Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer

Cata, Juan P.; Bauer, Maria; Sokari, Telemate; Ramirez, María F.; Mason, David P.; Plautz, Gregory E.; Kurz, Andrea

doi:10.1016/j.jclinane.2012.12.007

Cited by 68 publications

(48 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…T lymphocytes participate in the immune system and are extensively covered in immune regulation, in ammation and protective immune mechanisms [15]. Cytokines are split into Th1 or Th2 in accordance with the cell of release [16]. Th1 cells and T cytotoxic lymphocytes release Th1 cytokines, which imposes stimulatory actions on cell-mediated immunity [17].…”

Section: Discussionmentioning

confidence: 99%

Effects of Different Anaesthesia Methods on Perioperative Cellular Immune Function and Long-term Outcomes in Patients Undergoing Radical Resection of Esophageal Cancer: A Prospective Cohort Study

Huang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background The present study aimed to analyse the effects of different an anaesthetic method on perioperative cellular immunity and long-term outcomes in patients having undergone oesophageal cancer surgery.Design A Prospective Cohort StudyParticipants 120 cases of patients with oesophageal cancer in the Zhengzhou University People’s Hospital from January 2016 to January 2017 were recruited and randomly split into GA group (general anaesthesia, n=40), PG group (Paravertebral nerve blocks with general anaesthesia, n = 40) and EG group (epidural anaesthesia with general anaesthesia, n=40). Methods Self-rating anxiety scale and visual analogue scale scores were adopted to compare postoperative anxiety and the degree of pain of patients of the three groups. Besides, adverse reactions of patients in the three groups were compared. Pre-operation, the end of operation, postoperative day (POD) 1 and POD 2 levels of interleukin-6 (IL-6), IL-4, tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and the survival of T-cell subsets (CD3+, CD4+, CD8+, CD4+/CD8+) were measured with by either ELISA or flow cytometry.Results In the PG or EG group, VAS scores were lower, and fewer opioids and vasoactive agents were used, as compared with those of the GA group. In both the EG and PG groups, higher CD3+ and CD4+ cell survival and lower levels of Cor, IL-4 and IL-6 were identified at the end of or after the surgery than those in the GA group. Moreover, the postoperative survival cure of the PG and EG groups was better than that of the GA group.Conclusions The combination of paravertebral nerve blocks or epidural anaesthesia and general anaesthesia may improve the perioperative immune function and the long-term outcome for patients having undergone oesophageal cancer surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Different Anaesthesia Methods on Perioperative Cellular Immune Function and Long-term Outcomes in Patients Undergoing Radical Resection of Esophageal Cancer: A Prospective Cohort Study

Huang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This immune suppression is already well documented. 6,23,24 The use of opioids is well known to suppress the immune system. 4,7,8,25 Flurbiprofen is a non-steroidal antiinflammatory drug with targeted analgesic action that inhibits prostaglandin production.…”

Section: Discussionmentioning

confidence: 99%

Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study

et al. 2017

View full text Add to dashboard Cite

Background: Tumors may induce systemic immune dysfunction, which can be aggravated by surgery and anesthesia/analgesia. Data on the effect of flurbiprofen preemptive analgesia on immune dysfunction is limited. The aim of this study was to investigate the effect of flurbiprofen preemptive analgesia on lymphocytes and natural killer (NK) cells in patients undergoing thoracotomy and thoracoscopy radical esophagectomy, and to explore the analgesic methods suitable for tumor patients.Methods: This was a randomized controlled pilot study of 89 patients with esophageal cancer treated with surgery at the Henan Cancer Hospital between January 1, 2015 and December 31, 2016. The patients were divided into three groups: group 1, thoracotomy; group 2, thoracoscopy and laparoscopic surgery; and group 3, flurbiprofen, thoracoscopy, and laparoscopic surgery. CD3+, CD19 +, NK, CD4+, and CD8+ cells in whole blood were measured by flow cytometry 30 minutes before surgery (T0), at the end of the thoracic section of the procedure (T1), and at the end of the operation (T2). Results: There were no significant differences in CD3+, CD19+, CD8+, NK, and CD4+ cells between the three groups or regarding the time points during the procedure (all P > 0.05). Thoracotomy and thoracoscopy surgery resulted in similar immunological outcomes. Conclusion: Flurbiprofen ester preemptive analgesia did not suppress the immune function in patients and could be a safe analgesic method for patients with esophageal cancer undergoing surgery.

show abstract

“…All cytotoxicity experiments were conducted using K562 target erythroleukemic cells (American Type Culture Collection, Manassas, VA). A lactate dehydrogenase release assay was used to calculate the percentage of NK cell cytotoxicity (NKCC) in patients undergoing mastectomy or liver resection and flow cytometry in those undergoing thoracotomy [1,13]. The NKCC was calculated at an effector: target ratio of 10:1 in all patients.…”

Section: Cytotoxicity Studiesmentioning

confidence: 99%

“…NK cells were isolated by positive selection using magnetic cell separation (MACS; Miltenyi Biotec), and NK cell viability was tested with trypan blue. Samples with more than 95% viability were used during the cytotoxicity assay [1].…”

Section: Cytotoxicity Studiesmentioning

confidence: 99%

Innate immune function after breast, lung, and colorectal cancer surgery

Ramirez¹,

Ai²,

Bauer³

et al. 2015

Journal of Surgical Research

Self Cite

View full text Add to dashboard Cite

Effects of surgery, general anesthesia, and perioperative epidural analgesia on the immune function of patients with non-small cell lung cancer

Cited by 68 publications

References 39 publications

Effects of Different Anaesthesia Methods on Perioperative Cellular Immune Function and Long-term Outcomes in Patients Undergoing Radical Resection of Esophageal Cancer: A Prospective Cohort Study

Effects of Different Anaesthesia Methods on Perioperative Cellular Immune Function and Long-term Outcomes in Patients Undergoing Radical Resection of Esophageal Cancer: A Prospective Cohort Study

Effects of preemptive analgesia with flurbiprofen ester on lymphocytes and natural killer cells in patients undergoing esophagectomy: A randomized controlled pilot study

Innate immune function after breast, lung, and colorectal cancer surgery

Contact Info

Product

Resources

About