Effects of Tacrolimus and Nifedipine, Alone or in Combination, on Gingival Tissues

Abstract

Results suggest that duration of drug administration is a more important risk factor than drug combination. The results include a potentially new insight about PTEN's role in the etiology of drug-induced gingival overgrowth.

Evaluation of gingival alterations in rats medicated with cyclosporine A, tacrolimus and sirolimus: a stereological study

“…Our histomorphometric and stereological results showed that no signs of gingival overgrowth were found in the group administered sirolimus alone, whereas prominent gingival overgrowth was found in groups administered cyclosporine A alone and tacrolimus alone. Many clinical and experimental studies reported that combined drug usage caused much more gingival overgrowth compared with the usage of each drug alone . In contrast to these studies, the results of the present study showed that gingival overgrowth was more prominent in groups administered cyclosporine A and tacrolimus alone compared with combination groups.…”

“…Thirty‐six rats were randomly divided into six groups of six rats each, as follows: cyclosporine group: 30 mg/kg body weight of cyclosporine A was administered daily for 8 wk. tacrolimus group: 1.5 mg/kg body weight of tacrolimus was administered daily for 8 wk. sirolimus group: 1.5 mg/kg body weight of sirolimus was administered daily for 8 wk. cyclosporine + sirolimus group: 30 mg/kg body weight of cyclosporine A and 1.5 mg/kg body weight of sirolimus were administered daily for 8 wk. tacrolimus + sirolimus group: 1.5 mg/kg body weight of tacrolimus and 1.5 mg/kg body weight of sirolimus were administered daily for 8 wk. control group: distilled water was administered daily for 8 wk. …”

“…Oral epithelium thickness (E), and the height (H), and the width (W) of the connective tissue were measured using a modification of the method described by Listgarten (29) and Berglundh et al (30). Oral epithelium thickness was measured at right angles from the outer epithelial surface to the epitheliumconnective tissue border in four different randomly selected areas (E 1 , E 2 , E 3 and E 4 ) of the oral epithelium, whilst width of the connective tissue was measured in three different areas (W 1 , W 2 and W 3 ) of the connective tissue of the first right and left lower molars (26). Evaluation was performed by taking the mean of these measurements.…”

Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats

“…[10141522] In one of the recent experimental studies using the rat model, authors reported DIGO only after 24 weeks of administration of tacrolimus and Nf, alone or in combination. [23] Differences of drug doses were accounted as the possible reason for such variation in findings.…”

miR‐27a‐5p alleviates periodontal inflammation by targeting phosphatase and tensin homolog deleted on chromosome ten

“…Recent research has indicated that PTEN also participates in the inflammatory response. Drug‐induced gingival overgrowth is partly driven by decreased PTEN function, which alters the proliferation–apoptosis ratio of fibroblasts (Pamuk et al., 2013). In fibroblast‐like synoviocytes from clinical rheumatoid arthritis specimens and rat models, PTEN expression is downregulated (X.…”