Effects of surface roughness and texture on the bacterial adhesion on the bearing surface of bio-ceramic joint implants: An in vitro study

Lu, Ange; Gao, Yan; Jin, Tan; Luo, Xichun; Zeng, Quanren; Shang, Zhentao

doi:10.1016/j.ceramint.2019.11.139

Cited by 60 publications

(34 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surface of the biomedical device is primarily inspected via surface roughness, which can prevent bacterial adhesion and favor the attachment of bone inducing cells 38 . The surface roughness of ~1.5 μm can stimulate osteoblast cells 38,39 . Figure 5 represents the mean roughness of PEEK/BG coatings and multi‐structured coatings.…”

Section: Resultsmentioning

confidence: 99%

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Nawaz

Rehman

2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

The fabrication of biocompatible and antibacterial coatings on metallic implants remains a significant challenge for load‐bearing orthopedic implants. This study focuses on the electrophoretic deposition of chitosan/gelatin/Ag‐Mn doped mesoporous bioactive glass nanoparticles (Ag‐Mn MBGNs) composite on the PEEK/bioactive glass layer (called as multi‐structured coatings), which had been deposited electrophoretically on 316L stainless steel. The EPD parameters for the deposition of the chitosan/gelatin/Ag‐Mn MBGNs coatings were optimized via Taguchi design of experiment approach. Scanning electron microscopy images confirmed that the chitosan/gelatin/Ag‐Mn MBGNS layer was deposited on the PEEK/BG layer. The addition of biologically active metallic ions (Mn and Ag) and molecules (chitosan) showed a strong effect on the growth of bacteria. Moreover, the inclusion of Mn and Ag showed a negligible toxic effect on the bioactivity (the ability of the coating to form a bond with the natural bone) of the coatings. Furthermore, the multi‐structured coatings presented appropriate wettability and surface roughness for orthopedic applications. Overall, this study provides a direct solution to improve the bioactivity, antibacterial activity, and surface properties of deposited chitosan/gelatin coatings on orthopedic implants that are more manufacturable and translational from research to an industrial scale.

show abstract

Section: Resultsmentioning

confidence: 99%

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Nawaz

Rehman

2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The exceptions are studies that have taken inspiration from nature to produce biomimetic surfaces that reasonably mimic the surface characteristics of such natural systems [ 6 – 10 ]. This has been achieved by incorporating beneficial topological characteristics of biological systems such as surface roughness and wettability encompassing dispersive interactions and transient hydrogen bonding between such surfaces/entities and the microorganism to thwart its adhesion [ 16 – 18 ]. Importantly, all such strategies have been mainly driven by the sole desire to prevent adhesion of viruses and bacteria in the first place.…”

Section: Perspectivementioning

confidence: 99%

Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective

2021

View full text Add to dashboard Cite

Graphic abstract Coronaviruses COVID-19, SARS-CoV and NL63 use spikes in their corona to bind to angiotensin converting enzyme 2 (ACE2) sites on cytoskeletal membranes of host cells to deliver their viral payload. While groups such as disulfides in ACE2’s zinc metallopeptidase, and also in COVID-19’s spikes, facilitate such binding, it is worth exploring how similar complementary sites on materials such as polymers, metals, ceramics, fabrics, and biomaterials promote binding of viruses and bacteria and how they could be further engineered to prevent bioactivity, or to act as agents to collect viral payloads in filters or similar devices. In that vein, this article offers a perspective on novel tools and approaches for chemically and topologically modifying most utilitarian surfaces via defensive topological vibrational engineering to either prevent such adhesion or to enhance adhesion and elicit vibrational characteristics/’musical signatures’ from the surfaces so that the structure of the binding sites of viruses and bacteria is permanently altered and/or their cellular machinery is permanently disabled by targeted chemical transformations. Supplementary Information The online version contains supplementary material available at 10.1557/s43580-021-00079-0.

show abstract

“…As the surface roughness reduces from the sub-micron scale to the nano-scale level, two phenomena occur -the surface state gradually changes from hydrophobic to hydrophilic and becomes increasingly unfavorable for the adhesion of most bacteria. Second, the anchoring points for bacterial adhesion gradually decrease, weakening the bacterial-surface bonding strength [77,78]. At the same time, the nanometric roughness ensures integrin activation leading to higher osteoblast attachment [79].…”

Section: Dimensional Analysis Of Ch/hamentioning

confidence: 99%

Nano-hydroxyapatite coating synthesized on quasi-fibrillar superstructures of collagen hydrolysate leads to superior osteoblast proliferation when compared to nano-hydroxyapatite synthesized on collagen fibrils

Banerjee

Bajaj

Bhat

et al. 2021

Preprint

View full text Add to dashboard Cite

This study had a two-fold objective: To utilize collagen hydrolysate for synthesizing a nanoscale Hydroxyapatite (HA) coating that would act as a superior osteoblast adhesion/ proliferation agent compared to collagen-derived HA (C/HA) and to comprehend the significant role played by structural constraints on HA nucleation. Collagen was extracted from pacu skin with a high yield of 65.3% (w/w of tissue). It was digested by collagenase and the hydrolysate (CH) was purified with a high yield of 0.68g/g of collagen. The CH peptides had a mass of 6kDa, a predominant PP-II conformation and formed self-assembling hierarchical structures at physiological pH with an average dimension of 842nm. The HA synthesized on CH (CH/HA) displayed higher yield when compared to C/HA. Structural analysis of CH/HA revealed that the PP-II peptides coiled to form mimic-helical moieties with reduced intermolecular packing distance of 0.9nm. The mimic helices cross-linked to form a vast quasi-fibrillar network that was comparatively smaller than collagen fibrils but exhibited enhanced stability and greater dynamicity. CH/HA displayed intense calcium-carboxyl interactions, sharper diffraction planes, smaller size of 48.6nm and a Ca/P ratio closer to 1.69 when compared to C/HA along with displaying serrated edge blooming crystals. Because of the small size, the CH/HA nanocrystals displayed significantly better osteoblast adhesion than C/HA and reduced the doubling time of cells. Overall, the results indicated that CH based nanocomposites displayed suitable morphological characteristics and cellular response for potential application as implant and bone graft coating material.

show abstract

Effects of surface roughness and texture on the bacterial adhesion on the bearing surface of bio-ceramic joint implants: An in vitro study

Cited by 60 publications

References 51 publications

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Chitosan/gelatin‐based bioactive and antibacterial coatings deposited via electrophoretic deposition

Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective

Nano-hydroxyapatite coating synthesized on quasi-fibrillar superstructures of collagen hydrolysate leads to superior osteoblast proliferation when compared to nano-hydroxyapatite synthesized on collagen fibrils

Contact Info

Product

Resources

About