Effects of Tarantula cubensis D6 on aflatoxin-induced injury in biochemical parameters in rats

Karabacak, Mürsel; Eraslan, Gökhan; Kanbur, Murat; Sarıca, Zeynep Soyer

doi:10.1016/j.homp.2015.02.005

Cited by 32 publications

(19 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, our results show how prolonged exposure to AFB1 is related to a significant increase in oxidative stress; in particular, the brain tissue of mice exposed to AFB1 (750 µg/kg orally every three days for 46 days) showed a significant increase in lipid peroxidation and also an impairment in those endogenous systems responsible for endogenous antioxidant defense such as GSH, SOD and CAT. Our results are therefore in line with other studies that have also demonstrated the induction of oxidative stress in the brains and livers of rodents that were subjected to different schemes of AFB1 administration [56,57]. GSH, catalyzed by GST and conjugated with AFB1, is considered the most important detoxification reaction to protect both the liver and extrahepatic tissues from AFB1 toxicity [58,59].…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice

Gugliandolo

Peritore

D’Amico

et al. 2020

Animals

View full text Add to dashboard Cite

Aflatoxin B1 (AFB1) is a mycotoxin commonly present in feed, characterized by several toxic effects. AFB1 seems to have a neurotoxical effect that leads to memory impairment behavior. AFB1 toxicity involves the induction of the oxidative stress pathway, rising lipid peroxidation, and it decreases antioxidant enzyme levels. Hence, in our research, we wanted to evaluate the potential protective effects of quercetin 30 mg/kg in AFB1-mediated toxicity in the brain and the ameliorative effect on behavioral alterations. Oral supplementation with quercetin increased glutathione peroxidase (GSH) levels, superoxidedismutase (SOD) activity and catalase (CAT) in the brain, and it reduced lipid peroxidation in AFB1-treated mice. This antioxidant effect of quercetin in the brains of AFB1-intoxicated mice is reflected in better cognitive and spatial memory capacity, as well as a better profile of anxiety and lethargy disorders. In conclusion, our study suggests that quercetin exerts a preventive role against oxidative stress by promoting antioxidative defense systems and limiting lipid peroxidation.

show abstract

Section: Discussionsupporting

confidence: 92%

Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice

Gugliandolo

Peritore

D’Amico

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…The relationship of ALT elevation and AFB1 and vice versa can also be supported through considering the early work of Thaxton and Hamilton (18) and Gawai et al (19) in which the proved the elevation of ALT, as indication of acute liver injury, in birds that had been given a single dose of aflatoxin compared to control untreated birds. The reported increase of ALT in AFB1 positive patients can also find support in more recent studies which demonstrate the significant increase of ALT among other biochemical parameters in rats fed AFB1 (20)(21)(22). Therefore this study exhibits similarity to the previously research which prove that AFB1-induced liver injury can be attributed to the oxidative stress.…”

Section: Discussionsupporting

confidence: 89%

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Farag

Alayobi²,

Alsaleh

et al. 2016

Preprint

View full text Add to dashboard Cite

Abstract:Background: Exposure to chronic low levels of aflatoxin B1 (AFB1) contamination can lead to immune suppression and nutritional consequences that might greatly contributed in the increase of hepatocellular carcinoma (HCC). The toxicity of AFB1 is greatly vary between different population, affected by age, gender, and environmental factors. Material and subjects: Aflatoxin B1 (AFB1) was measured in 50 blood samples collected from non B, C hepatitis viruses and non CMV-Ab liver disease patients from different general hospitals and polyclinic in KSA during period 01-2013 to 06-2014. All Patients demonstrate elevation of ALT and AST with unknown etiology. Serum samples were obtained and kept at −20 °C for AFB1detection. Results: Out of the 50 blood samples, 38 demonstrate a detectable serum level of AFB1 while the remaining 12 patients were AFB1 negative and used as control participants. While AST was non-significantly different in AFB1 exposed patients, ALT was significantly higher in AFB1 positive samples compared to control AFB1-negative. AFB1 was positively correlated with AST and ALT as liver function enzymes and with age as a risk factor of long duration of AFB1 chronic exposure. Multiple linear regression analysis ascertained the association between AFB1 chronic exposure and ALT increase in liver dysfunction Saudi patients. Conclusion: Measurement of elevated ALT as marker of liver injury in AFB1 chronically exposed Saudi patients can help to avoid the future development of HCC. Moreover, early detection of AFB1 exposure, together with early vaccination against HBV and HCV can remove the synergistic effects of these two etiological factors and thus decrease the risk of developing liver cancer.

show abstract

“…In this study, the contents of H 2 O 2 , MDA and LPO in the liver and spleen of broilers were significantly increased by dietary AFB 1 , indicating that a low level of AFB 1 (22.5–25.0 μg/kg) could increase the oxidative status in the liver and spleen of broilers. Similar toxic effects of AFB 1 on oxidative status were observed in the liver and spleen of rats [32], and broilers [33,34]. …”

Section: Discussionmentioning

confidence: 55%

Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1

Liu

Zhao

et al. 2016

Toxins

View full text Add to dashboard Cite

This study was conducted to investigate the toxic effects of aflatoxin B1 (AFB1) and evaluate the effects of sporoderm-broken spores of Ganoderma lucidum (SSGL) in relieving aflatoxicosis in broilers. A total of 300 one-day-old male Arbor Acre broiler chickens were randomly divided into four dietary treatments; the treatment diets were: Control (a basal diet containing normal peanut meal); AFB1 (the basal diet containing AFB1-contaminated peanut meal); SSGL (basal diet with 200 mg/kg of SSGL); AFB1+SSGL (supplementation of 200 mg/kg of SSGL in AFB1 diet). The contents of AFB1 in AFB1 and AFB1+SSGL diets were 25.0 μg/kg in the starter period and 22.5 μg/kg in the finisher period. The results showed that diet contaminated with a low level of AFB1 significantly decreased (p < 0.05) the average daily feed intake and average daily gain during the entire experiment and reduced (p < 0.05) serum contents of total protein IgA and IgG. Furthermore, a dietary low level of AFB1 not only increased (p < 0.05) levels of hydrogen peroxide and lipid peroxidation, but also decreased (p < 0.05) total antioxidant capability, catalase, glutathione peroxidase, and hydroxyl radical scavenger activity in the liver and spleen of broilers. Moreover, the addition of SSGL to AFB1-contaminated diet counteracted these negative effects, indicating that SSGL has a protective effect against aflatoxicosis.

show abstract

Effects of Tarantula cubensis D6 on aflatoxin-induced injury in biochemical parameters in rats

Abstract: Our results indicated that Tarantula cubensis D6 partially neutralized the deleterious effects of aflatoxin.

Cited by 32 publications

References 40 publications

Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice

Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice

Relationship between Aflatoxin B1 Exposure and Etiology of Liver Disease in Saudi Arabian Patients

Protective Effects of Sporoderm-Broken Spores of Ganderma lucidum on Growth Performance, Antioxidant Capacity and Immune Function of Broiler Chickens Exposed to Low Level of Aflatoxin B1

Contact Info

Product

Resources

About