Effects of the Angiotensin-converting Enzyme Inhibitor Enalapril on Sympathetic Neuronal Function and .BETA.-adrenergic Desensitization in Heart Failure after Myocardial Infarction in Rats.

Igawa, Akihiko; Nozawa, Takashi; Yoshida, Naohiro; Fujii, Naohiko; Kato, Bunichi; Inoue, Minoru; Tazawa, Shusaku; Yamada, Yoshihisa; Asanoi, Hidetsugu; Inoue, Hiroshi

doi:10.1536/jhj.43.675

Cited by 5 publications

(1 citation statement)

References 45 publications

(61 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Previous studies have suggested that ACEI, angiotensin receptor blocker, -blockers and spironolactone can improve the parameters of cardiac 123 I-MIBG scintigraphy and decrease plasma levels of BNP in patients with CHF. 16,23,[25][26][27][28][29][30][31][32][33][34][35][36] Both parameters of cardiac 123 I-MIBG scintigraphy and plasma BNP levels are useful surrogate markers for the management of CHF patients. We have reported that repeated measurements of cardiac 123 I-MIBG imaging parameters before and after 6-month optimized treatments are useful for predicting the prognoses of patients with moderate to severe CHF.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure Comparison With Enalapril

Tsutamoto

Tanaka

Nishiyama

et al. 2008

Circ J

View full text Add to dashboard Cite

BackgroundIn patients with chronic heart failure (CHF), it remains unclear whether perindopril is more cardioprotective than enalapril. Methods and Results Forty-five stable CHF outpatients undergoing conventional therapy including enalapril therapy were randomized to 2 groups [group I (n=24): continuous enalapril treatment; group II (n=21): enalapril was changed to perindopril]. Cardiac sympathetic nerve activity was evaluated using cardiac 123 I-metaiodobenzylguanidine (MIBG) scintigraphy, hemodynamic parameters and neurohumoral factors before and 6 months after treatment. There was no difference in baseline characteristics between the 2 groups. In group I, there were no changes in MIBG parameters, left ventricular ejection fraction (LVEF) or plasma level of brain natriuretic peptide (BNP). In contrast, in group II the delayed heart/mediastinum count ratio was significantly increased (2.0±0.07 vs 2.15±0.07, p=0.013) and the washout rate was significantly decreased (33.0±1.4 vs 30.5±1.2, p=0.030) after 6 months compared with the baseline value. In addition, LVEF was significantly increased and the plasma BNP level was significantly decreased. Conclusion These findings suggest that for the treatment of CHF, perindopril is superior to enalapril with respect of cardiac sympathetic nerve activity and BNP. (Circ J 2008; 72: 740 -746)

show abstract

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure Comparison With Enalapril

Tsutamoto

Tanaka

Nishiyama

et al. 2008

Circ J

View full text Add to dashboard Cite

show abstract

How do we establish cardiac sympathetic nervous system imaging with 123I-mIBG in clinical practice? Perspectives and lessons from Japan and the US

Travin

Matsunari

Thomas

et al. 2019

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Cardiac denervation is associated with progressive left ventricular (LV) dysfunction, ventricular arrhythmias, and sudden cardiac death (SCD) in heart failure (HF). In this regard, it is important to evaluate cardiac-specific sympathetic nervous system (SNS) function. The radiotracer Iodine-123 meta-iodobenzylguanidine (I-mIBG) can noninvasively evaluate pre-synaptic SNS function. Recent multicenter trials have shown I-mIBG to have strong predictive value for fatal arrhythmias and cardiac death in HF.I-mIBG was initially developed in the USA in the 1970s. In 1992, the Japanese Ministry of Health and Labour approved I-mIBG for the assessment of cardiac function. Following approval, the Japanese nuclear cardiology community developedI-mIBG imaging services in various medical centers. Japanese groups have been trying to establish the clinical utility of I-mIBG and standardize parameters for data acquisition and image analysis. The US Food and Drug Administration (FDA) has approved clinical use ofI-mIBG for cardiac and non-cardiac imaging. However, clinical use of I-mIBG in the US has been very limited. The number ofI-mIBG studies in Japan has also been limited. There are similarities and differences between the two countries. To establish the clinical utility of I-mIBG in both countries, it is important to characterize the situations ofI-mIBG in each.

show abstract

Changes in -adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin–angiotensin system

et al. 2004

View full text Add to dashboard Cite

Earlier studies have revealed an improvement of cardiac function in animals with congestive heart failure (CHF) due to myocardial infarction (MI) by treatment with angiotensin converting enzyme (ACE) inhibitors. Since heart failure is also associated with attenuated responses to catecholamines, we examined the effects of imidapril, an ACE inhibitor, on the beta-adrenoceptor (beta-AR) signal transduction in the failing heart. Heart failure in rats was induced by occluding the coronary artery, and 3 weeks later the animals were treated with g/(kg x day) (orally) imidapril for 4 weeks. The animals were assessed for their left ventricular function and inotropic responses to isoproterenol. Cardiomyocytes and crude membranes were isolated from the non-ischemic viable left ventricle and examined for the intracellular concentration of Ca2+ [Ca2+]i and beta-ARs as well as adenylyl cyclase (AC) activity, respectively. Animals with heart failure exhibited depressions in ventricular function and positive inotropic response to isoproterenol as well as isoproterenol-induced increase in [Ca2+]i in cardiomyocytes; these changes were attenuated by imidapril treatment. Both beta1-AR receptor density and isoproterenol-stimulated AC activity were decreased in the failing heart and these alterations were prevented by imidapril treatment. Alterations in cardiac function, positive inotropic effect of isoproterenol, beta1-AR density and isoproterenol-stimulated AC activity in the failing heart were also attenuated by treatment with another ACE inhibitor, enalapril and an angiotensin II receptor antagonist, losartan. The results indicate that imidapril not only attenuates cardiac dysfunction but also prevents changes in beta-AR signal transduction in CHF due to MI. These beneficial effects are similar to those of enalapril or losartan and thus appear to be due to blockade of the renin-angiotensin system.

show abstract

Effects of the Angiotensin-converting Enzyme Inhibitor Enalapril on Sympathetic Neuronal Function and .BETA.-adrenergic Desensitization in Heart Failure after Myocardial Infarction in Rats.

Cited by 5 publications

References 45 publications

Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure Comparison With Enalapril

Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure Comparison With Enalapril

How do we establish cardiac sympathetic nervous system imaging with 123I-mIBG in clinical practice? Perspectives and lessons from Japan and the US

Changes in -adrenoceptors in heart failure due to myocardial infarction are attenuated by blockade of renin–angiotensin system

Contact Info

Product

Resources

About