Effects of the administration of coca alkaloids on the primary immune responses of mice: Interaction with Δ9-tetrahydrocannabinol and ethanol

Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense

“…Cuscohygrine was found to inhibit the delayed type hypersensitivity response to 2,4-dinitrofluorobenzene in mice; it produced 24% inhibition at daily doses of 60 mg/kg (Watson et al, 1983). Mice dosed with 60 mg/kg cuscohygrine had suppressed plaque forming cell/lo6 spleen cell responses (Watson et al, 1983).…”

“…At daily doses of 60 mg/kg c~namoylcoc~e orally, mice exhibited normal immune responses (Watson et al, 1983). Mice dosed with 60 mg/kg cinnamoylcoCaine had suppressed plaque forming cell/lo6 spleen cell responses (Watson et al, 1983). The plaque forming cell/spleen responses were significantly suppressed in mice treated with cinnamoylcocaine (Watson et al, 1983).…”

“…At a concentration of 10V3 M, benzoyleegonine produced approximately 40% inhibition of verat~dine-st~ulat~ 22Na+ uptake in an assay with rat brain membrane homogenate (Matthews and Collins, 1983). At daily doses of 60 mg/kg benzoylecgonine orally, mice exhibited normal immune responses (Watson et al, 1983). Mice dosed with 60 mg/kg benzoylecgonine had suppressed plaque forming cell/lo6 spleen cell responses (Watson et al, 1983).…”

“…At daily doses of 60 mg/kg benzoylecgonine orally, mice exhibited normal immune responses (Watson et al, 1983). Mice dosed with 60 mg/kg benzoylecgonine had suppressed plaque forming cell/lo6 spleen cell responses (Watson et al, 1983). Benzoylecgonine did not affect the formation and release of [ "Cldopamine in synaptosomalmitochondrial preparations from the caudate nucleus of rat brain (Bagchi and Reilly, 1983).…”

“…At daily doses of 60 mg/kg methylecgonine orally, mice exhibited normal immune responses (Watson et al, 1983). Mice dosed with 60 mg/kg methylecgonine did not have suppressed plaque forming cell/lo6 spleen cell responses (Watson et al, 1983).…”