Effects of the Actindia chinensis on Loperamide-induced Constipation in Rat

Abstract

-Loperamide-induced constipation reduced gastric emptying, small-intestinal and colonic motility, and these effects were prevented by Actindia chinensis (Gold Kiwi Fruit, GKF). In this study, the effects of Actindia chinensis on constipated male Sprague-Dawley rats induced by loperamide(2 mg/kg, s.c.,5 days) were investigated. Rats were randomly assigned to the normal control rats(regular diet), constipated rats(regular diet plus loperamide), constipated rats treated with 2.5% GKF(regular diet supplemented with 2.5% GKF plus loperamide), constipated rats treated with 5% GKF (regular diet supplemented with 5% GKF plus loperamide). There was less fecal excretion and lower fecal water content in loperamide-treated rats than in control rats. Oral administration of GKF blocked the decrease of fecal excretion and fecal water content in the loperamide-treated rats. Mucus production of crypt cell and mucus contents at fecal and mucosa surface were reduced by loperamide-treated rat. But colonic crypt cell contained increased mucin in the GKF treated group and mucus layer stained with alcian blue was significantly thicker in GKF treated rats compared with in loperamide-treated rats. In isolated rat ileum, loperamide produced inhibition of ileal motility. Pretreatment with methanolic extracts of GKF in isolated rat ileum prevented inhibition by loperamide. These findings indicated that the GKF was effective for alleviation of inhibition of colonic peristalsis by loperamide and that GKF might be of value in the prevention of constipation.

A New Kiwifruit Variety, 'Halla Gold' with High Soluble Solids Content and Early Harvesting

“…참다래 과실에는 비타민 C의 함량이 아주 높고 미국 식품 의약국(FDA)이 규정한 20대 영양소가 골고루 함유되어 있 으며 특히 암 예방과 변비해소 효과 등이 알려지면서 그 소 비량이 급증하고 있다 (Collins et al, 2001(Collins et al, , 2003Cui et al, 2002;Ferguson, 1999;Kim et al, 2011) (Cui et al, 2002;Huang et al, 2004;Kim et al, 2007aKim et al, , 2007bKim et al, , 2009KSVC, 2011) 종이 육성, 보급되기 시작하고 있다 (Kim et al, 2007a(Kim et al, , 2007b(Kim et al, , 2009 1 and 2). 잎은 아주 넓은 난형으로 넓은 난형인 '제시골드'나 'Hort16A'와는 다르다.…”

Current status and prospects of kiwifruit (Actinidia chinensis) genomics

“…그 러나 본격적으로 전 세계에 널리 알려진 것은 1970년대 이후로써 산업화 역사는 매우 짧은 과수이다. 최근에는 미국 식품의약국(FDA)이 규정한 20대 영양소를 골고루 함유하고 있고 특히, 암 예방과 변비해소 등에 대한 기능 성이 알려지면서 소비량이 계속 증가하고 있다 (Collins et al 2001;Collins et al 2003;Ferguson and Bollard 1990;Kim et al 2011 deliciosa를 대상으로 대과형(>80 g), 고비타민(>120 mg/100 g) 및 고당도(>14°Brix 이상)의 우량계통을 선발하였고 1990 년대 이후에야 Actinidia 종들간 교배육종을 통한 신품종 육성이 이루어지고 있다 (Kim et al 2007a(Kim et al , 2007bKim et al 2009 (Frédrique et al 1994;Kim et al 2003;Zhang et al 1983 (Shi et al 2010). 키위는 비타민 C (아스코르브산) 함 량이 매우 높은 과일로 알려져 있다 (Vissers et al 2013 (Crowhurst et al 2008).…”