Effects of surfactant on biofilm formation on silicone nasal splints

Abstract

Biofilms are sessile communities of bacteria embedded in self-produced extracellular polysaccharide matrix and are considered to be responsible for bacterial infections in humans. Topical surfactant use on silicone nasal splints may have a preventive effect on biofilm formation. The objective of this study is to investigate the effect of surfactant-containing nasal solutions on biofilm formation over the surface of silicone nasal splints. Forty patients were randomized after septoplasty to receive surfactant-containing saline solution (group 1) or saline without surfactant (group 2). At the postoperative 48th, 72th and 96th hours, pieces of splint samples were taken and prepared for scanning electron microscopic evaluation. Biofilm formation was observed in 3, 6 and 14 of 20 samples in group 1 (surfactant used) and 3, 14 and 20 of 20 samples in group 2 (control) at 48th, 72th and 96th hours, respectively. Biofilm formation incidences of groups at 48th hour were similar (p > 0.05), whereas it was significantly lower at group 1 regarding 72th and 96th hours (p < 0.05). Surfactant-containing nasal solutions have an inhibitory effect on biofilm formation over the surface of silicone nasal splints especially after 48 h. Surfactant-containing nasal solutions may have an important role in nasal septal dressing in the future.

Intranasal Septal Splints: Prophylactic Antibiotics and Nasal Microbiology

“…18 Different surface properties of intranasal splints have been studied and found to affect the formation of biofilm. 18,20 San et al 18 demonstrated the inhibitory effects of surfactant containing nasal solutions on biofilm formation over the surfaces of ISS. Dag et al 20 suggested that smoother surface properties of silicone splints were associated with lower rates of biofilm formation.…”

“…15,16 Others suggest that ISS provide an environment promoting the formation of microbial biofilms. [17][18][19] Planktonic bacteria may adhere to the surface of the splint and initiate biofilm formation by secreting exopolysaccharide matrix. 18 Different surface properties of intranasal splints have been studied and found to affect the formation of biofilm.…”

“…[17][18][19] Planktonic bacteria may adhere to the surface of the splint and initiate biofilm formation by secreting exopolysaccharide matrix. 18 Different surface properties of intranasal splints have been studied and found to affect the formation of biofilm. 18,20 San et al 18 demonstrated the inhibitory effects of surfactant containing nasal solutions on biofilm formation over the surfaces of ISS.…”

Applications and challenges of using 3D printed implants for the treatment of birth defects

“…However, the contribution of surface roughness on biofilm formation is still debatable due to contradicting observations from different research groups. San et al () have recently found that the smooth texture of silicone materials is also suitable for biofilm formation. In 2014, Leonhard et al also observed a similar effect, and in vitro cell studies conducted cleared the uncertainty of the surface structure factor, as they demonstrated that the formation of biofilms is a time sensitive process (Leonhard et al, ).…”

Collismycin C from the Micronesian Marine Bacterium Streptomyces sp. MC025 Inhibits Staphylococcus aureus Biofilm Formation

“…Currently, there are several ways to inhibit microbial biofilm formation such as surface conditioning by surfactants [ 8 ], inhibiting production of adhesion molecules [ 9 ], suppressing biosynthesis of biofilm matrix [ 10 ], antagonizing microbial quorum sensing signaling [ 11 ], and killing microbes in biofilm [ 12 ].…”