Effects of tea tree oil supplementation on growth performance, antioxidant capacity, immune status and microbial community in weaned pigs

Zhang, Gang; Zhao, Jinbiao; Dong, Wenxu; Song, Xiaoming; Zang, Jianjun; Zhang, Shuai; Li, Defa

doi:10.1080/1745039x.2021.1877074

Cited by 13 publications

(9 citation statements)

References 28 publications

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“…Our observation that TTO increased ADG and improved feed conversion rate is consistent with previously reported studies of TTO ( 9 , 10 ) and terpinene in an essential oil blend ( 36 ). The positive effect on ADG and feed conversion rate may be related to the increase in feed intake promoted by TTO.…”

Section: Discussionsupporting

confidence: 93%

“…TTO increased digestibility of protein, fat, and DM in diets. These results are consistent with feeding other essential oils to pigs ( 9 , 39 – 41 ) and broilers ( 42 ). The above essential oils are similar to TTO and contain numerous monoterpenes and sesquiterpene compounds.…”

Section: Discussionsupporting

confidence: 87%

“…TTO contains more than 100 compounds, including α-pinene, terpene-4-ol, linalool, and α-terpenol, which have antibacterial activities (8). Dietary TTO exhibited prophylactic effects on weaned pigs by improving the immune response and growth performance (9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs

et al. 2021

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Tea tree oil (TTO) exerts key roles in improving growth performance of pigs. However, knowledge is limited regarding comparative effects of Encp TTO and Un-encp TTO supplementation on growth performance of pigs. A study determined the effects of TTO or its capsulation on growth performance, antioxidant capacity, and intestinal microbiome of weaned pigs. A total of 144 healthy pigs (8.5 ± 0.24 kg) were subjected to four treatments for a 28-d trial with six replicates per treatment and six pigs per pen: negative control, NC; positive control, PC (antibiotic supplemented); Un-encp TTO (supplemented with unencapsulated TTO); Encp TTO (supplemented with encapsulated TTO). NC, TTO, and PC treatments were compared with regard to improved average daily gain (ADG), average daily feed intake (ADFI), feed conversion rate, nutrient digestibility, and intestinal morphology (p < 0.05) and decreased diarrhea rate. TTO- and PC-treated pigs had higher levels of serum superoxide dismutase, glutathione peroxidase, and immunoglobulin G; lower levels of liver aspartate aminotransferase and alanine aminotransferase; and improved concentrations of interleukin 10 (IL-10), tumor necrosis factor α, and IL-1β (p < 0.05). TTO- and PC-treated pigs had higher abundance of beneficial bacterial species Subdoligranulum and lower abundance of diarrhea associated species Escherichia–Shigella in cecal and colonic digesta (p < 0.05). Encapsulation of TTO preserved more activities of TTO than its unencapsulated counterpart by showing higher ADG, ADFI, and feed conversion rate during day 1 (d1) to d14 (p < 0.05) and tended to lower diarrhea rate (p = 0.083) and improve villous height/crypt depth (VH/CD) ratio (p = 0.089) in jejunum. Encapsulation of TTO also improved antioxidant indexes and decreased liver injury and inflammation accordingly (p < 0.05). Encapsulated TTO-treated pigs had higher abundance of beneficial Clostridium_sensu_stricto_1 and lower the abundance of harmful Escherichia–Shigella in cecal and colonic digesta (p < 0.05). Our results demonstrated TTO benefits on improving growth performance of weaned pigs and further proved that encapsulation of TTO was superior to its unencapsulated counterpart at multiples. Encapsulated TTO was similar to the PC group and could be potentially an alternative of feed antibiotics for weaned pigs.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 87%

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Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs

et al. 2021

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“…Plant essential oils are rich in natural active substances such as terpenes, esters, ketones, and alcohols (Burt, 2004 ). Plant essential oils have attracted the attention of animal husbandry researchers because of their antibacterial, insecticidal, and antioxidant functions (Cappelli et al, 2021 ; Davila‐Ramirez et al, 2020 ; Hall et al, 2021 ; Su et al, 2020 ; Zhang et al, 2021 ). Thus, plant essential oil can promote animal growth and improve intestinal immunity (Puvaca et al, 2020 ; Zhang et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Plant essential oils have attracted the attention of animal husbandry researchers because of their antibacterial, insecticidal, and antioxidant functions (Cappelli et al, 2021 ; Davila‐Ramirez et al, 2020 ; Hall et al, 2021 ; Su et al, 2020 ; Zhang et al, 2021 ). Thus, plant essential oil can promote animal growth and improve intestinal immunity (Puvaca et al, 2020 ; Zhang et al, 2021 ). Nehme et al (Nehme et al, 2021 ) recognized the immunomodulatory molecules of essential oils as a potential therapeutic option in ruminants and monogastric husbandries.…”

Section: Introductionmentioning

confidence: 99%

Dietary tea tree (Melaleuca alternifolia) oil supplementation enhances the expressions of amino acid transporters in goat ileal mucosa and improves intestinal immunity

Chen

Zhou

et al. 2022

Food Science & Nutrition

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Tea tree oil (TTO) is a plant‐derived additive with anti‐inflammatory, bactericidal, and growth‐promoting properties. However, little is known about the effects of TTO on intestinal amino acid transport and immune function in goats. Twenty‐four Ganxi goats (initial body weight of 13.5 ± 0.70 kg) were randomly allotted two treatments and fed either control (CON) or CON+TTO (0.2 ml/kg) diet. The addition of TTO to the diet significantly decreased (p < .05) tumor necrosis factor‐α content and increased (p < .05) interleukin‐2 (IL‐2) content in goat serum; significantly decreased (p < .05) IL‐12, and increased (p < .05) IL‐2 content in goat ileal mucosa; significantly increased (p < .05) secreted IgA content in the jejunal and ileal mucosa; significantly upregulated (p < .05) IL‐2 and downregulated (p < .05) IL‐12 at the mRNA level in the ileal mucosa; significantly elevated the levels of serine, arginine, and total amino acids in the ileal mucosa (p < .05); significantly upregulated (p < .05) SLC1A1 and SLC7A1 in the ileum; and significantly enhanced (p < .05) the protein expression of Claudin‐1 in the ileal mucosa. In summary, adding 0.2 ml/kg of TTO to the diet enhanced SLC1A1 and SLC7A1 mRNA expression in the ileal mucosa, and SLC1A1 and SLC7A1 could transport serine and arginine from the chyme to the ileal mucosa. Thus, increased serine and arginine content in the mucosa could improve intestinal immunity. TTO supplementation upregulated the expression of IL‐2 and Claudin‐1 in goat ileal mucosa, and enhanced immune function in the intestine.

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Effect of thymol on the efficiency of feed utilization and compensatory growth in severe feed-restricted lambs

Ahmadibonakdar,

Vakili,

Javadmanesh

et al. 2024

Trop Anim Health Prod

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Effects of tea tree oil supplementation on growth performance, antioxidant capacity, immune status and microbial community in weaned pigs

Cited by 13 publications

References 28 publications

Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs

Effects of Three-Layer Encapsulated Tea Tree Oil on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota of Weaned Pigs

Dietary tea tree (Melaleuca alternifolia) oil supplementation enhances the expressions of amino acid transporters in goat ileal mucosa and improves intestinal immunity

Effect of thymol on the efficiency of feed utilization and compensatory growth in severe feed-restricted lambs

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