Effects of teduglutide on histological parameters of intestinal anastomotic healing

Costa, Beatriz; Cipriano, Maria Augusta; Gonçalves, Ana Cristina; Abrantes, Ana Margarida; Matafome, Paulo; Seiça, Raquel; Sarmento‐Ribeiro, Ana Bela; Botelho, Maria Filomena; Castro-Sousa, Francisco

doi:10.1007/s10353-017-0478-9

Eur Surg

2017

DOI: 10.1007/s10353-017-0478-9

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Effects of teduglutide on histological parameters of intestinal anastomotic healing

Beatriz Costa

Maria Augusta Cipriano

Ana Cristina Gonçalves

et al.

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“…analysis, a positive impact of teduglutide administration on the reepithelialization and neoangiogenesis events of the proliferative phase of the intestinal anastomotic repair on an experimental model 11 .…”

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Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

et al. 2017

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1 AbstractPurpose: To investigate the inflammatory and redox responses to teduglutide on an animal model of laparotomy and intestinal anastomosis. Methods: Wistar rats (n=62) were allocated into four groups: "Ileal Resection and Anastomosis" vs. "Laparotomy", each one split into "Postoperative Teduglutide Administration" vs. "No Treatment"; and euthanized at the third or the seventh day. Ileal and blood samples were recovered at the baseline and at the euthanasia. Flow cytometry was used to study the inflammatory response (IL-1α, MCP-1, TNF-α, IFN-γ and IL-4 levels), oxidative stress (cytosolic peroxides, mitochondrial reactive species, intracellular glutathione and mitochondrial membrane potential) and cellular viability and death (annexin V/propidium iodide double staining). Results: Postoperative teduglutide treatment was associated with higher cellular viability index and lower early apoptosis ratio at the seventh day; higher cytosolic peroxides level at the third day and mitochondrial overgeneration of reactive species at the seventh day; higher tissue concentration of IL-4 and lower local pro-to-anti-inflammatory cytokines ratio at the seventh day. Conclusion: Those findings suggest an intestinal pro-oxidative and anti-inflammatory influence of teduglutide on the peri-operative context with a potential interference in the intestinal anastomotic healing.

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Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

et al. 2017

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Effects of teduglutide on histological parameters of intestinal anastomotic healing

Cited by 1 publication

References 37 publications

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats

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