Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Chen, Huize; Deng, Chujun; Meng, Zeyu; Meng, Shumei

doi:10.3389/fendo.2023.956772

Cited by 6 publications

(3 citation statements)

References 121 publications

(99 reference statements)

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“…CHM, with its rich repository of bioactive components and multi-targeted action, is often lauded for its potential therapeutic benefits against various diseases, including PCOS and its associated complications. [36][37][38] The most common single herbs and herbal formulas identified in our study, namely, Xiang Fu (Cyperi Rhizoma), Yi Mu Cao (Leonuri Herba), Jia Wei Xiao Yao San (Augmented Rambling Powder), and Gui Zhi Fu Ling Wan (Cinnamon and Poria Pill), were frequently prescribed to patients with PCOS and correlated with a lower CHD risk. Xiang Fu plays a crucial role as an important herb in Cangfu-Daotan decoction (CFDTT).…”

Section: Analysis Of Common Chm Combinations and Social Correlation N...mentioning

confidence: 80%

Integrated Chinese and Western Medicine for Coronary Heart Disease Prevention in Polycystic Ovary Syndrome: A 19-Year Nationwide Cohort Study

Liao,

Chien,

et al. 2023

JMDH

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Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Chinese herbal medicine (CHM), a major branch of traditional Chinese medicine, has been reported to exert beneficial effects on PCOS symptoms. However, the relationship between CHM use and the risk of coronary heart disease (CHD) in patients with PCOS remains unclear. The study aimed to investigate the potential protective role of CHM on CHD incidence in patients with PCOS and to understand CHM prescription patterns for PCOS treatment. Methods This retrospective cohort study was performed using data from Taiwan’s Longitudinal Health Insurance Database 2000 (LHID2000). Patients with PCOS were identified, and data on their demographic characteristics, comorbidities, and medication use were extracted. The patients were then divided into CHM and non-CHM users. Results Propensity score matching yielded two balanced cohorts of 2913 individuals each. CHM users demonstrated a 94% reduced risk of CHD compared to non-CHM users (adjusted hazard ratio, 0.06; 95% confidence interval, 0.04–0.1) during the 19-year follow-up period. Stratified analysis confirmed the benefits of CHM treatment on the incidence of CHD across various subgroups. The key elements identified in the CHM prescription patterns associated with reduced CHD risk were Xiang Fu, Yi Mu Cao, Jia Wei Xiao Yao San, and Gui Zhi Fu Ling Wan. Conclusion This study provides evidence that CHM may protect against CHD development in patients with PCOS. It is also highlight the most frequently prescribed CHM for mitigating CHD risk among patients with PCOS. These findings lay the groundwork for future studies to confirm and elucidate CHM’s therapeutic mechanisms in PCOS-related CHD prevention, offering a significant contribution to the field.

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Section: Analysis Of Common Chm Combinations and Social Correlation N...mentioning

confidence: 80%

Integrated Chinese and Western Medicine for Coronary Heart Disease Prevention in Polycystic Ovary Syndrome: A 19-Year Nationwide Cohort Study

Liao,

Chien,

et al. 2023

JMDH

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“…Traditional Chinese Medicine (TCM) literature has described conditions similar to PCOS in chapters related to metrorrhagia, amenorrhea, abdominal pain, and infertility. The treatment regimen centers around rectifying the balance among kidney essence, Tiangui, Chongren, and uterus (9). Although various medications have been proposed for treating PCOS, they have limitations such as adverse effects, low compliance, low efficacy, and contraindications in certain instances (10).…”

Section: Introductionmentioning

confidence: 99%

Yishen Huatan Huoxue decoction and quercetin ameliorate decidualization dysfunction in polycystic ovary syndrome: A comprehensive investigation combining clinical trial and experimental studies

Wang,

Li,

Zhou

et al. 2024

DD&T

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Quercetin, polycystic ovary syndrome, decidualization, traditional Chinese medicine Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disorder characterized by a complex pathogenesis and limited treatment options. Yishen Huatan and Huoxue decoction (YHHD), as a traditional Chinese Medicine formula, has shown effectiveness in treating PCOS. However, the specific mechanisms by which YHHD exerts its therapeutic effects remain unclear. In this study, we performed to investigate the therapeutic effects of YHHD and quercetin on dehydroepiandrosteroneinduced PCOS mice, and examine the effect of quercetin on the decidualization of T-HESCs under hyperinsulinemic conditions. The results showed that YHHD could reduce early miscarriage rates in PCOS patients and significantly improved glucose metabolism disorders, sex hormone levels, and the estrous cycles in PCOS mice. Quercetin could alleviate effect of high insulin levels and restore the low expression of insulin receptor substrate1/2 (IRS1/2) and glucose transporte 4 (GLUT4) in T-HESCs, demonstrating its potential to mitigate hyperinsulin-induced decidualization dysfunction via the GLUT4 signaling pathway mediated by IRS1/2. This study provides valuable molecular insights of YHHD and highlight the therapeutic potential of quercetin in treating decidualization dysfunction in PCOS.

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“… 2 According to the Traditional Chinese Medicine (TCM), PCOS is the main factor leading to infertility in young women, 3 and the main cause of infertility caused by PCOS is located in the uterus and involves kidneys, spleen, and liver. 4 The main pathogenesis of ovulatory dysfunction infertility caused by PCOS, according to TCM, is spleen and kidney yang deficiency, combined with various syndromes such as phlegm dampness, liver depression, and blood stasis. 5 , 6 In terms of treatment, the main approach should be, therefore, to warm the spleen and tonify the kidney, while also using methods such as dispelling phlegm, soothing the liver, and resolving blood stasis.…”

Section: Introductionmentioning

confidence: 99%

The effect of Bushenhuoxue nutritional decoction in the treatment of overweight patients with polycystic ovarian syndrome

Fu,

Chen,

Huang

et al. 2024

Pak J Med Sci

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Objective: To assess the effect of Traditional Chinese Medicine (TCM) nutrition treatment (Bushenhuoxue nutritional decoction) in overweight patients with polycystic ovary syndrome (PCOS). Methods: Retrospective analysis of 96 overweight patients with PCOS who received treatment in our hospital from October 2020 to June 2022 was done. Among them, 46 patients received routine drug treatment and daily dietary intervention (control group), while 50 patients received additional TCM nutrition support in addition to routine treatment (observation group). Glucose and lipid metabolism indicators and hormone levels were compared between the two groups before and after the treatment. Ovulation rate, pregnancy rate, and adverse reactions were compared between both groups one year after the treatment. Results: After treatment, the improvement of glucose and lipid metabolism indicators and hormone levels in the observation group was significantly better than in the control group (P<0.05). After treatment, the TCM syndrome scores of the two groups were lower than that before treatment (P < 0.001), and the TCM syndrome scores of the observation group was lower than that of the control group (P < 0.001).Ovulation and pregnancy rates were significantly higher in the observation group compared to the control group at 1-year follow up (P<0.05), and the incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). Conclusions: Combined with conventional drug treatment, TCM nutrition treatment can significantly improve glucose and lipid metabolism, hormone levels, and TCM syndrome of overweight PCOS patients, increase the ovulation and pregnancy rates, and reduce potential adverse reactions. doi: https://doi.org/10.12669/pjms.40.6.9304 How to cite this: Fu J, Chen Y, Huang Z, Wang X. The effect of Bushenhuoxue nutritional decoction in the treatment of overweight patients with polycystic ovarian syndrome. Pak J Med Sci. 2024;40(6):1105-1110. doi: https://doi.org/10.12669/pjms.40.6.9304 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of TCM on polycystic ovary syndrome and its cellular endocrine mechanism

Cited by 6 publications

References 121 publications

Integrated Chinese and Western Medicine for Coronary Heart Disease Prevention in Polycystic Ovary Syndrome: A 19-Year Nationwide Cohort Study

Integrated Chinese and Western Medicine for Coronary Heart Disease Prevention in Polycystic Ovary Syndrome: A 19-Year Nationwide Cohort Study

Yishen Huatan Huoxue decoction and quercetin ameliorate decidualization dysfunction in polycystic ovary syndrome: A comprehensive investigation combining clinical trial and experimental studies

The effect of Bushenhuoxue nutritional decoction in the treatment of overweight patients with polycystic ovarian syndrome

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