Effects of Sweet Bee Venom Pharmacopuncture Treatment for Chemotherapy-Induced Peripheral Neuropathy

Park, Jae-Woo; Jeon, Ju-Hyun; Yoon, Jeungwon; Jung, Tae‐Young; Kwon, Ki-Rok; Cho, Chong-Kwan; Lee, Yeon‐Weol; Sagar, Stephen M.; Wong, Raimond; Yoo, Hwa‐Seung

doi:10.1177/1534735411413265

Cited by 43 publications

(31 citation statements)

References 23 publications

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“…Moreover, as research continues into the role of pharmacological agents for treatment and/or prevention of oxaliplatin-induced peripheral neuropathy; interest in nonpharmacological treatment options is increasing. Studies have been lacking on non-pharmacological therapy for the treatment of oxaliplatin-peripheral neuropathy, although some clinical studies have been performed on acupuncture for the treatment of chemotherapy-induced peripheral neuropathy [39][40][41][42]. These studies reported improvements following acupuncture in the Visual Analog System (VAS) pain scale, gait, and nerve conduction tests, and reduced use of pain medication.…”

Section: Discussionmentioning

confidence: 96%

Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats

Hsieh

Fan

Yang

2015

Support Care Cancer

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Section: Discussionmentioning

confidence: 96%

Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats

Hsieh

Fan

Yang

2015

Support Care Cancer

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“…Given that most of its usage and relevant studies are from locally limited area, some consideration may be required before it is used worldwide, but the amount of data is increasing continuously [50] and so far the results are promising [51, 52]. For instance, a case series of bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy reported improvement of symptoms in patients and, importantly, there were no related AEs [52]. There was also a noticeable pilot study from University of California, San Francisco, that tested pharmacopuncture for primary dysmenorrhea, and they suggested that pharmacopuncture is highly acceptable among American women as well [51].…”

Section: Discussionmentioning

confidence: 99%

Pharmacopuncture for Cancer Care: A Systematic Review

Cheon

Zhang

Lee

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Background. Pharmacopuncture, injection to acupoints with pharmacological medication or herbal medicine, is a new acupuncture therapy widely available in Korea and China for cancer-related symptoms. However, the evidence is yet to be clear. Objective. To determine pharmacopuncture's effectiveness on cancer-related symptoms. Methods. Eleven databases were searched for randomized controlled trials of pharmacopuncture in cancer patients. The Cochrane risk of bias (ROB) assessment tool was used for quality assessment. Results. Twenty-two studies involving 2,459 patients were included. Five trials of chemotherapy-induced nausea and vomiting (CINV) underwent meta-analysis. Pharmacopuncture significantly relieved severity of CINV compared with control group (3 trials, risk ratio (RR) 1.28, 95% confidence interval (CI) = 1.14–1.44). The frequency of CINV was also significantly reduced with pharmacopuncture (2 trials, RR 2.47, 95% CI = 2.12–2.89). Seventeen trials studied various symptoms, and in most studies, pharmacopuncture significantly relieved pain, ileus, hiccup, fever, and gastrointestinal symptoms and improved quality of life in various cancer patients. ROB was generally high. Conclusion. It may be suggested with caution that pharmacopuncture may help various symptom relief in cancer patients, but it is hard to draw a firm conclusion due to clinical heterogeneity and high ROB of the included studies, hence warranting further investigation.

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“…Adapted from https://www.dolcera.com/wiki/index.php?title=Diabetes products and services. and neuritis [14,15,17,19,[24][25][26][27][28]. Recent studies also confirmed that melittin can significantly reduce blood glucose via insulin secretion and glucose uptake in animal models [21][22][23].…”

Section: Introductionmentioning

confidence: 91%

Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus

Hossen

Gan

Khalil

2017

Journal of Chemistry

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Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic -cells. Other possible mechanisms may involve stimulation of phospholipase A 2 , increase of glucose uptake, improving lipid profile, and/or reduction of inflammation. This review summarizes the various sources, proteomics, biological roles, adverse effects, and medical applications of melittin and its mechanism of action in combating DM.

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Effects of Sweet Bee Venom Pharmacopuncture Treatment for Chemotherapy-Induced Peripheral Neuropathy

Cited by 43 publications

References 23 publications

Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats

Low-level laser therapy alleviates mechanical and cold allodynia induced by oxaliplatin administration in rats

Pharmacopuncture for Cancer Care: A Systematic Review

Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus

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