Effects of the addition of low-dose ketamine to propofol-fentanyl anaesthesia during diagnostic gynaecological laparoscopy

Atashkhoyi, Simin; Negargar, Sohrab; Hatami-Marandi, Pouya

doi:10.1016/j.ejogrb.2013.06.026

Cited by 18 publications

(16 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean duration of analgesia observed in their study was 165 min for a mean duration of surgery of 45 min. [18] In our study with intermittent low-dose ketamine, the average duration of analgesia was found to be 480 min for surgeries of mean duration 77 min, which is significantly higher than above studies. This reemphasizes that preoperative as well as intraoperative use of ketamine is associated with better and longer analgesic effect.…”

Section: Discussioncontrasting

confidence: 57%

Efficacy of low-dose ketamine as sole analgesic agent in maintaining analgesia and intraoperative hemodynamics during laparoscopic gynecological surgeries

et al. 2017

View full text Add to dashboard Cite

Background:Ketamine, in low doses, is known to possess intense analgesic properties. The available literature shows wide variation regarding the time and dose of administration of ketamine during surgery.Aim:The aim of this study was to evaluate the effect of intraoperative administration of ketamine when used as sole analgesic in low doses, on hemodynamics and postoperative analgesia in patients undergoing laparoscopic gynecological surgery and compared on the basis of duration of surgery.Settings and Design:This prospective, observational study was conducted from July to December 2015, over a period of 6 months in a tertiary care medical college and hospital.Materials and Methods:Seventy patients between 23 and 55 years planned for laparoscopic gynecological surgery were recruited. Ketamine was given in a dose of 0.5 mg/kg preoperatively and then repeated every ½ hourly in a dose of 0.25 mg/kg throughout the surgery. Hemodynamic parameters, time to the first rescue analgesia and complications were recorded for the first 8 h. Statistical evaluation was done and result expressed as percentage. Paired t-test was employed for the comparison of numerical variables within the group.Results:Seventy percent of the patients did not require any postoperative rescue analgesia during the first 8 h after surgery. None of the patients complained of pain immediately after extubation, and 16% of the patients had minor postoperative complications. The intraoperative hemodynamic profile was significantly altered. Duration of surgery and dose of ketamine required did not affect the duration of analgesia.Conclusion:Ketamine in low dose proved to be an efficacious analgesic even in the long duration laparoscopic gynecological surgeries. It stabilizes intraoperative hemodynamics thereby reducing the requirement of other anesthetic and antihypertensive agents.

show abstract

Section: Discussioncontrasting

confidence: 57%

Efficacy of low-dose ketamine as sole analgesic agent in maintaining analgesia and intraoperative hemodynamics during laparoscopic gynecological surgeries

et al. 2017

View full text Add to dashboard Cite

show abstract

“…[ 44 45 ] It is used for sedation or general anesthesia for pediatric procedures like cardiac catheterization, radiation therapy, radiological studies such as magnetic resonance imaging, dressing changes, and dental work. [ 1 3 46 ] Ketamine in low doses in combination with low doses of propofol provides effective and safe sedo-analgesia in pediatric emergency short surgical procedures and in adults undergoing colonoscopy and short gynecological procedures[ 47 48 49 ] Sedation and analgesia in the critical care unit: Ketamine used for patients in a critical care unit provides combined sedation and analgesia and has favorable effects on hemodynamics and can treat persistent bronchospasm. [ 1 2 ] Continuous IV infusion of ketofol provides adequate and safe short term sedation(<24 h) for critically ill patients in ICU.…”

Section: Current Clinical Applications Of Ketaminementioning

confidence: 99%

Section: Current Clinical Applications Of Ketaminementioning

confidence: 99%

Ketamine: Current applications in anesthesia, pain, and critical care

2014

View full text Add to dashboard Cite

Ketamine was introduced commercially in 1970 with the manufacturer's description as a “rapidly acting, nonbarbiturate general anesthetic” and a suggestion that it would be useful for short procedures. With the help of its old unique pharmacological properties and newly found beneficial clinical properties, ketamine has survived the strong winds of time, and it currently has a wide variety of clinical applications. It's newly found neuroprotective, antiinflammatory and antitumor effects, and the finding of the usefulness of low dose ketamine regimens have helped to widen the clinical application profile of ketamine. The present article attempts to review the current useful applications of ketamine in anesthesia, pain and critical care. It is based on scientific evidence gathered from textbooks, journals, and electronic databases.

show abstract

“…Neither clonidine nor ketamine alone reduced the post-operative PCA morphine requirements in patients undergoing spine surgery [39] . Atashkhoyi [40] concluded that the use of low-dose ketamine with propofol-fentanyl anesthesia in patients undergoing diagnostic laparoscopy for gynecological procedures was associated with less pain during propofol injection, a lower incidence of hemodynamic changes, lower total propofol requirements and improved post-operative analgesia. However, not all trials have shown such promising results for the use of ketamine.…”

Section: Wwwchinapharcom Gao M Et Almentioning

confidence: 99%

Ketamine use in current clinical practice

2016

View full text Add to dashboard Cite

After nearly half a century on the market, ketamine still occupies a unique corner in the medical armamentarium of anesthesiologists or clinicians treating pain. Over the last two decades, much research has been conducted highlighting the drug's mechanisms of action, specifically those of its enantiomers. Nowadays, ketamine is also being utilized for pediatric pain control in emergency department, with its anti-hyperalgesic and anti-inflammatory effects being revealed in acute and chronic pain management. Recently, new insights have been gained on ketamine's potential anti-depressive and antisuicidal effects. This article provides an overview of the drug's pharmacokinetics and pharmacodynamics while also discussing the potential benefits and risks of ketamine administration in various clinical settings.

show abstract

Effects of the addition of low-dose ketamine to propofol-fentanyl anaesthesia during diagnostic gynaecological laparoscopy

Cited by 18 publications

References 18 publications

Efficacy of low-dose ketamine as sole analgesic agent in maintaining analgesia and intraoperative hemodynamics during laparoscopic gynecological surgeries

Efficacy of low-dose ketamine as sole analgesic agent in maintaining analgesia and intraoperative hemodynamics during laparoscopic gynecological surgeries

Ketamine: Current applications in anesthesia, pain, and critical care

Ketamine use in current clinical practice

Contact Info

Product

Resources

About