Effects of tensile forces on the expression of type III collagen in rat interparietal suture

Tanaka, Eiji; Miyawaki, Y; Tanaka, Masao; Watanabe, Masashi; Lee, K; Pozo, Rodrigo del; Tanne, Kazuo

doi:10.1016/s0003-9969(00)00083-2

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…Quasi-static tensile loads have been applied in vivo to the sagittal suture of rats and mice [29,[57][58][59], the internasal suture of rabbits [60], and the interpremaxillary and intermaxillary sutures of rats and macaques [61][62][63][64][65]. The latter imitates a common orthodontic treatment, rapid palatal expansion.…”

Section: Quasi-static Tension: Elongated Osteogenic Fronts and Widenementioning

confidence: 99%

“…In terms of morphology and cell activity, this strain regime reliably produces increases in suture width, proliferation rate and vascularity, accompanied by increased matrix production and mineralization at the bone fronts [60,62,67]. Sutural ligament fibers and cells are frequently elongated in the direction of tension [57], and type III collagen, which is associated with adaptation to mechanical stress, is induced [58]. The rat midpalatal suture, which normally contains cartilage, is transformed to a ligamentous connection and expresses collagen I instead of collagen II, a response shown to be mediated by upregulation of β 1 integrin and the reorganization of the cytoskeleton [61].…”

Section: Quasi-static Tension: Elongated Osteogenic Fronts and Widenementioning

confidence: 99%

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Mechanical Influences on Suture Development and Patency

Herring¹

2008

Frontiers of Oral Biology

130

150

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In addition to their role in skull growth, sutures are sites of flexibility between the more rigid bones. Depending on the suture, predominant loading during life may be either tensile or compressive. Loads are transmitted across sutures via collagenous fibers and a fluid-rich extracellular matrix and can be quasi-static (growth of neighboring tissues) or intermittent (mastication). The mechanical properties of sutures, while always viscoelastic, are therefore quite different for tensile versus compressive loading. The morphology of individual sutures reflects the nature of local loading, evidently by a process of developmental adaptation. In vivo or ex vivo, sutural cells respond to tensile or cyclic loading by expressing markers of proliferation and differentiation, whereas compressive loading appears to favor osteogenesis. Braincase and facial sutures exhibit similar mechanical behavior and reactions despite their different natural environments.

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Section: Quasi-static Tension: Elongated Osteogenic Fronts and Widenementioning

confidence: 99%

Section: Quasi-static Tension: Elongated Osteogenic Fronts and Widenementioning

confidence: 99%

Mechanical Influences on Suture Development and Patency

Herring¹

2008

Frontiers of Oral Biology

130

150

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“…However, Popowics and Herring (2007) measured elastic moduli in the nasofrontal suture of pigs (Sus scrofa) during relaxation tests, and Tanaka et al (2000b) used the Kelvin model to describe the viscoelastic behaviour of the interparietal suture in rats. Popowics and Herring (2007) carried out a series of relaxation tests and recorded elastic moduli at three different times.…”

Section: Materials Propertiesmentioning

confidence: 99%

“…However, the computational investigation by Tanaka et al (2000b) of time-dependent response in a rat suture assumed the material to be linear viscoelastic.…”

Section: Introductionmentioning

confidence: 99%

Mechanics of cranial sutures during simulated cyclic loading

Jasinoski

Reddy

2012

Journal of Biomechanics

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“…Like other tissues, the up-regulation of genes and transcription factors in sutures is often accompanied by increased protein synthesis. Indeed, increased suture stress has been found to increase the synthesis of type III collagen (Meikle et al, 1984; Tanaka et al, 2000) and alkaline phosphatase activity (Miyawaki and Forbes, 1987). …”

Section: Effect Of Aging On Joint Mechanotransductionmentioning

confidence: 99%

Effect of aging on cellular mechanotransduction

Fannin

Rice

et al. 2011

Ageing Research Reviews

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Aging is becoming a critical heath care issue and a burgeoning economic burden on society. Mechanotransduction is the ability of the cell to sense, process, and respond to mechanical stimuli and is an important regulator of physiologic function that has been found to play a role in regulating gene expression, protein synthesis, cell differentiation, tissue growth, and most recently, the pathophysiology of disease. Here we will review some of the recent findings of this field and attempt, where possible, to present changes in mechanotransduction that are associated with the aging process in several selected physiological systems, including musculoskeletal, cardiovascular, neuronal, respiratory systems and skin.

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Effects of tensile forces on the expression of type III collagen in rat interparietal suture

Cited by 16 publications

References 14 publications

Mechanical Influences on Suture Development and Patency

Mechanical Influences on Suture Development and Patency

Mechanics of cranial sutures during simulated cyclic loading

Effect of aging on cellular mechanotransduction

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