, Dimo et al reported that the leaf aqueous extract possesses aortic smooth muscle relaxant activity. A research group in our laboratory has demonstrated its gastric cytoprotective action against various experimental ulcer models in rats (Tan et al, 2001). Phytochemical studies of B. pilosa have revealed the presence of alkaloids, saponins, flavonoids, polyacetylenes and triterpenes (Hoffmann and Hölzl, 1988), phenylheptatriyne, linoleic acid and and exsanguinated by carotid artery section.…”

Section: Introductionmentioning

confidence: 99%

Relaxant effects of the neutral extract of the leaves ofBidens pilosa Linn on isolated rat vascular smooth muscle

et al. 2005

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The long-lasting antihypertensive effect of a neutral extract of Bidens pilosa has been suggested to be due to vasodilation. The present work was undertaken to assess this hypothesis. The vasorelaxant effect of a neutral extract (NBp) of the leaves of B. pilosa was evaluated in vitro on isolated rat aorta contracted with KCl or norepinephrine. NBp induced a concentration-dependent vasorelaxation of the rat aorta precontracted with KCl (60 mM) by 25%-105% at the respective concentrations of 0.25-1.5 mg/mL. The maximal concentration of 1.5 mg/mL provoked 88% relaxation of norepinephrine-induced contractions. There were no significant differences between the effects of the extract on the aorta strips with or without endothelium. In the presence of indomethacin or pyrilamine maleate, the relaxant response induced by the plant extract was significantly inhibited at the lower concentrations. The plant extract was able to reduce the aorta resting tone, inhibit the KCl-induced contractions (90% at 1.5 mg/mL) and the CaCl2-induced contractions by 95% at a concentration of 0.75 mg/mL. These results demonstrate the vasodilating properties of the neutral extract of Bidens pilosa and indicate that it may act as a calcium antagonist.

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“…Numerous drugs from plants have also been used in the treatment of hypertension. Solanum sisymbriifolium (Ibarrol et al, 1996), Spergularia purpurea (Jouad et al, 2001), Croton schiedeanus (Guerrero et al, 2001), Bidens pilosa (Dimo et al, 2001), Stephaniae tetrandrae (RAO, 2002), Trigonella Foenum-greacum (Balaraman et al, 2006) are some of the plants used in hypertension.…”

Section: Introductionmentioning

confidence: 99%

“…increased BP in rats (Juann et al, 1988;Bunnag et al, 1997;Dimo et al, 2001). Chronic fructose feeding leads to insulin resistance, glucose intolerance, hyperinsulinemia, hyperglycemia and hypertriglyceridemia in a relatively short time in normal rats (Zavaroni et al, 1980;Hwang et al, 1987;Erlich and Rosenthal, 1995).…”

mentioning

confidence: 99%

Effect of an herbal formulation on DOCA-salt and fructose induced models of hypertension in rats

Athare¹,

Mohan²,

Kasture³

2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe present study was carried out to investigate the antihypertensive effect of a folklore herbal formulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced and fructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) was administered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking water was replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic blood pressure (BP) was measured once every week during the treatment schedule. After completion of treatment schedule, BP and vascular reactivity to various agonists like Noradrenaline, Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats of both models. A cumulative concentration response curve of 5-HT was carried out in isolated rat fundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tend to suggest that HF possesses antihypertensive activity.

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Effects of the aqueous and methylene chloride extracts of Bidens pilosa leaf on fructose-hypertensive rats

Cited by 62 publications

References 24 publications

<i>In vivo</i> and <i>in vitro</i> effects of <i>Bidens pilosa</i> l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

<i>In vivo</i> and <i>in vitro</i> effects of <i>Bidens pilosa</i> l. (asteraceae) leaf aqueous and ethanol extracts on primed-oestrogenized rat uterine muscle.

Relaxant effects of the neutral extract of the leaves ofBidens pilosa Linn on isolated rat vascular smooth muscle

Effect of an herbal formulation on DOCA-salt and fructose induced models of hypertension in rats

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