Effects of Testosterone on Glycosaminoglycans in the Prostate, Seminal Vesicles and Salivary Glands of the Rat

Kofoed, J. A.; Houssay, Alberto B.; Tocci, A.A.; Curbelo, H.M.; Gamper, C.H.

doi:10.1677/joe.0.0510465

Cited by 15 publications

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“…In their study the most abundant GAG was DS, a finding that we have confirmed. In the rat ventral prostate GAG are androgen sensitive [22] and in various other tissues, e.g., uterus [23] and aorta [24], GAG are influenced by hormonal manipulations. In view of the suspected role of androgens and oestrogens in the etiology of BPH [25], the effect of hormonal manipulation on human prostatic GAG would be of interest.…”

Section: Discussionmentioning

confidence: 99%

The glycosaminoglycans of normal and hyperplastic prostate

Klerk

1983

The Prostate

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A study has been made of the glycosaminoglycans (GAG) of the fetus, normal adult, and benign hyperplastic prostate. In the adult normal prostate dermatan sulphate (DS) is the predominant GAG. The central zone has a slightly higher chondroitin sulphate (Ch AC) content than the peripheral zone. Fetal prostates (22-27 weeks gestation) contain no heparan sulphate (HS). Benign prostatic hyperplasia (BPH) has an increased content of Ch AC. On separation of BPH stroma and epithelium, the epithelial fraction contains only Ch AC and DS. HS and hyaluronic acid (HA) are confined to the prostatic stroma.

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Section: Discussionmentioning

confidence: 99%

The glycosaminoglycans of normal and hyperplastic prostate

Klerk

1983

The Prostate

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“…Biochemical studies have shown that stromal GAGs change during normal development, prostatic hyperplasia, and carcinoma [21-231. The concentration of GAGs in the prostate gland and seminal vesicles of the rat has been shown to change on castration and testosterone ad-ministration after orchidectomy [24]; testosterone has been demonstrated to play a role in the metabolism of GAGs [25]. It has been reported that GAGs are more concentrated at the epithelial-mesenchymal interface where the epithelial morphogenesis is active [26].…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural localization of proteoglycans by cationic dyes in the epithelial—stromal interface of the guinea pig lateral prostate

Chan

Wong

1989

The Prostate

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Proteoglycans (PGs) in the epithelial-stromal interface of the guinea pig lateral prostate were localized at ultrastructural level, using cuprolinic Blue (CB), alcian Blue (AB), and ruthenium red (RR). After staining with CB or AB according to the critical electrolyte concentration method (CEC), PGs appeared as short electron-dense filaments. According to their sizes and location, three type (T1, T2, T3) of CB-stained filaments were identified. T1 filaments were short (25 nm) and were found on both sides of the lamina densa of the basal laminae of the prostatic epithelium, smooth muscle cells, and capillary endothelial cells. They were regularly spaced with an interval of 60 nm. T1 filaments were more randomly distributed in the lamina densa. T2 CB filaments were approximately 30-40 nm long and closely associated with the collagen fibrils. They were usually arranged perpendicular to the long axis of collagen fibrils also at intervals of 60 nm. T3 filaments were found in different regions of the lamina propria, including: 1) reticular layer (pars fibroreticularis) below the basal lamina; 2) interstitial spaces; 3) closely associated with the cell surfaces of fibroblasts; and 4) around the collagen fibrils. Their sizes were variable (60-100 nm) and more densely stained. AB revealed similar patterns of PG distribution, except that the three types of PG filaments were longer but thinner. When the tissues were stained with RR, or RR-AB combined, PGs appeared as dense granules of various sizes, instead of filaments. Their locations and distributions were similar to those of the CB filaments, except that in the case of combined RR-AB treatment the PG granules were linked by a fine filamentous network, suggesting the interconnecting nature of the PGs and other extracellular components.

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“…It has been observed that prostatic atrophy after castration causes changes in the qualitative and quantitative levels of GAGs and that these changes can be reversed with androgen replacement (Kofoed et al, ; Terry and Clark, ). Moreover, it was observed that the changes are more pronounced in the ventral prostate of rodents than in the dorsal and lateral lobes (Terry and Clark, ).…”

Section: Hormonal Regulation Of the Prostate Glandmentioning

confidence: 99%

Heparanase 1 involvement in prostate physiopathology

Barbosa

Cervigne

Carvalho

et al. 2017

Cell Biology International

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The prostate is a compound exocrine gland of the male reproductive tract universally present in mammals. It is highly responsive to androgen and can be committed by a variety of pathological complications as prostatitis, benign, and malignant proliferative changes, which may be intensified by aging. Prostate intensively turnover its extracellular matrix (ECM) either at homeostasis or disease which includes a dynamically change of glycosaminoglycan composition during the life of an individual. Among the different enzymes playing a role in such changes, heparanase-1 is responsible for cleaving heparan sulfate (HS) at a limited number of sites, clearly involved in tissue remodeling. Its activity has been strongly implicated in cell invasion associated with cancer metastasis, a consequence of the structural modification that loosens the ECM barrier. In the present review we focuses in some aspects of the prostate physiology and diseases, particular prostate cancer, evidencing how the HPSE-1 activity encompasses the relationship of both processes.

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Effects of Testosterone on Glycosaminoglycans in the Prostate, Seminal Vesicles and Salivary Glands of the Rat

Cited by 15 publications

References 0 publications

The glycosaminoglycans of normal and hyperplastic prostate

The glycosaminoglycans of normal and hyperplastic prostate

Ultrastructural localization of proteoglycans by cationic dyes in the epithelial—stromal interface of the guinea pig lateral prostate

Heparanase 1 involvement in prostate physiopathology

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