Effects of tapeworm infection on absorption and excretion of zinc and cadmium by experimental rats

Sloup, Vladislav; Jankovská, Ivana; Száková, Jiřina; Magdálek, Jan; Sloup, S.; Langrová, Iva

doi:10.1007/s11356-018-3397-9

Cited by 6 publications

(7 citation statements)

References 40 publications

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“…Based on the results of Cadkova et al (2013), we can expect the amount of zinc excreted in the feces to be higher after the intake of zinc lactate than it would be after the intake of phytobound Zn. This is confirmed by a comparison with the results of one of our previous publications (Sloup et al, 2018), where we evaluated how tapeworms affect the excretion of zinc and cadmium in the Values expressed as the median ± standard deviation in the group Table 3. Zinc dosages and levels of Zn excreted in feces (mg) over a 6-week period.…”

Section: Discussionsupporting

confidence: 72%

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Excretion of dietary zinc in mammals (rats) fed overdoses of zinc lactate and infected with tapeworms

et al. 2021

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Summary Tapeworms parasitize at sites that are important for the management of micronutrients, including zinc. Therefore, it has been hypothesized that tapeworms will significantly affect the excretion of zinc in the feces of a host. The aim of this work was to evaluate the effects that tapeworms have on the excretion of zinc in the feces of the host. Rats were divided into 4 groups: groups 0T and MT (infected with Hymenolepis diminuta (Rudolphi, 1819)) and groups 00 and M0 (uninfected). The experimental groups (M0 and MT) were fed a standard rodent compound feed (ST-1) with added zinc lactate; the daily zinc intake was 20.5 mg. The control groups (00 and 0T) were fed only ST-1 with 1.75 mg of added Zn per day. For six weeks, the amount of consumed feed was recorded and fecal samples were taken. The samples were then analyzed by optical emission spectrometry (ICP-OES), and levels of excreted zinc were subsequently calculated as a percentage. The most signifi cant difference in zinc excretion levels between the experimental groups was observed in the third week, when rats infected with tapeworms (MT) excreted substantially lower levels of zinc than did uninfected rats (M0). This difference amounted to 28.36 % (p <0.01). In the control groups, tapeworms affected the excretion of zinc in the feces to a lesser extent, and the most substantial difference in zinc levels was seen in the fifth week (8.46 %). However, there was no signifi cant difference in zinc excretion levels between the control groups during any of the monitored weeks. Tapeworms in the host affect levels of zinc excreted in the feces. However, this is dependent on the amount or form of zinc ingested.

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Section: Discussionsupporting

confidence: 72%

“…The MT group excreted 65 % of ingested zinc, while the infected group that were fed A. halleri excreted 76 % of ingested zinc (Sloup et al, 2018). This can be attributed to the ability of the tapeworm to absorb more zinc from a diet rich in zinc lactate, which has a high bioavailability, than it could from a diet with added A. halleri.…”

Section: Discussionmentioning

confidence: 98%

Excretion of dietary zinc in mammals (rats) fed overdoses of zinc lactate and infected with tapeworms

et al. 2021

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“…Regulation of Zn excretion is mainly through the gastrointestinal tract. Zn is excreted in the feces through food consumption, and fecal Zn also derives from pancreatic and biliary secretion into the intestine [48]. As a consequence, to maintain normal physiological functions, organisms have developed an effective biological mechanism to consume and excrete obligatory trace elements, but they lack a feasible approach to eliminate detrimental heavy metals like Cd, Hg or Pb.…”

Section: Discussionmentioning

confidence: 99%

Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats

Tang

Zhou

Hua

et al. 2020

IJERPH

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To explore the joint toxicity and bio-accumulation of multi-heavy metals and potential chemoprevention strategies, Male Sprague Dawley (SD) rats (n = 30) were treated orally once a week for six months with 500mg/kg•bw of eight heavy metals which were commonly identified in aquatic products in the Ningbo area including chromium, manganese, nickel, copper, zinc, cadmium, mercury, and lead. At the same time, 200mg/kg•bw of epigallocatechin-3-gallate (EGCG), trisodium citrate dihydrate (TCD) or glutathione (GSH) were administered to evaluate their antagonistic effects against adverse effects of multi-heavy metal mixture. The Morris water maze test was used to evaluate spatial learning and memory in the treated rats. Then the rats were anesthetized by pentobarbital sodium (40 mg/kg•bw) to obtain blood samples for biochemical analysis and organs (heart, liver, spleen, lungs, kidneys, brain, testis) to be conducted for biopsy and organ coefficients. Inductively coupled plasma mass spectrometer (ICP-MS) was used to analyze the concentrations of heavy metals. Results indicated that six months of exposure to a multi-heavy metal mixture under this experimental dosage resulted in accumulation in organs and adverse effects on the blood, reproductive system, and liver function. EGCG, TCD or GSH all showed certain chemoprevention effects against the joint toxicity induced by the multi-heavy metal mixture and indicated alleviation and the potential mechanism that also included the promotion of excretion of metals to which animals were exposed.

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“…Prinsip yang di gunakan ialah pipa A berisi larutan HCl dengan konsentrasi C ekivalen/liter. Anoda terbuat dari logam kadmium (174)(175)(176)(177)(178). Jika arus dilewatkan dalam larutan kadmium akan larut dan menghasilkan ion-ion Cd +…”

Section: Metode Batas Bergerak (Moving Boundary)unclassified

SESIUM KLORIDA (CsCl) : TRANSPORT ION DALAM LARUTAN

Firdaus¹,

Zainul²

2018

Preprint

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Sesium klorida adalah senyawa anorganik dengan rumus CsCl. Senyawa ini dapat dengan mudah larut dalam air. Sesium klorida memiliki toksisitas rendah terhadap manusia dan hewan, sedangkan bentuk radioaktif dari senyawa ini dapat dengan mudah mencemari lingkungan karena kelarutan airnya. Senyawa ini digunakan dalam proses sentrifugasi isopicnik dalam pemisahan berbagai jenis DNA dan juga digunakan untuk analisis reagen kimia. Dalam bentuk isotop radio, senyawa ini berguna untuk pengobatan nuklir, yaitu untuk pengobatan kanker. Penelitian ini bertujuan untuk menganalisis interaksi molekuler dan kinetik dari senyawa sesium klorida. Metode yang digunakan adalah dengan pemodelan menggunakan chemoffice serta melalui jurnal hasil penelitian yang berkaitan dengan sesium klorida. Sifat sifat trermokimia dari senyawa sesium klorida dalam fase liquid ∆Ho : -434.47 KJ/mol, so : 101.71 J/molK dan ∆Go : -414.5 KJ/mol. Data ini di peroleh dari wikipedia. Parameter transfer elektron adalah kecepatan drift, nomor angkut, mobilitas ion, difusi dan hukum I Fick.

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Effects of tapeworm infection on absorption and excretion of zinc and cadmium by experimental rats

Cited by 6 publications

References 40 publications

Excretion of dietary zinc in mammals (rats) fed overdoses of zinc lactate and infected with tapeworms

Excretion of dietary zinc in mammals (rats) fed overdoses of zinc lactate and infected with tapeworms

Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats

SESIUM KLORIDA (CsCl) : TRANSPORT ION DALAM LARUTAN

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