Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome

Rodríguez-Tolrà, Josep; Barreda, J. Torremadé; Río, Luis Del; Gregorio, Silvana Di; Miranda, Eladio Franco

doi:10.3109/13685538.2013.839648

Cited by 21 publications

(10 citation statements)

References 23 publications

(32 reference statements)

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“…One possible explanation for the differences between our findings and those of Hildreth et al (22) may relate to the study duration (12 mo vs. 12 wk). Other studies reporting that T treatment alone decreases fat mass in men >50 yr compared with placebo have employed interventions for a minimum of 6 mo (51)(52)(53)(54)(55). Further supporting the notion that longer periods of combined T þ Ex administra-tion may be necessary to yield additive benefit for fat mass, Bhasin et al (21) did not report any changes in fat mass following a 10-wk intervention, despite using supraphysiological T dose.…”

Section: Discussionmentioning

confidence: 93%

Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels

Chasland

Yeap

Maiorana

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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As men age, serum testosterone (T) concentrations decrease, as do fitness, strength and lean mass. Whether testosterone treatment confers additive benefit to reverse these changes when combined with exercise training in middle-to-older aged men remains unclear. We assessed the effects of T treatment and exercise, alone and in combination, on aerobic capacity (VO2peak), body composition and muscular strength in men 50-70yrs, waist circumference ≥95cm and low-normal serum T (6-14nmol·L−1). Participants (n=80) were randomised to AndroForte5® (Testosterone 5.0%w/v, 100mg/2mL) cream (T), or matching placebo (P), applied transdermally daily, and supervised centre-based exercise (Ex) or no additional exercise (NEx), for 12-weeks. Exercise increased VO2peak and strength vs non-exercise (VO2peak: T+Ex:+2.5, P+Ex:+3.2mL·kg−1·min−1, P<0.001; leg press: T+Ex:+31, P+Ex:+24kg, P=0.006). T treatment did not affect VO2peak or strength. Exercise decreased total (T+Ex:-1.7, P+Ex-2.3kg, P<0.001) and visceral fat (T+Ex:-0.1, P+Ex:-0.3kg, P=0.003), and increased total (T+Ex:+1.4, P+Ex:+0.7kg, P=0.008) and arm lean mass (T+Ex:+0.5, P+Ex:+0.3kg, P=0.024). T treatment did not affect total or visceral fat, but increased total (T+Ex:+1.4, T+NEx:+0.7kg, P=0.015), leg (T+Ex:+0.3, T+NEx:+0.2kg, P=0.024) and arm lean mass (T+Ex:+0.5, T+NEx:+0.2kg, P=0.046). T+Ex increased arm lean mass (T+Ex:+0.5kg vs P+NEx:-0.0kg, P=0.001) and leg strength (T+Ex:+31 vs P+NEx:+12kg, P=0.032) compared to P+NEx, with no other additive effects. Exercise training was more effective than T treatment in increasing aerobic capacity and decreasing total and visceral fat mass. T treatment at therapeutic doses increased lean mass but conferred limited additional benefit when combined with exercise. Exercise should be evaluated as an anti-ageing intervention in preference to testosterone treatment in men.

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Section: Discussionmentioning

confidence: 93%

Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels

Chasland

Yeap

Maiorana

et al. 2021

American Journal of Physiology-Heart and Circulatory Physiology

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“…Rodrıguez-Tolra et al demonstrated clearly that TRT in men with TD decreased fat mass overall, and to the greatest extent in the android and gynecoid regions and caused improvements in body composition, increasing lean mass, primarily in arms and legs [ 83 ].…”

Section: Recommendation 6: Body Composition and Mobilitymentioning

confidence: 99%

Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men

Lunenfeld

Mskhalaya²,

Zitzmann³

et al. 2015

The Aging Male

271

285

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Hypogonadism or Testosterone Deficiency (TD) in adult men as defined by low levels of serum testosterone accompanied by characteristic symptoms and/or signs as detailed further on can be found in long-recognized clinical entities such as Klinefelter syndrome, Kallmann syndrome, pituitary or testicular disorders, as well as in men with idiopathic, metabolic or iatrogenic conditions that result in testosterone deficiency. These recommendations do not encompass the full range of pathologies leading to hypogonadism (testosterone deficiency), but instead focus on the clinical spectrum of hypogonadism related to metabolic and idiopathic disorders that contribute to the majority of cases that occur in adult men.

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“…A total of 84 studies that tested the effect of TRT on body composition met all our selection criteria. Forty-seven of these studies were RCTs ( (9,143,150,184,186,206,221,317). Two studies reported an increase in BMI (189,298).…”

Section: Scientific Literature On Trt Weight Bmi and Abdominal Obesmentioning

confidence: 99%

Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans

Tchernof

Brochu

Maltais‐Payette

et al. 2018

Comprehensive Physiology

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The sexual dimorphism in human body fat distribution suggests a causal role for sex hormones. This is of particular importance when considering the role of excess visceral adipose tissue accumulation as a critical determinant of obesity-related cardiometabolic alterations. Scientific literature on the modulation of body fat distribution by androgens in humans is abundant, remarkably inconsistent and difficult to summarize. We reviewed relevant literature on this topic, with a particular emphasis on androgen replacement, androgen effects on selected parameters of adipose tissue function and adipose tissue steroid-converting enzymes. In men, low androgenic status mostly reflected by reduced total testosterone is a frequent feature of visceral obesity and the metabolic syndrome. Regarding testosterone therapy, however, studies must be appreciated in the context of current controversies on their cardiovascular effects. Analyses of available studies suggest that decreases in waist circumference in response to testosterone are more likely observed in men with low levels of testosterone and high BMI at study onset. In women with androgen excess, higher testosterone and free testosterone levels are fairly consistent predictors of increased abdominal and/or visceral adipose tissue accumulation, which is not the case in nonhyperandrogenic women. Regarding mechanisms, androgens decrease adipogenesis and markers of lipid storage in vitro in men and women. Evidence also suggest that local steroid transformations by adipose tissue steroid-converting enzymes expressed in a depot-specific fashion may play a role in androgen-mediated modulation of body fat distribution. Accumulating evidence shows that androgens are critical modulators of body fat distribution in both men and women. © 2018 American Physiological Society. Compr Physiol 8:1253-1290, 2018.

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Effects of testosterone treatment on body composition in males with testosterone deficiency syndrome

Abstract: Testosterone treatment in males with TDS leads to body changes affecting lean and fat mass with significant improvement in AMS scores, and has an excellent safety profile.

Cited by 21 publications

References 23 publications

Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels

Testosterone and exercise: effects on fitness, body composition, and strength in middle-to-older aged men with low-normal serum testosterone levels

Recommendations on the diagnosis, treatment and monitoring of hypogonadism in men

Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans

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