Effects of terpenes in the treatment of visceral leishmaniasis: A systematic review of preclinical evidence

Raimundo, Vagner Dias; Carvalho, Renner Philipe Rodrigues; Machado‐Neves, Mariana; Silva, Eduardo de Almeida Marques da

doi:10.1016/j.phrs.2022.106117

Cited by 10 publications

(7 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plant secondary metabolites represent viable options for current treatments of infectious diseases. Notably, terpenes constitute the largest and most diverse group of phytoconstituents from diverse natural sources [ 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

et al. 2023

View full text Add to dashboard Cite

Malachra alceifolia Jacq. (family Malvaceae), known as “malva,” is a medicinal plant used as a traditional therapy in many regions of America, Africa and Asia. Traditionally, this plant is used in the form of extracts, powder and paste by populations for treating fever, stomachache, inflammation, and parasites. However, the ethnopharmacological validation of M. alceifolia has been scarcely researched. This study showed that the chloroform fraction (MA-IC) and subfraction (MA-24F) of the leaves of M. alceifolia exhibited a potential antileishmanial activity against axenic amastigotes of Leishmania mexicana pifanoi (MHOM/VE/60/Ltrod) and had high and moderate cytotoxic effects on the viability and morphology of macrophages RAW 264.7. This study reports, for the first time, possible terpenoid metabolites and derivatives present in M. alceifolia with activity against some biosynthetic pathways in L. mexicana amastigotes. The compounds from the subfractions MA-24F were highly active and were analyzed by gas chromatography-mass spectrometry (GC-MS) and by a molecular docking study in L. mexicana target protein. This study demonstrates the potential modes of interaction and the theoretical affinity energy of the metabolites episwertenol, α-amyrin and methyl commate A, which are present in the active fraction MA-24F, at allosteric sites of the pyruvate kinase, glyceraldehyde-3-phosphate dehydrogenase, triose phosphate isomerase, aldolase, phosphoglucose isomerase, transketolase, arginase and cysteine peptidases A, target proteins in some vital biosynthetic pathways were responsible for the survival of L. mexicana. Some phytoconstituents of M. alceifolia can be used for the search for potential new drugs and molecular targets for treating leishmaniases and infectious diseases. Furthermore, contributions to research and the validation and conservation of traditional knowledge of medicinal plants are needed globally.

show abstract

Section: Resultsmentioning

confidence: 99%

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Despite the fact that conventional antidepressant therapy can help relieve symptoms of depression, concerns have been raised regarding complementary therapies due to the drawbacks of the current medications. Phytochemical constituents, a ubiquitous class of plant secondary metabolites, have revealed their therapeutic benefits in many indications, including mental disorders ( Raimundo et al, 2022 ). The use of phytochemicals is a complementary method to conventional antidepressants to provide therapeutic advantages and avoid unwanted adverse reactions.…”

Section: Phytotherapy On Depression Targeting Neurotrophic Factorsmentioning

confidence: 99%

Neurotrophic basis to the pathogenesis of depression and phytotherapy

et al. 2023

View full text Add to dashboard Cite

Depression is a major neuropsychiatric disease that considerably impacts individuals’ psychosocial function and life quality. Neurotrophic factors are now connected to the pathogenesis of depression, while the definitive neurotrophic basis remains elusive. Besides, phytotherapy is alternative to conventional antidepressants that may minimize undesirable adverse reactions. Thus, further research into the interaction between neurotrophic factors and depression and phytochemicals that repair neurotrophic factors deficit is highly required. This review highlighted the implication of neurotrophic factors in depression, with a focus on the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), and nerve growth factor (NGF), and detailed the antidepressant activities of various phytochemicals targeting neurotrophic factors. Additionally, we presented future opportunities for novel diagnostic and therapeutic strategies for depression and provided solutions to challenges in this area to accelerate the clinical translation of neurotrophic factors for the treatment of depression.

show abstract

“…Isoprenoids have shown diverse biological activities in vitro and in vivo studies, including anti‐inflammatory, antioxidant, antiaggregant, anticoagulant, antitumor, antifungal, and antibacterial activity (Tetali, 2019; Wiart et al., 2023). Of note are its effects on various parasites such as Entamoeba histolytica (Menezes & Tasca, 2023), Trypanosoma cruzi (Moreno et al., 2018), Plasmodium falciparum (Tabefam et al., 2018), S. mansoni (McManus et al., 2018), Leishmania spp (Raimundo et al., 2022) and E. multilocularis (Liu et al., 2021). Therefore, in this review, we will examine the effects of the most promising terpene compounds with anti‐leishmanicidal, anti‐schistosomicidal, and anti‐echinococcal activity in vitro isolated from plants in the last 7 years.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, there is a continuous effort to discover new drugs to improve the treatment of these parasitosis. Plants possess numerous biologically active chemical compounds, including flavonoids, anthocyanidins, coumarins, and terpenes, which exhibit antiparasitic activity (Da Silva et al., 2018; Raimundo et al., 2022; Soto‐Sánchez, 2022). Terpenes are a very diverse group of molecules with very different structures and functions, of regular size, consisting of complete isoprene units (C 5 H 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Terpenes are a very diverse group of molecules with very different structures and functions, of regular size, consisting of complete isoprene units (C 5 H 8 ). Based on the number of carbon units, terpenes are classified as hemiterpenes (C5), monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30), tetraterpenes, polyterpenes, and meroterpenes (> C40) (Chen et al., 2021; Raimundo et al., 2022). In addition to regular terpenes, plants also synthesize homoterpenes (also known as nor‐terpenes), which can be generated through the degradation of regular terpenes (Zhou & Pichersky, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Soto‐Sánchez

2024

Chem Biol Drug Des

View full text Add to dashboard Cite

Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Terpenes are secondary metabolites with pharmacological potential. This aim of this mini‐review is to explore the most promising natural terpenes with anti‐leishmanicidal, anti‐schistosomicidal, and anti‐echinococcal activity, their mechanisms of action, and their efficacy as combination therapy. The study identified a tetracyclic diterpenoid, a sesquiterpene lactone, and a triterpene with the highest biological activity against leishmaniasis. Additionally, a triterpenoid and a tetraterpene showed potent activity against schistosomiasis and echinococcosis, respectively. Compounds have antiparasitic effects by inducing cell death, inhibiting cell stress‐related proteins, degrading extracellular matrix, and modulating immune and inflammatory responses. The employment of combination therapy and terpene nanotransporters appears to enhance the antiparasitic activity of these compounds. Although identifying specific molecular targets is necessary, the use of terpenes in combination therapy presents a safe and highly promising approach for the rational development of more potent and selective antiparasitic drugs.

show abstract

Effects of terpenes in the treatment of visceral leishmaniasis: A systematic review of preclinical evidence

Cited by 10 publications

References 88 publications

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

Antileishmanial Activity and In Silico Molecular Docking Studies of Malachra alceifolia Jacq. Fractions against Leishmania mexicana Amastigotes

Neurotrophic basis to the pathogenesis of depression and phytotherapy

Could natural terpenes be an alternative for the treatment of neglected tropical diseases?

Contact Info

Product

Resources

About