Effects of the antidepressant paroxetine on migratory behaviour of meiobenthic nematodes: Computational and open experimental microcosm approach

Ishak, Sahar; Allouche, Mohamed; Harrath, Abdel Halim; Alwasel, Saleh; Beyrem, Hamouda; Pacioglu, Octavian; Badraoui, Riadh; Boufahja, Fehmi

doi:10.1016/j.marpolbul.2022.113558

Cited by 6 publications

(6 citation statements)

References 48 publications

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“…Comparing the results obtained from the current study with those of Ishak et al, [19], the differences spotted by the SIMPER analysis are not straightforward. In this work, the SIMPER analysis indicated a clearer effect of amitriptyline on the community of nematodes.…”

Section: What Is the Effect Of Contamination With Amitriptyline On Ne...contrasting

confidence: 55%

“…A laboratory experiment, comprising specially designed microcosms, was used (Figure 2). Each microcosm comprised 10 cm diameter polyvinyl chloride tubes, closed at both ends [19]. The main tube was separated in two equally sized compartments.…”

Section: Experiments Set-upmentioning

confidence: 99%

“…Currently, the toxic impact of these types of emergent pollutants on marine meiobenthos is not well documented, particularly on sediment-dwelling invertebrates such as free-living nematodes, polychaetes, copepods, and amphipods (Figure 1). The nematodes comprise the dominant meiobenthic group and have a long history of being reliably used as ecological indicators, due their small size (1-5 mm), high abundance and diversity, as well as easy laboratory maintenance [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…The amount of evidence supporting the migratory behaviour of meiobenthos following exposure to pollutants has mounted recently, due to the necessity of more realistic experimental devices where the natural behaviour, besides the standard toxicological end points, is also to be assessed [37,38]. Recently, the response of marine nematodes following exposure to the antidepressant paroxetine was tested in laboratory microcosms by Ishak et al [19]. The results obtained showed significant changes in nematofauna taxonomic composition, as well as the dominance of species with certain functional traits (i.e., type of feeding groups, tail and amphid shapes, body size) that are best adapted following the exposure to this antidepressant.…”

Section: Introductionmentioning

confidence: 99%

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The Antidepressants Amitriptyline and Paroxetine Induce Changes in the Structure and Functional Traits of Marine Nematodes

et al. 2022

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Increasing concentrations of the antidepressants amitriptyline and paroxetine were determined recently in marine habitats. However, their impact on marine biota is understudied, despite multiple undesirable effects they have on the environment. An important behavioral aspect that is increasingly measured following exposure to contaminants is the migration of fauna from contaminated areas. Hence, our aim was to better understand the migration pattern of marine meiobenthic fauna, but with a main focus on nematodes, following the exposure to both antidepressants, alone or in mixture. The experiment was carried out in microcosms, which comprised an uncontaminated upper and a lower contaminated compartment, where amitriptyline was added, alone or mixed with paroxetine, at concentrations of 0.4 and 40 µg L−1. The overall abundance of meiobenthic groups decreased significantly following exposure to amitriptyline in both compartments, a pattern augmented by the mixture with paroxetine. The migration of nematodes towards the upper compartments of microcosms was triggered by the level of contamination with antidepressants. As such, the species Terschellingia longicaudata showed no significant change in abundance, suggesting tolerance to both antidepressants. On the other hand, the abundances of nematode taxa Cyatholaimus prinzi, Calomicrolaimus sp., Calomicrolaimus honestus, Neochromadora sp., Chromadorina sp. and Chromadorina minor decreased significantly following the exposure to both antidepressants, even at low concentrations. At the end of the experiment, the dominant migratory nematodes belonged to deposit-feeders and omnivores-carnivores trophic guilds, with tail shapes of e/f types and body-sizes longer than 2 mm. Such functional traits increase their mobility in sediments and the chance to move away from contaminated habitats. Moreover, the sex ratio was imbalanced in the favor of males in contaminated lower compartments with mixtures of the lowest and highest concentrations of amitriptyline and paroxetine, suggesting that these drugs also affect the hormone system. In conclusion, the exposure to the antidepressants amitriptyline and paroxetine triggered important changes within nematode communities, as changes in taxonomic composition were a result of migration and survival of tolerant taxa, but equally acting on the hormone system and leading to unbalanced sex-ratio among the residents.

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Section: What Is the Effect Of Contamination With Amitriptyline On Ne...contrasting

confidence: 55%

Section: Experiments Set-upmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Antidepressants Amitriptyline and Paroxetine Induce Changes in the Structure and Functional Traits of Marine Nematodes

et al. 2022

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“…The negative impact on the health of clams, as reported by disruption in the assessed biomarkers, MDA levels, and decreased AChE activity might be the consequence of the bioavailability and toxicokinetic properties of iron ore. Such results might include interactions with the cytochrome P450 (Cyp) isoforms such as Cyp1A2, Cyp3A4, and CypC19… ( Ishak et al, 2022 , Badraoui et al, 2023 ). Interactions with Cyp are commonly assessed in toxicological approaches ( Badraoui et al, 2023 , Hedfi et al, 2022 ) as they are usually associated with mild to severe toxicological outcomes ( Allouche et al, 2022 , Hedfi et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Are iron ore microparticles toxic for the European clam Ruditapes decussatus? Response elements from biomarker activities and in silico modeling

Aillal,

Khazri,

Al-Hoshani

et al. 2023

Saudi Journal of Biological Sciences

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Ecotoxicity of chrysene and phenanthrene on meiobenthic nematodes with a case study of Terschellingia longicaudata: Taxonomics, toxicokinetics, and molecular interactions modelling

Badraoui

Allouche

Ouaer

et al. 2023

Environmental Pollution

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Effects of the antidepressant paroxetine on migratory behaviour of meiobenthic nematodes: Computational and open experimental microcosm approach

Cited by 6 publications

References 48 publications

The Antidepressants Amitriptyline and Paroxetine Induce Changes in the Structure and Functional Traits of Marine Nematodes

The Antidepressants Amitriptyline and Paroxetine Induce Changes in the Structure and Functional Traits of Marine Nematodes

Are iron ore microparticles toxic for the European clam Ruditapes decussatus? Response elements from biomarker activities and in silico modeling

Ecotoxicity of chrysene and phenanthrene on meiobenthic nematodes with a case study of Terschellingia longicaudata: Taxonomics, toxicokinetics, and molecular interactions modelling

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