Effects of tetrabromobisphenol A (TBBPA) on the reproductive health of male rodents: A systematic review and meta-analysis

Wu, Huihui; Wang, Jinhang; Xiang, Ying; Li, Lü; Qie, Hantong; Ren, Meng; Lin, Aoxiang; Qi, Fang

doi:10.1016/j.scitotenv.2021.146745

Cited by 29 publications

(6 citation statements)

References 65 publications

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“…p < 0.1 indicated that there was heterogeneity among studies and a random effect model was used, while a fixed effect model was used when there was no heterogeneity between studies (p > 0.1). 29 Q statistics was used to measure heterogeneity 30,31 which was composed of inter-group heterogeneity (Q M ) and intra-group heterogeneity (Q E ). The Q M value and inter-group heterogeneity are positively correlated.…”

Section: Meta-analysismentioning

confidence: 99%

The properties and efficacy of S-nZVI as a remediation agent in response to its preparation process and reaction conditions: a truth from meta-analysis

Qie,

Liu,

Hou

et al. 2023

Environ. Sci.: Nano

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Section: Meta-analysismentioning

confidence: 99%

The properties and efficacy of S-nZVI as a remediation agent in response to its preparation process and reaction conditions: a truth from meta-analysis

Qie,

Liu,

Hou

et al. 2023

Environ. Sci.: Nano

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“…[7] Because of the wide distribution of TBBPA, its potential health risks have drawn increasing attention, and its toxicity has been explored in multiple studies by various cells and animal models. [1,2,8] It is reported that TBBPA exerts reproductive toxicity, [9] neurotoxicity, [10] and promote inflammatory response. [11,12] Because the liver is an important metabolism organ and is linked to a variety of liver diseases, its liver toxicity has raised concerns.…”

Section: Introductionmentioning

confidence: 99%

Insight into Tetrabromobisphenol A‐Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing

Bai,

Zhu,

et al. 2023

Advanced Biology

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In recent years, there has been growing concern over the rising incidence of liver diseases, with increasing exposure to environmental toxins as a significant contributing factor. However, the mechanisms of liver injury induced by environmental pollutants are largely unclear. Here, using tetrabromobisphenol A (TBBPA), a widely used brominated flame retardant, as an example, environmental toxin‐induced liver toxicity in mice is characterized via single‐cell sequencing technology. Heterogeneous gene expression profiles after exposure to TBBPA in major cell types of the liver are demonstrated. In hepatocytes, pathway analysis of differentially expressed genes reveals the enhanced interferon response and diminished metabolic processes. The disrupted endothelial functions in TBBPA‐treated cells are then shown. Moreover, the activation of M2‐polarization in Kupffer cells, as well as activated effector T and B cells are unveiled in TBBPA‐treated cells. Finally, ligand‐receptor pair analysis shows that TBBPA disrupts cell‐cell communication and induces an inflammatory microenvironment. Overall, the results reveal that TBBPA‐induced dysfunction of hepatocytes and endothelial cells may then activate and recruit other immune cells such as Kuffer cells, and T/NK cells into the liver, further increasing inflammatory response and liver injury. Thus, the results provide novel insight into undesiring environmental pollutant‐induced liver injury.

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“…In addition to sites associated with the manufacturing and processing of TBBPA-based materials, the main TBBPA emission sources are e-waste recycling sites and wastewater treatment plants [4], with the highest reported TBBPA concentration registering up to 732 mg/kg dw in wastewater sewage sludge [5]. Previous studies have shown that TBBPA can disrupt thyroid and estrogen hormone function, as well as induce liver toxicity, cytotoxicity, and neurotoxicity [6]. Due to its toxicity, high hydrophobicity, and lipid solubility, TBBPA can easily be accumulated and transported in the food chain via different mediums, which could potentially pose a threat to human health [7].…”

Section: Introductionmentioning

confidence: 99%

Occurrence and Distribution of Tetrabromobisphenol A and Diversity of Microbial Community Structure in the Sediments of Mangrove

Jiang

Wang

et al. 2023

Biology

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The occurrence and distribution characteristics of tetrabromobisphenol A (TBBPA) and its relationship with microbial community diversity in different mangrove sediments need further investigation. The results of this study indicated levels of TBBPA in mangrove sediments from the Zhangjiang Estuary (ZJ), Jiulongjiang Estuary (JLJ), and Quanzhou Bay (QZ) in Southeast China ranging from 1.80 to 20.46, 3.47 to 40.77, and 2.37 to 19.83 ng/g dry weight (dw), respectively. Mangrove sediments from JLJ contained higher levels of TBBPA, possibly due to agricultural pollution. A correlation analysis revealed a significant correlation between total organic carbon (TOC), total nitrogen (TN), and TBBPA distribution in ZJ and JLJ mangrove sediments, but not in QZ mangrove sediments. TOC significantly affected the distribution of TBBPA in mangrove sediments, but pH had no effect. High-throughput 16S rRNA gene sequencing showed that Pseudomonadota dominated the sediment bacteria followed by Chloroflexota, Actinobacteota, Bacillota, Acidobacteriota, Bacteroidota, and Aminicenantes in mangrove sediments. Although the microbial community structure of the ZJ, JLJ, and QZ mangrove sediments was similar, the taxonomic profile of their sensitive responders differed markedly. The genus Anaerolinea was dominant in the mangrove sediments and was responsible for the in situ dissipation of TBBPA. Based on redundancy analysis, there was a correlation between TBBPA, TOC, TN, C/N, pH, and microbial community structure at the genus level. Combining TBBPA, TN, and TOC may induce variations in the microbial community of mangrove sediments.

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Effects of tetrabromobisphenol A (TBBPA) on the reproductive health of male rodents: A systematic review and meta-analysis

Cited by 29 publications

References 65 publications

The properties and efficacy of S-nZVI as a remediation agent in response to its preparation process and reaction conditions: a truth from meta-analysis

The properties and efficacy of S-nZVI as a remediation agent in response to its preparation process and reaction conditions: a truth from meta-analysis

Insight into Tetrabromobisphenol A‐Associated Liver Transcriptional Landscape via Single Cell RNA Sequencing

Occurrence and Distribution of Tetrabromobisphenol A and Diversity of Microbial Community Structure in the Sediments of Mangrove

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