Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep

Shi, Ruijun; Li, Shuwei; Liu, Penggang; Guo, Lili; Gong, Shujuan; Wan, Yu

doi:10.1007/s11250-022-03216-5

Cited by 1 publication

(3 citation statements)

References 46 publications

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“…The skin's response to DHT is mainly androgen receptors (ARs) [29][30][31]. With the increase of cellular levels of DH pression also significantly increases [31]. The experimental results validate tion, as shown in Figure 5D.…”

Section: Nmn Downregulation Ar Expression and Activation Wnt/β-cateni...supporting

confidence: 65%

“…Primary HDPCs were used as an in vivo model for relevant AGA conditions. The skin’s response to DHT is mainly influenced by androgen receptors (ARs) [ 29 , 30 , 31 ]. With the increase of cellular levels of DHT, the AR expression also significantly increases [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…The skin’s response to DHT is mainly influenced by androgen receptors (ARs) [ 29 , 30 , 31 ]. With the increase of cellular levels of DHT, the AR expression also significantly increases [ 31 ]. The experimental results validate this correlation, as shown in Figure 5 D. The control groups exhibited a significant upregulation in AR gene expression, demonstrating the effectiveness of the stimulation conditions in our tests.…”

Section: Resultsmentioning

confidence: 99%

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β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Xu,

Dai,

et al. 2024

Molecules

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β-Nicotinamide mononucleotide (NMN) has shown promising effects on intestinal health, and it is extensively applied as an anti-aging and Alzheimer’s disease therapeutic, due to its medicinal properties. The effects of NMN on the growth of mouse hair were observed after hair removal. The results indicated that NMN can reverse the state of hair follicle atrophy, hair thinning, and hair sparsity induced by dihydrotestosterone (DHT), compared to that of minoxidil. In addition, the action mechanisms of NMN promoting hair growth in cultured human dermal papilla cells (HDPCs) treated with DHT were investigated in detail. The incubation of HDPCs with DHT led to a decrease in cell viability and the release of inflammatory mediators, including interleukin-6 (IL-6), interleukin-1Beta (IL-1β) and tumor necrosis factor Alpha (TNF-α). It was found that NMN can significantly lower the release of inflammatory factors induced by DHT in HDPCs. HDPCs cells are protected from oxidative stress damage by NMN, which inhibits the NF-κB p65 inflammatory signaling pathway. Moreover, the levels of androgen receptor (AR), dickkopf-1 (DKK-1), and β-catenin in the HDPCs were assessed using PCR, indicating that NMN can significantly enhance the expression of VEGF, reduced IL-6 levels and suppress the expression of AR and DKK-1, and notably increase β-catenin expression in DHT-induced HDPCs.

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Section: Nmn Downregulation Ar Expression and Activation Wnt/β-cateni...supporting

confidence: 65%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

Xu,

Dai,

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

Effects of testosterone on skin structure and factors related to androgen conversion and binding in Hetian sheep

Cited by 1 publication

References 46 publications

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

β-Nicotinamide Mononucleotide Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

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