20CrMnTiH is widely used as gear steel because of its good hardenability. Based on the Taguchi technique, an L9 orthogonal array was arranged, and the three main process parameters were deformation temperature, strain rate and strain, and their levels were in the range of 850oC~1050oC, 0.1 s-1~10s-1 and 0.2~0.8 respectively. Nine hot compression tests were carried out on a GLEEBLE 1500 simulator, and the stress-strain curves and microstructures were investigated. The experimental results showed that deformation temperature was the most significant parameter of flow stress maximum followed by strain rate and strain, and the impact significant degree of on the grain size after compression was shown in the following: deformation temperature > strain > strain rate.