Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats

Gotoh, Leo; Kawanami, Noriko; Nakahara, Tsutomu; Hondo, Hisao; Motomura, Kinsi; Ohta, Eiko; Kanchiku, Izumi; Kuroki, Tetsuo; Hirano, Minoru; Uchimura, Hideyuki

doi:10.1016/s0169-328x(02)00136-5

Cited by 19 publications

(11 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is supported by previous studies (Habara et al 2001), but this finding is not consistent across all studies using NMDA antagonists (Gao et al 1998 (NAc overall); De Leonibus et al 2002 (NAc core)). We also find that PCP induces c-Fos-IR in the CA1, which has not previously been found in studies with similar or lower PCP doses (Näkki et al 1996;Gotoh et al 2002Santana et al 2011, but is in line with previous studies using stronger PCP doses or other NMDA antagonists (Näkki et al 1996;Väisänen et al 2004;Imre et al 2006) supporting this region to be involved in mechanisms underlying NMDA hypofunction.…”

Section: Pcp-induced C-fos-ir In the Pfc And MDsupporting

confidence: 92%

“…It is wellestablished that acute systemic administration of PCP increases levels of the immediate early gene (IEG) c-Fos in several areas including PFC, hippocampus, nucleus accumbens (NAc) and thalamic nuclei in rodents (Näkki et al 1996;Sato et al 1997;Griffiths et al 1999;Habara et al 2001;Gotoh et al 2002;Kargieman et al 2007;Kargieman et al 2008;Kalinichev et al 2008;Santana et al 2011;Castañe et al 2015). It has been reported that PCP-induced c-Fos mRNA occurs in GAD67-neurons in the hippocampus, amygdala, as well as somatosensory and retrosplenial cortex (Santana et al 2011).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

et al. 2016

View full text Add to dashboard Cite

Dysfunction of N-Methyl-D-aspartate receptors (NMDARS) is believed to underlie some of the symptoms in schizophrenia, and non-competitive NMDAR antagonists (including phencyclidine (PCP)) are widely used as pharmacological schizophrenia models. Furthermore, mounting evidence suggests that impaired γ-aminobutyric acid (GABA) neurotransmission contributes to the cognitive deficits in schizophrenia. Thus alterations in GABAergic interneurons have been observed in schizophrenia patients and animal models. Acute systemic administration of PCP increases levels of c-Fos in several cortical and subcortical areas, but whether such induction occurs in specific populations of GABAergic interneuron subtypes still remains to be established. Overall, our data indicate that PCP activates a wide range of cortical and subcortical brain regions and that a substantial part of this activation is present in GABAergic interneurons in certain regions. This suggests that the psychotomimetic effect of PCP may be mediated via GABAergic interneurons.

show abstract

Section: Pcp-induced C-fos-ir In the Pfc And MDsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The similar distribution of mGlu 2 and adenosine A 1 receptors throughout the limbic forebrain probably is an important underpinning to similar effects of activating these receptors across a wide range of neuropsychiatric preclinical models (Bauer et al, 2003;Richards et al, 2005). Hallucinogen-induced head shakes and hallucinogen/ (5S,10R)-(ϩ)-5-methyl-10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5,10-imine (MK-801)-induced immediate early gene expression are modulated by mGlu 2 or adenosine A 1 receptors in the PFC or on thalamocortical pathways (Scruggs et al, 2000;Gotoh et al, 2002;Pei et al, 2004;Benneyworth et al, 2007;Marek, 2009;Wischhof and Koch, 2012). Although adenosine A 1 receptors are located at both postsynaptic and presynaptic sites, these receptors are known to play a prominent role as heteroreceptors, decreasing excitatory amino acid release, similar to the mGlu 2 receptor role as an autoreceptor.…”

Section: Introductionmentioning

confidence: 99%

Activation of Adenosine₁ Receptors Induces Antidepressant-Like, Anti-Impulsive Effects on Differential Reinforcement of Low-Rate 72-s Behavior in Rats

Marek

2012

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Stress and psychiatric illness have been associated with a dysregulation of glutamatergic neurotransmission. Recently, positive allosteric modulators (PAMs) of the metabotropic glutamate 2 (mGlu 2 ) receptor have been found to exert antidepressant-like activity in rats performing under a differential reinforcement of low rate (DRL) 72-s schedule. An autoreceptor role at glutamatergic synapses is the most salient physiological role played by the mGlu 2 receptor. Adenosine A 1 receptors play a heteroreceptor role at many of the same forebrain synapses where mGlu 2 autoreceptors are found. Agonists and/or PAMs of mGlu 2 receptors act similarly to adenosine A 1 receptor agonists with respect to a wide range of electrophysiological, biochemical, and behavioral responses mediated by limbic circuitry thought to play a role in the pathophysiology of neuropsychiatric disease and to mediate therapeutic drug effects. Therefore, the role of adenosine A 1 receptor activation on rat DRL 72-s behavior was explored to provide preclinical evidence consistent or inconsistent with potential antidepressant effects. The adenosine A 1 receptor agonist N 6 -cyclohexyladenosine (CHA) increased the reinforcement rate, decreased the response rate, and induced a rightward shift in inter-response time distributions in a dose-dependent fashion similar to most known antidepressant drugs. The adenosine A 1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX) blocked these antidepressant-like effects. These novel observations with CHA and DPCPX suggest that activation of adenosine A 1 receptors could contribute to antidepressant effects, in addition to previous preclinical reports of anxiolytic and antipsychotic effects. By implication, targeting a dysregulated glutamatergic system may be an important principle in discovering novel antidepressant agents that may also possess anti-impulsive activity.

show abstract

“…The other two groups were subcutaneously injected with PCP (5.0 mg/kg, sc), and were sacrificed 1 and 4 hr postinjection, respectively. The dose of PCP was selected based on previous demonstrations that an acute subanesthetic dose of PCP (5.0 mg/kg) can induce changes in rat behavior, cognition, and gene expression in the brain [N€ akki et al, 1996;Jin et al, 1997;Cochran et al, 2002;Gotoh et al, 2002].The brains were removed immediately after the sacrifice. Serial slices of 300 mm were made from five brain regions, medial prefrontal cortex (mPFC), posterior cingulate cortex (PCC), hippocampus (HIP), nucleus accumbens (NAC), and striatum (STR) in a cryostat at À12 C using a microknife as previously described [Nakahara et al, 1990;Gotoh et al, 2002].…”

mentioning

confidence: 99%

“…The dose of PCP was selected based on previous demonstrations that an acute subanesthetic dose of PCP (5.0 mg/kg) can induce changes in rat behavior, cognition, and gene expression in the brain [N€ akki et al, 1996;Jin et al, 1997;Cochran et al, 2002;Gotoh et al, 2002].…”

mentioning

confidence: 99%

Positive association of Phencyclidine‐responsive genes, PDE4A and PLAT, with schizophrenia

Deng

Takaki

Wang

et al. 2011

American J of Med Genetics Pt B

Self Cite

View full text Add to dashboard Cite

As schizophrenia-like symptoms are produced by administration of phencyclidine (PCP), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, PCP-responsive genes could be involved in the pathophysiology of schizophrenia. We injected PCP to Wistar rats and isolated five different parts of the brain in 1 and 4 hr after the injection. We analyzed the gene expression induced by the PCP treatment of these tissues using the AGILENT rat cDNA microarray system. We observed changes in expression level in 90 genes and 21 ESTs after the treatment. Out of the 10 genes showing >2-fold expressional change evaluated by qRT-PCR, we selected 7 genes as subjects for the locus-wide association study to identify susceptibility genes for schizophrenia in the Japanese population. In haplotype analysis, significant associations were detected in combinations of two SNPs of BTG2 (P = 1.4 × 10(-6) ), PDE4A (P = 1.4 × 10(-6) ), and PLAT (P = 1 × 10(-3) ), after false discovery rate (FDR) correction. Additionally, we not only successfully replicated the haplotype associations in PDE4A (P = 6.8 × 10(-12) ) and PLAT (P = 0.015), but also detected single-point associations of one SNP in PDE4A (P = 0.0068) and two SNPs in PLAT (P = 0.0260 and 0.0104) in another larger sample set consisting of 2,224 cases and 2,250 controls. These results indicate that PDE4A and PLAT may be susceptibility genes for schizophrenia in the Japanese population.

show abstract

Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats

Cited by 19 publications

References 53 publications

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Activation of Adenosine₁ Receptors Induces Antidepressant-Like, Anti-Impulsive Effects on Differential Reinforcement of Low-Rate 72-s Behavior in Rats

Positive association of Phencyclidine‐responsive genes, PDE4A and PLAT, with schizophrenia

Contact Info

Product

Resources

About

Effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine on phencyclidine-induced behavior and expression of the immediate-early genes in the discrete brain regions of rats

Cited by 19 publications

References 53 publications

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Acute phencyclidine administration induces c-Fos-immunoreactivity in interneurons in cortical and subcortical regions

Activation of Adenosine1 Receptors Induces Antidepressant-Like, Anti-Impulsive Effects on Differential Reinforcement of Low-Rate 72-s Behavior in Rats

Positive association of Phencyclidine‐responsive genes, PDE4A and PLAT, with schizophrenia

Contact Info

Product

Resources

About

Activation of Adenosine₁ Receptors Induces Antidepressant-Like, Anti-Impulsive Effects on Differential Reinforcement of Low-Rate 72-s Behavior in Rats