Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility

Barrett, A. John; Murray, Richard D.; Christley, Rob; Dobson, H.; Smith, Robert F.

doi:10.1136/vr.165.21.623

Cited by 15 publications

(7 citation statements)

References 30 publications

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“…Reproductive tract disease may substantially impair performance [15, 23, 46]. Delay in uterine involution significantly affects fertility and reproductive performance [5, 9, 18, 39, 45]. Treatments that enhance or accelerate uterine involution, or reduce the incidence of uterine disease may increase reproductive efficiency.…”

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confidence: 99%

“…Treatments that enhance or accelerate uterine involution, or reduce the incidence of uterine disease may increase reproductive efficiency. It has been suggested that ecbolic drugs like oxytocin and prostaglandin F2α (PGF2α) could be used as preventative treatments to enhance uterine involution by promoting uterine contraction and clearance of debris and fluid, and potentially improve reproductive performance [2, 5]. The normal bovine uterus shows a progressive decrease in contractility over time postpartum [3].…”

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confidence: 99%

“…A single intramuscular injection of oxytocin or carbetocin (long acting analogue of oxytocin) did not prolong the uterotonic effect in postpartum dairy cows [2]. Another study indicated no difference in the incidence of endometritis or median interval from calving to pregnancy when a single injection of either oxytocin or carbetocin was administered within 6 hr of calving in dairy cows [5]. A clinical trial conducted in crossbred Zebu cows where two injections of oxytocin where administered intramuscularly immediately after calving and 6 hr later respectively did not improve reproductive performance [34].…”

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The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows

Stephen

Johnson

LeBlanc

et al. 2019

The Journal of Veterinary Medical Science

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Postpartum uterine disease due to poor uterine involution continues to be a significant factor that contributes to poor reproductive efficiency in dairy cattle. Therapy that increases the frequency, duration and strength of uterine contractions in the postpartum period might enhance uterine involution, resulting in improved reproductive performance. The objective of this clinical trial was to study the effect of two uterine ecbolic therapies, oxytocin and prostaglandinF2α on uterine involution, postpartum endometritis, and reproductive performance. A randomized double-blinded clinical trial was conducted in 118 dairy cows from two research herds that had normal parturition and expulsion of the fetal membranes. Within 24 hr after calving, cows were randomly assigned to receive intramuscular injections twice a day of 50 IU of oxytocin, or 25 mg of dinoprost (PGF2α) or saline (control) for 7 days. Cows were monitored from day 3 to day 63 ± 3 days postpartum by transrectal palpation of the uterus, vaginoscopy, Metricheck® examination and by endometrial cytology. Blood samples were collected for measurement of progesterone in weeks 3 (21 ± 3 days), 5 (35 ± 3 days), 7 (49 ± 3 days), and 9 (63 ± 3 days) postpartum. Herd breeding records were obtained to determine reproductive performance in all cows. Neither oxytocin nor prostaglandin F2α therapy during the first week postpartum had any significant effect on the rate of uterine involution, prevalence of endometritis or reproductive performance, compared to untreated controls. Ecbolic drugs, as used here, are not recommended for use in clinical practice to improve involution or reproductive tract health in normal cows.

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The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows

Stephen

Johnson

LeBlanc

et al. 2019

The Journal of Veterinary Medical Science

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“…Red and blue symbols indicate data from the UK and the present study, respectively. Each symbol represents data from different studies in different years; the hatched line depicts a linear trend‐line for all data within each panel (Muller and Owens 1974, Philipsson 1976, Cobo‐Abreu and others 1979, Sandals and others 1979, Shanks and others 1979, Zamet and others 1979, Erb and others 1981a, Erb and others 1981b, Dohoo and Martin 1984, Erb and others 1985, Etherington and others 1985, Halpern and others 1985, Martin and others 1986, Hamudikuwanda and others 1987, Francos and Mayer 1988, Holt and others 1989, Lee and others 1989, Oltenacu and others 1990, Barkema and others 1992, Van Werven and others 1992, Harman and others 1996, Dematawena and Berger 1997, Domecq and others 1997, Kaneko and others 1997, Markusfeld and others 1997, Emanuelson and Oltenacu 1998, Suriyasathaporn and others 1998, Leblanc and others 2002, Esslemont and Kossaibati 2002, Barrett and others 2009 )…”

Section: Discussionmentioning

confidence: 99%

Effects of periparturient events on subsequent culling and fertility in eight UK dairy herds

Hayes¹,

Christley

Dobson

2012

Veterinary Record

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The occurrence of five periparturient events and their effects on subsequent culling and fertility was recorded in eight herds in the UK. Combining data from all 2105 calvings, the proportion affected by assisted calving, dead calf, retained fetal membranes (RFM), milk fever or twins was 5.9, 8.2, 5.3, 5.0 or 3.3 per cent, respectively. Compared with unaffected herdmates, cows with an assisted calving or a dead calf had higher early (but not late) culling rates, (assisted calving: 8.8 per cent being culled before 100 days after calving compared with 5.7 per cent; P=0.05; dead calf: 12.2 per cent culled compared with 5.3 per cent; P=0.001). Compared with unaffected animals, cows with milk fever were four times more likely to be culled before 100 days after calving (16.2 per cent compared with 5.3 per cent; P=0.001), whereas those with RFM were twice as likely to be culled between 100 and 200 days (14.3 per cent compared with 7.6 per cent; P=0.003), and both groups were twice as likely to not be pregnant by 200 days. Cows with RFM or milk fever also had markedly reduced subsequent fertility: both conditions extended calving to pregnancy intervals (by 20 days; P=0.001, or by 13 days; P=0.03, respectively), lowered 100-day in-calf rates (by 24.5 per cent; P=0.001, or by 17.8 per cent; P=0.008, respectively) and lowered 200-day in-calf rates (by 20 per cent; P=0.001, or by 15 per cent; P=0.002, respectively). The birth of twins had no effect on subsequent culling or fertility.

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“…Early postpartum dairy cows treated with carbetocin had a lower occurrence of RFM (Kudlac and Zamecnik 1984). However, Barrett et al (2009) concluded that routine administration of a single injection of either oxytocin or carbetocin after calving had no significant benefit. (1989) reported the positive effects of PGF 2α on selected reproductive parameters in cattle.…”

Section: Discussionmentioning

confidence: 99%

Post-calving administration of uterine stimulants does not improve reproductive performance in dairy cows

Holickova¹,

Doležel²,

Čech³

2015

Vet. Med. - Czech

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ABSTRACT:The aim of this study was to evaluate the effects of administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on the occurrence of clinical endometritis and subsequent reproductive performance in dairy cows. The cows, without retained foetal membranes, were assigned to one of three groups. No treatment was performed in the control group (Group C, n = 229). However, intramuscular administrations of oxytocin (30 IU) on Days 1 and 2 post partum, in combination with dinoprost (25 mg, Group D, n = 123) or ergometrin (15 mg, Group E, n = 130) administered on Day 7 post partum, were performed in experimental groups. Vaginal discharge score (VDS, 1-5), uterine content score (UCS, 1-3) on Day14 to 21 post partum, number of treatment interventions (TI), proportion of non-treated cows (NT) because of endometritis, calving to first insemination interval (CI), first insemination conception rate (CR), and proportion of pregnant cows by Day 150 post partum (PC), were compared among groups. There was no significant difference among groups for any parameter. Average values were 2.08, 2.24 and 2.06 (VDS); 1.49, 1.51 and 1.45 (UCS); 0.86, 0.93 and 0.74 (TI); 59.4, 54.2 and 54.7% (NT); 73.9 ± 15.2, 75.4 ± 17 and 74.2 ± 17 days (CI); 41.4, 38.9 and 44.3% (CR); and 75.4, 77.7 and 80.5% (PC) for Groups C, D and E, respectively. There was no significant benefit of preventive administration of oxytocin, in combination with dinoprost or ergometrin, after parturition on reproductive performance in dairy cows.Keywords: cow; endometritis; oxytocin; dinoprost; ergometrin; reproductive parameters Abbreviations CI = calving to the first insemination interval, CR = first insemination conception rate, NT = non-treated cows, PC = proportion of pregnant cows by day 150 post partum, TI = treatment interventions, TMR = total mixed ration, UCS = uterine content score, VDS = vaginal discharge score

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Effects of the administration of oxytocin or carbetocin to dairy cows at parturition on their subsequent fertility

Cited by 15 publications

References 30 publications

The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows

The impact of ecbolic therapy in the early postpartum period on uterine involution and reproductive health in dairy cows

Effects of periparturient events on subsequent culling and fertility in eight UK dairy herds

Post-calving administration of uterine stimulants does not improve reproductive performance in dairy cows

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