Effects of task-based rehabilitative training combined with PTEN/SOCS3 coinhibition promotes axon regeneration and upper extremity skilled motor function recovery after cervical spinal cord injury in adult mice

Pan, Lu; Yi, Lingrong; Liu, Yuan; Liu, Li; Zhu, Ying; Zhong, Juan; Wang, Yunhang; Yin, Ying; Yu, Lehua; Tan, Botao; Yang, Chen

doi:10.1016/j.neulet.2023.137121

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…While the present review does not included viral or gene treatments, the following treatment effects have been studied: chemogenic activation of propriospinal neuron with non-invasive intravenous AAV9 delivery [ 101 ], KLF6 expression to enhance CST axon sprouting [ 102 ], PTEN inhibition to enhance CST axon sprouting and synapse reformation [ 103 ], PTEN/SOCS3 co-inhibition to promote axonal regeneration [ 104 ], ADAMTS4 induction to decrease lesion size [ 63 ], MMP-9 deletion to attenuate remote microglial activation and restore TNF-α expression [ 97 ], and blocking of NB-3 (contactin-6) to promote synapse reformation between serotonergic Raphe Spinal tract regenerative axons and motor neurons [ 105 ]. These factors could be potential targets of medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Do Pharmacological Treatments Act in Collaboration with Rehabilitation in Spinal Cord Injury Treatment? A Review of Preclinical Studies

Tashiro,

Shibata,

Nagoshi

et al. 2024

Cells

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There is no choice other than rehabilitation as a practical medical treatment to restore impairments or improve activities after acute treatment in people with spinal cord injury (SCI); however, the effect is unremarkable. Therefore, researchers have been seeking effective pharmacological treatments. These will, hopefully, exert a greater effect when combined with rehabilitation. However, no review has specifically summarized the combinatorial effects of rehabilitation with various medical agents. In the current review, which included 43 articles, we summarized the combinatorial effects according to the properties of the medical agents, namely neuromodulation, neurotrophic factors, counteraction to inhibitory factors, and others. The recovery processes promoted by rehabilitation include the regeneration of tracts, neuroprotection, scar tissue reorganization, plasticity of spinal circuits, microenvironmental change in the spinal cord, and enforcement of the musculoskeletal system, which are additive, complementary, or even synergistic with medication in many cases. However, there are some cases that lack interaction or even demonstrate competition between medication and rehabilitation. A large fraction of the combinatorial mechanisms remains to be elucidated, and very few studies have investigated complex combinations of these agents or targeted chronically injured spinal cords.

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