Effects of temperature, inoculum size and starch hydrolyzate concentration on butanediol production by Bacillus licheniformis

Perego, Patrizia; Converti, Attílio; Borghi, Adriana Del

doi:10.1016/s0960-8524(03)00063-4

Cited by 91 publications

(58 citation statements)

References 29 publications

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“…Perego et al (2003) in an optimization study on 2,3-butanediol production by B. licheniformis (NCIMB 8059) found that butanediol concentration has a progressive increase, when temperature was increased from 34 to 37ºC. Conversely, they all sharply decreased over 37ºC, likely due to the well-known thermal inactivation of biosystems at temperature higher than the optimum.…”

Section: Resultsmentioning

confidence: 99%

“…Based on the obtained experimental data, six factors having significant influence on the 2,3-butanediol production were selected for the present Taguchi DOE study to optimize the submerged culture condition. Six factors (temperature, pH, agitation, inoculum's size, acetic acid and succinic acid) which showed significantly influence on the 2,3-butanediol production (Perego et al, 2000;Ghosh and Swaminathan, 2003;Perego et al, 2003) were considered in the present experimental situation ( Table 1).…”

Section: Taguchi Methodologymentioning

confidence: 99%

“…The commercial applications of this diol are not limited to the manufacture of butadiene, or to its use as an antifreeze agent (Perego et al, 2003). It is known as 2,3-butylene glycol, a valuable chemical feedstock because of its application as a solvent, a liquid fuel, and as a precursor of many synthetic polymers and resins.…”

Section: Introductionmentioning

confidence: 99%

“…Interest in microbial production of 2,3-butanediol has been increasing recently due to the large number of industrial applications of this product (Perego et al, 2003). Microbially produced 2,3-butanediol can be converted into 1,3-butadiene, a feedstock chemical currently supplied by the petrochemical industry.…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of 2,3-butanediol production by Klebsiella pneumoniae PTCC 1290: Application of Taguchi methodology for process optimization

Khayati¹,

Pahlevanzadeh²,

Ghaemi³

et al. 2009

Afr. J. Biotechnol.

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2,3-Butanediol production parameter optimization using Klebsiella pneumoniae PTCC 1290 was performed using the design of experiments available in the form of an orthogonal array and a software for automatic design and analysis of the experiments, both based on Taguchi protocol. Optimal levels of physical parameters and key media components namely temperature, pH, inoculum size, agitation, acetic acid and succinic acid were determined. 2,3-Butanediol production obtained from the 18 sets of fermentation experiments performed with the selected factors and levels were further processed with Qualitek-4 software at bigger is better as quality character. The optimized conditions showed an enhanced 2,3-butanediol production of 35.8% (from 11.856 to 18.459 g l -1). The optimal combinations of factors obtained from the proposed design of experiments methodology was further validated by conducting fermentation experiments and the obtained results revealed an enhanced 2,3-butanediol production of 25.8%. Taguchi approach of design of experiments resulted in evaluating the main and interaction effects of the factors individually and in combination.

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Section: Resultsmentioning

confidence: 99%

Section: Taguchi Methodologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhancement of 2,3-butanediol production by Klebsiella pneumoniae PTCC 1290: Application of Taguchi methodology for process optimization

Khayati¹,

Pahlevanzadeh²,

Ghaemi³

et al. 2009

Afr. J. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…2,3-Butanediol (2,3-BDO) is used as a solvent, fuel, and for the production of polymers and chemicals (Perego et al, 2003, Saha & Bothast, 1999. Bacterial 2,3-BDO production has been shown e.g.…”

Section: 3-butanediolmentioning

confidence: 99%