Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention

Bo, Simona; Gambino, Roberto; Ciccone, Giovannino; Rosato, Rosalba; Milanesio, Nadia; Villois, Paola; Pagano, Gianfranco; Cassader, Maurizio; Gentile, Luigi; Durazzo, Marilena; Cavallo‐Perin, P.

doi:10.3945/ajcn.2009.28379

Cited by 19 publications

(27 citation statements)

References 30 publications

(51 reference statements)

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“…The independent association of TCF7L2 polymorphism with increasing fasting glucose values in the follow-up may represent a marker for higher metabolic risk, which is useful for developing more closely tailored lifestyle preventive approaches as we have recently reported (12). …”

Section: Discussionmentioning

confidence: 83%

Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Hyperglycemia in an Adult Italian Population-Based Cohort

Gambino

Gentile

et al. 2009

Diabetes Care

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OBJECTIVETo assess whether TCF7L2 polymorphism has a role in the deterioration of glycemic control.RESEARCH DESIGN AND METHODSMetabolic variables were evaluated at baseline and after 6-year follow-up in 1,480 Caucasian subjects from a population-based cohort.RESULTSAt baseline, T-allele carriers showed significantly lower BMI and homeostasis model assessment for β-cell function (HOMA-B) values and higher fasting glycemia and diabetes prevalence. At follow-up, fasting glucose and HOMA-B index were increased and reduced, respectively, in carriers of the T-allele. Incident impaired fasting glucose (IFG) and incident diabetes were 5.7, 10.7, 16.9% and 1.6, 1.7, 3.0% in the CC, CT, and TT genotypes, respectively. In a multiple logistic regression model, the association between incident IFG and the T-allele was significant (odds ratio [OR] 2.08 [95% CI 1.35–3.20] and 3.56 [2.11–5.98] in CT and TT genotypes, respectively).CONCLUSIONSThe T-allele of TCF7L2 rs7903146 polymorphism was independently associated with increasing fasting glucose values toward hyperglycemia in the follow-up.

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Section: Discussionmentioning

confidence: 83%

Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Hyperglycemia in an Adult Italian Population-Based Cohort

Gambino

Gentile

et al. 2009

Diabetes Care

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“…Twenty-two studies included both men and women, one study [ 22 ] included only women, and one study [ 14 ] included only men. Within the eligible studies, eight [ 10 , 12 , 13 , 15 , 19 , 26 , 28 , 31 ] involved subjects with diabetes, three [ 8 , 21 , 27 ] involved subjects with MetS, twelve [ 8 , 10 , 12 – 16 , 20 , 24 , 25 , 27 , 28 ] involved nondiabetic healthy subjects, and eight [ 9 , 11 , 17 , 18 , 22 , 23 , 29 , 37 ] involved general (community-based/population-based) subjects. Overall, 52,785 subjects were enrolled in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Wang

Song

Srivastava

et al. 2015

Journal of Diabetes Research

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Background. The results from published studies regarding association of transcription factor 7-like 2 (TCF7L2) variant rs7903146 with dyslipidemia have been conflicting and inconclusive. Methods. We carried out a meta-analysis that aimed to investigate the association of the rs7903146 variant with plasma lipid levels using electronic database and published studies. Data was extracted by a standard algorithm. Dominant, recessive, homozygote, and heterozygote comparison models were utilized. Results. 24 studies incorporating 52,785 subjects were included in this meta-analysis. Overall, the minor allele (T) was associated with lower risk for hypertriglyceridemia in subjects with type 2 diabetes (dominant model: SMD = −0.04, 95% CI (−0.08, 0.00), P = 0.048, P heterogeneity = 0.47; recessive model: SMD = −0.10, 95% CI (−0.18, −0.02), P = 0.01, P heterogeneity = 0.56). No association was found between minor (T) allele and plasma TC, LDL-c, or HDL-c levels in subjects with type 2 diabetes or metabolic syndrome (MetS) and no association was found between minor (T) allele and plasma TG levels in nondiabetic subjects. Conclusions. Our meta-analysis indicated the association between TCF7L2 rs7903146 polymorphism and low plasma triglyceride (TG) level in subjects with type 2 diabetes. No association was found between rs7903146 variant and plasma lipids in nondiabetic subjects.

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“…Epidemiological studies have reported that the negative eff ect of several obesity-and T2DM-associated genes may be attenuated in individuals with higher PA levels or healthy lifestyle, whereas low PA and western dietary pattern have been found to accentuate it. ( Bo et al, 2009 ;Florez et al, 2006 ;Haupt et al, 2010 ;Wang et al, 2007 ). The minor allele of PPARgamma gene has also been associated with substantially increased risk for T2DM and atherosclerosis ( Deeb et al, 1998 ; Temelkova-Kurktschiev et al, 2004 ).…”

Section: Lifestyle and Genetics In Obesity And Type 2 Diabetes ▼mentioning

confidence: 99%

Lifestyle and Genetics in Obesity and type 2 Diabetes

Temelkova‐Kurktschiev

Stefanov

2011

Exp Clin Endocrinol Diabetes

107

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Obesity and type 2 diabetes mellitus are multifactorial health threats caused by a complex interplay between genetic predisposition and the environment with dramatically increasing worldwide prevalence. The role of heritability in their etiology is well recognized, however, the numerous attempts made in order certain genetic variants determining individual susceptibility to be identified have had limited success, until recently. At present the advancements in human genetics and the utilization of the genome-wide association approach have led to the identification of over 20 genetic loci associated with, respectively obesity and type 2 diabetes. Most of the genes identified to date, however, have modest effect on disease risk suggesting that both diseases are unlikely to develop without the individual being exposed to obesity- and/or type 2 diabetes-promoting environment. Indeed, unhealthy lifestyle, characterized by physical inactivity and food overconsumption is an unequivocally established risk factor for obesity and type 2 diabetes. Numerous epidemiological studies and randomized controlled trials, on the other hand, have demonstrated that lifestyle modification is effective in obesity and type 2 diabetes prevention. Furthermore, gene-lifestyle interaction studies suggest that genetic susceptibility to obesity and type 2 diabetes may be partially or totally kept under control by healthy lifestyle or lifestyle modification and that lifestyle determines whether an individual is likely to develop the disease. Inherited factors, however, seem to influence individual response to a lifestyle intervention program and even the motivation for lifestyle change. Personalized interventions according to genotype may be, therefore, considered in the future. By then lifestyle modification targeting dietary change and increased physical activity may be recommended for successful obesity and type 2 diabetes prevention irrespectively of genetic susceptibility.

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Effects of TCF7L2 polymorphisms on glucose values after a lifestyle intervention

Cited by 19 publications

References 30 publications

Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Hyperglycemia in an Adult Italian Population-Based Cohort

Transcription Factor 7-Like 2 (TCF7L2) Polymorphism and Hyperglycemia in an Adult Italian Population-Based Cohort

The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in Type 2 Diabetes: A Meta-Analysis

Lifestyle and Genetics in Obesity and type 2 Diabetes

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