Effects of taurine on calcium binding and accumulation in rabbit hippocampal and cortical synaptosomes

Łazarewicz, Jerzy W.; Noremberg, Krystyna; Lehmann, Anders; Hamberger, Anders

doi:10.1016/0197-0186(85)90164-0

Cited by 43 publications

(17 citation statements)

References 17 publications

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“…Now, taurine has been shown to be involved in many important physiological functions [for review, see [4]] e.g., as a trophic factor in the development of the CNS [5] and, for instance, kittens from the taurine-depleted mothers exhibit a delay in the migration of cells in the cerebellum and in the visual cortex [5]. It also serves in maintaining the structural integrity of the membrane [6], regulating calcium binding and transport [7,8], as an osmolyte [9,10], a neuromodulator [11], a neurotransmitter [12-18] and a neuroprotector against L-glutamate (L-Glu)-induced neurotoxicity [19,20]. In this article, the role of taurine in the central nervous system (CNS) as a neurotransmitter, a neuro-protective agent and a potent regulator for intracellular calcium homeostasis will be reviewed.…”

Section: Introductionmentioning

confidence: 99%

Role of taurine in the central nervous system

2010

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Taurine demonstrates multiple cellular functions including a central role as a neurotransmitter, as a trophic factor in CNS development, in maintaining the structural integrity of the membrane, in regulating calcium transport and homeostasis, as an osmolyte, as a neuromodulator and as a neuroprotectant. The neurotransmitter properties of taurine are illustrated by its ability to elicit neuronal hyperpolarization, the presence of specific taurine synthesizing enzyme and receptors in the CNS and the presence of a taurine transporter system. Taurine exerts its neuroprotective functions against the glutamate induced excitotoxicity by reducing the glutamate-induced increase of intracellular calcium level, by shifting the ratio of Bcl-2 and Bad ratio in favor of cell survival and by reducing the ER stress. The presence of metabotropic taurine receptors which are negatively coupled to phospholipase C (PLC) signaling pathway through inhibitory G proteins is proposed, and the evidence supporting this notion is also presented.

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Section: Introductionmentioning

confidence: 99%

Role of taurine in the central nervous system

2010

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“…Taurine has been shown to have various functions such as bile formation in the liver (Vessey 1978), osmoregulation (Lasserre and Gilles 1971), the stabilization of membranes (Huxtable and Bressler 1973), and calcium binding and transport regulation (Lazarewicz et al 1985;Lombardini 1985). Taurine also acts as an antioxidant and protects against the toxicity of various substances in vivo (Green et al 1991;Gürer et al 2001;Balkan et al 2002;Sinha et al 2008).…”

Section: Discussionmentioning

confidence: 97%

The synthesis and role of taurine in the Japanese eel testis

et al. 2011

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In teleost fish, the progestin 17α, 20β-dihydroxy-4-pregnen-3-one (DHP) is an essential component of the spermatogenesis pathway. In a series of investigations on the mechanisms underlying progestin-stimulated spermatogenesis, we have found that DHP up-regulates the expression of cysteine dioxygenase1 (CDO1) in the Japanese eel testis. CDO1 is one of the enzymes involved in the taurine biosynthesis pathway. To evaluate whether taurine is synthesized in the eel testis, cysteine sulfinate decarboxylase (CSD), another enzyme involved in taurine synthesis, was isolated from this species. RT-PCR and in vitro eel testicular culture revealed that although CSD was also expressed in eel testis, neither DHP nor other sex steroids affect CSD mRNA expression in a similar manner to CDO1. Using an in vitro eel testicular culture system, we further investigated the effects of DHP on taurine synthesis in the eel testis. HPLC analysis showed that DHP treatment significantly increases the taurine levels in the eel testis. These results suggest that DHP promotes taurine synthesis via the up-regulation of CDO1 mRNA expression during eel spermatogenesis. Furthermore, we observed from our analysis that although taurine does not induce complete spermatogenesis, it promotes spermatogonial DNA synthesis and the expression of Spo11, a meiosis-specific marker. These data thus suggest that taurine augments the effects of sex steroids in the promotion of spermatogonial proliferation and/or meiosis and hence that taurine plays important roles in spermatogenesis.

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“…It has also been indicated that androgen regulates some of these proteinases [6]. Taurine is the most abundant intracellular amino acid, and has been shown to have various functions, such as bile formation in the liver [9], osmoregulation [10], the stabilization of membranes [11], calcium binding and transport regulation [12,13], and cell volume regulation and resistance to stress [14]. Taurine is present in male reproductive organs [15,16], and stimulates testosterone secretion in the rat testis in vivo and in vitro [17].…”

Section: Introductionmentioning

confidence: 99%

Trypsin Regulates Meiotic Initiation in the Japanese Eel (Anguilla japonica) by Promoting the Uptake of Taurine into Germ Cells During Spermatogenesis1

Higuchi

Miura

Iwai

et al. 2013

Biology of Reproduction

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Meiosis is a unique and critical process in reproduction. Although the key molecular components of meiosis have been identified, the molecular mechanisms regulating the entry into this pathway remain unclear. We previously demonstrated that a progestin in teleost fish, 17alpha, 20beta-dihydroxy-4-pregnen-3-one, is essential for meiotic initiation, and up-regulates taurine synthesis and the production of trypsin in Sertoli cells. In the present study, we found that trypsin promotes the uptake of taurine into germ cells through the up-regulation of solute carrier family 6 (neurotransmitter transporter, taurine), member 6 (Slc6a6) expression. We further found that this up-regulation of the taurine signal is required for Spo11a expression and meiotic initiation.

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Effects of taurine on calcium binding and accumulation in rabbit hippocampal and cortical synaptosomes

Cited by 43 publications

References 17 publications

Role of taurine in the central nervous system

Role of taurine in the central nervous system

The synthesis and role of taurine in the Japanese eel testis

Trypsin Regulates Meiotic Initiation in the Japanese Eel (Anguilla japonica) by Promoting the Uptake of Taurine into Germ Cells During Spermatogenesis1

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