Effects of Th17 cells and <scp>IL</scp>‐17 in the progression of cervical carcinogenesis with high‐risk human papillomavirus infection

Xue, Jisen; Wang, Yuli; Chen, Cheng; Zhu, Xuejie; Zhu, Hua; Hu, Yan

doi:10.1002/cam4.1279

Cited by 45 publications

(40 citation statements)

References 37 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The IL-17 family is involved in the development of inflammation and host defense against infection by inducing the expression of genes encoding pro-inflammatory cytokines [40,41]. Previous research showed an association between higher IL-17 levels and persistent HPV infection, cervical intraepithelial neoplasia, and cervical cancer [42][43][44][45]. However, here we found no significant difference in IL-17A levels among cervical lesion groups.…”

Section: Discussioncontrasting

confidence: 81%

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

Introduction: Persistent infection with high-risk human papillomavirus (HPV) types is associated with high-grade intraepithelial lesions (HSILs) and invasive cervical cancer. The host immune response plays a key role in whether HPV clears or persists. Most studies on local immune response to HPV collect cervical mucus in order to quantify secreted cytokines; however, cells located inside the tissue can release different cytokines associated with HPV infection. Objective: This study compared the cytokine levels in cervical biopsy specimens of women with abnormal colposcopic findings according to the histopathological results: low-grade intraepithelial lesion (LSIL), HSIL, and no intraepithelial lesion (NSIL). Methods: A cross-sectional study enrolling 141 cervical biopsy specimens examined the cytokine profile for interleukin (IL-) 2, IL-4, IL-10, IL-12, IL-17, and IL-23 and interferon-γ, using the Luminex assay/ELISA. Differences in cytokine levels among the cervical lesion groups were assessed using the Kruskal-Wallis test. Results: The 141 specimens included 90 HSILs, 22 LSILs, and 29 NSILs. IL-2 levels were significantly higher in NSIL samples than in LSIL or in HSIL samples (p = 0.0001) and IL-23 levels were significantly higher in NSIL than in HSIL samples (p = 0.003). Conclusions: Our study shows that in samples from the lesion site point, 2 important pro-inflammatory cytokines, IL-2 and IL-23, are downregulated in HPV lesions.

show abstract

Section: Discussioncontrasting

confidence: 81%

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The potential role of IL-17 in the modulation of the carcinogenic phenotype in the UCC was further reinforced by the finding that IL-17 is produced in vivo by tumor infiltrated CD4+ cells in patients with disease progression ( 100 ). In addition, a tendency for gradual increase in the Th17 ratio in the total CD4+ cells with the worsening of the lesion was shown in patients with cervical lesions associated with HPV, along with the same being observed in relation to IL-17 levels in serum and in cervical tissue homogenate supernatant, suggesting that Th17 and IL-17 cells may contribute to the progression of cervical lesions associated with HPV ( 103 ).…”

Section: Role Of Il-17 In Uccmentioning

confidence: 85%

Th17 response in patients with cervical cancer (Review)

et al. 2018

View full text Add to dashboard Cite

Persistent infection by high-risk human papillomavirus (HR-HPV) is the main risk factor for uterine cervical cancer (UCC). However, viral infection alone is not sufficient for the development and progression of premalignant cervical lesions for cancer. In previous years it has been suggested that the adaptive immune response triggered by the differentiation of naïve helper T cells in Th17 cells may serve an important role in disease development. It has been hypothesized that Th17 cells may be involved in the promotion of UCC, as high levels of interleukin 17 (IL17) expression have been detected in the mucosa of the uterine cervix of patients affected by the disease. However, the role of Th17 cells in the tumor development and progression remains unclear. It is believed that the immune response of the Th17 type during persistent infection of the genital tract with HR-HPV triggers chronic inflammation with a long duration with the production of IL17 and other pro-inflammatory cytokines, creating a favorable environment for tumor development. These cytokines are produced by immune system cells in addition to tumor cells and appear to function by modulating the host immune system, resulting in an immunosuppressive response as opposed to inducing an effective protective immune response, thus contributing to the growth and progression of the tumor. In the present review, the latest advances are presented about the function of Th17 cells and the cytokines produced by them in the development and progression of UCC.

show abstract

“…A previous study has found that IL-17 was expressed by neutrophils, mast cells, innate lymphoid cells, and T H 17 cells in human cervical cancer (58). Another study found that IL-17 levels in cervical tissue homogenates of CIN and cervical cancer were significantly higher than that in normal cervical tissue homogenate (59). MTA1 expression level has been associated with migration and invasion of cervical cancer cells (60).…”

Section: Discussionmentioning

confidence: 97%

Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression

Guo

Zhang

et al. 2019

Front. Oncol.

View full text Add to dashboard Cite

Interleukin-17 (IL-17) has been shown to promote development of prostate, colon, skin, lung, breast, and pancreatic cancer. The purpose of this study was to determine if IL-17 regulates MTA1 expression and its biological consequences. Human cervical cancer HeLa and human prostate cancer DU-145 cell lines were used to test if IL-17 regulates metastasis associated 1 (MTA1) mRNA and protein expression using quantitative reverse transcription-polymerase chain reaction and Western blot analysis, respectively. Cell migration and invasion were studied using wound healing assays and invasion chamber assays. Thirty-four human cervical tissues were stained for IL-17 and MTA1 using immunohistochemical staining. We found that IL-17 increased MTA1 mRNA and protein expression in both cell lines. Cell migration was accelerated by IL-17, which was abolished by knockdown of MTA1 expression with small interference RNA (siRNA). Further, cell invasion was enhanced by IL-17, which was eliminated by MTA1 knockdown. Human cervical intra-epithelial neoplasia (CIN) and cervical cancer tissues had increased number of IL-17-positive cells and MTA1 expression compared to normal cervical tissues. The number of IL-17-positive cells was positively correlated with MTA1 expression. These findings demonstrate that IL-17 upregulates MTA1 mRNA and protein expression to promote HeLa and DU-145 cell migration and invasion.

show abstract

Effects of Th17 cells and IL‐17 in the progression of cervical carcinogenesis with high‐risk human papillomavirus infection

Cited by 45 publications

References 37 publications

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study

Downregulation of IL-2 and IL-23 in Cervical Biopsies of Cervical Intraepithelial Lesions: A Cross-Sectional Study

Th17 response in patients with cervical cancer (Review)

Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression

Contact Info

Product

Resources

About