Effects of T-Activin and Vitamin E on Toxicity and Antitumor Activity of Cyclophosphamide

Abstract

We studied the effect of combination treatment with T-activin and vitamin E on acute toxicity and antitumor activity of cyclophosphamide in mice. Combined administration of these preparations 1.37-fold increased the maximum permissible dose of cyclophosphamide without affecting its LD(50)and delayed mouse death from cyclophosphamide toxicity. Most mice died only 3 days after combination treatment with the test preparations and cyclophosphamide in doses of LD(16)-LD(84). The second peak of death from hematologic toxicity of cyclophosphamide was absent under these conditions. T-activin and vitamin E did not abolish the antitumor effect of cyclophosphamide on mice with subcutaneously implanted P-388 lympholeukemia. Tumor growth was suppressed by 100%.

The use of emoxipin for correction of cyclophosphamide cytotoxicity in experimental animals

“…It can be solved via reduction of toxicity of antitumor drugs. Side effects of antitumor drugs can be determined by their toxic effects on cell membranes, disturbances in LPO regulation, and formation of free radicals [2,4,5]. The use of inhibitors of free-radical reactions as preparations of antioxidant therapy reducing side effects of cytostatics is pathogenetically substantiated.…”