Effects of synthetic cathinone naphyrone in the conditioned place preference test – Evidence of its addictive potential

Danda, Hynek; Pinterova‐Leca, Nikola; Šíchová, Klára; Stefkova-Mazochova, Kristyna; Syrová, Kateřina; Olejníková, Lucie; Končická, Markéta; Mazoch, Vladimír; Lhotková, Eva; Kuchař, Martin; Páleníček, Tomáš

doi:10.1016/j.bbr.2021.113713

Cited by 2 publications

(2 citation statements)

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“…This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. mephedrone (Lisek et al, 2012), methylone (Karlsson et al, 2014;Miyazawa et al, 2011), methylethcathinone (MEC;Xu et al, 2016); naphyrone (Danda et al, 2022), and pentylone (Nadal-Grataco ´s et al, 2021) and are often dose-and sex-dependent. The results reported here are not consistent with this prior work as animals injected with eutylone failed to differ from control subjects in relation to changes in preference for the DPS.…”

Section: Discussionmentioning

confidence: 99%

“…In rats, place preference conditioning, while limited, has also been reported with a variety of synthetic cathinones, including α-PVP (Nelson et al, 2017, 2021; Nelson, López-Arnau, et al, 2019; Nelson, Manke, et al, 2019), MDPV (Gannon et al, 2017; King, Wakeford, et al, 2015; King, Wetzell, et al, 2015; Risca et al, 2020), mephedrone (Lisek et al, 2012), methylone (Karlsson et al, 2014; Miyazawa et al, 2011), methylethcathinone (MEC; Xu et al, 2016); naphyrone (Danda et al, 2022), and pentylone (Nadal-Gratacós et al, 2021) and are often dose- and sex-dependent. The results reported here are not consistent with this prior work as animals injected with eutylone failed to differ from control subjects in relation to changes in preference for the DPS.…”

Section: Discussionmentioning

confidence: 99%

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Conditioned taste avoidance and conditioned place preference induced by the third-generation synthetic cathinone eutylone in female sprague-dawley rats.

Jones¹,

Huang²,

Manke³

et al. 2023

Experimental and Clinical Psychopharmacology

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Recently, use of the synthetic cathinone (aka "bath salt") eutylone has risen in the United States and globally. Due to its novelty in drug markets, its affective properties remain largely uninvestigated. In this context, drugs of abuse have both rewarding and aversive effects and understanding these effects, their relative balance, and factors that impact each are important to understanding the likelihood of drug use and abuse. This investigation attempted to characterize eutylone's rewarding and aversive effects in a combined conditioned taste avoidance/place preference assay. Female Sprague-Dawley rats were given 20-min access to saccharin, injected with one of five doses of eutylone (0, 3, 10, 18, 32 mg/kg; intraperitoneally; IP), and placed on one side of a place conditioning apparatus. On the following day, subjects were given 20-min access to water, injected IP with vehicle, and placed on the other side of the apparatus. After five conditioning cycles, place preference and saccharin avoidance were assessed. Eutylone induced significant taste avoidance but did not significantly increase time spent on the drug-paired side (relative to controls). Excluding animals with high initial side preference, however, eutylone induced a preference at all doses with the high dose group displaying higher preference than controls. There was no significant correlation between eutylone's aversive and rewarding effects. These data indicate that eutylone (like other synthetic cathinones) induces both rewarding and aversive effects and highlight the need to assess the impact of various factors on its affective properties (and their balance) and on their use and abuse. Public Health SignificanceThis study is the first to demonstrate taste avoidance and place preference induced by the novel synthetic cathinone eutylone. Given that a drug's aversive and rewarding effects are thought in balance to mediate its use and abuse, the present study indicates the potential abuse of eutylone and the importance in assessing various factors that could affect this liability.

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