Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA

Chan, Henry Lik‐Yuen; Chan, Chi Kuen; Hui, Aric Josun; Chan, Sing; Poordad, Fred; Chang, Ting Tsung; Mathurin, Philippe; Flaherty, John F.; Lin, Lanjia; Corsa, Amoreena C.; Gaggar, Anuj; Subramanian, G. Mani; McHutchison, John G.; Lee, Sam; Gane, Edward

doi:10.1053/j.gastro.2014.01.044

Cited by 154 publications

(179 citation statements)

References 24 publications

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“…123 In a second double-blind study, HBeAg-positive treatment naïve patients with high HBV DNA and normal ALT levels were randomly assigned to either TDF plus placebo or a combination of TDF plus emtricitabine for 192 weeks. 124 At week 192, 55%…”

Section: Na Plus Na Recommendationsmentioning

confidence: 99%

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Lampertico¹,

Agarwal²,

Berg³

et al. 2017

Journal of Hepatology

4,032

3,081

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Section: Na Plus Na Recommendationsmentioning

confidence: 99%

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Lampertico¹,

Agarwal²,

Berg³

et al. 2017

Journal of Hepatology

4,032

3,081

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“…In the interferon therapy, patients with genotypes A and B have better treatment response than genotypes C and D (35). Recent studies reported that patients infected with genotype B or C had a lower opportunity to gain serological response to tenofovir (36,37).…”

Section: Hbv Genotypingmentioning

confidence: 99%

Diagnosis of hepatitis B

Song

Kim

2016

Ann. Transl. Med.

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Hepatitis B virus (HBV) infection is a major global health problems leading to severe liver disease such as cirrhosis and hepatocellular carcinoma (HCC). HBV is a circular, partly double-stranded DNA virus with various serological markers: hepatitis B surface antigen (HBsAg) and anti-HBs, anti-HBc IgM and IgG, and hepatitis B e antigen (HBeAg) and anti-HBe. It is transmitted by sexual, parenteral and vertical route. One significant method to diminish the burden of this disease is timely diagnosis of acute, chronic and occult cases of HBV. First step of HBV diagnosis is achieved by using serological markers for detecting antigens and antibodies. In order to verify first step of diagnosis, to quantify viral load and to identify genotypes, quantitative or qualitative molecular tests are used. In this article, the serological and molecular tests for diagnosis of HBV infection will be reviewed.

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“…In contrast to peginterferon treatment, NUC treatment is associated with a very slow decline in HBsAg despite strong HBV DNA suppression, indicating weak immune clearance of the virus [24,25]. In HBeAg-positive patients, those who have HBeAg loss tend to have a faster decline in HBsAg level, but the value of serum HBsAg to determine treatment cessation is uncertain [26,27].…”

Section: Hbsag: From Qualitative To Quantitativementioning

confidence: 99%

Virus and Host Testing to Manage Chronic Hepatitis B

Wong

Chan

2016

Clin Infect Dis.

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Chronic hepatitis B virus (HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma worldwide. The past 50 years have seen rapid developments in HBV testing. Beginning from traditional serologic tests, the availability of sensitive HBV DNA assays allows a thorough understanding of the virology and natural history of chronic HBV infection. Quantification of hepatitis B surface antigen levels reflects the amount and transcriptional activities of covalently closed circular DNA in the liver and may be used to evaluate the stage of disease and guide antiviral therapy. The natural history of chronic HBV infection is also a manifestation of the interaction between the host and the virus, and recent genomic works have shed light on the host-virus relationship and may provide novel tests in the future. This review highlights recent advances in the application of HBV tests in the management of chronic hepatitis B.

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Effects of Tenofovir Disoproxil Fumarate in Hepatitis B e Antigen-Positive Patients With Normal Levels of Alanine Aminotransferase and High Levels of Hepatitis B Virus DNA

Cited by 154 publications

References 24 publications

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection

Diagnosis of hepatitis B

Virus and Host Testing to Manage Chronic Hepatitis B

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